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- W2730196670 abstract "Background Arrhythmia is a potentially fatal side effect of antipsychotics. A biologic predictive tool to prevent it is missing. Aim Identification of a genetic profile at risk for antipsychotic induced arrhythmia. Objective Identifying a molecular pathway enriched for antipsychotic induced QT-modifications. Methods Seven hundred and sixty-five SKZ individuals, M = 556, age = 40.93 ± 11.03 were included. QT-variation was a phase-specific created variable. A nested mixed regression served in R for clinical and molecular pathway analyses. Plink served for genetic analyses. Quality checking was standard, inflation factor was controlled by lambda values. Results Quetiapine and Perphenazine were associated with QT variation ( P = 0.002; Estimate = 5.79 and P = 5.67e-06; Estimate = 8.96 respectively). No other significant association was detected. No inflation was detected. Axon guidance and Collagen biosynthesis (Table 1) were associated with QT variation at a conservative (adjusted) P value < 0.01. Conclusions Two molecular pathways were identified as possibly involved in QT modifications during antispsychotic treatment in SKZ patients. Previous evidence supports a role of the same pathways in cardiac disorders [1,2]. Interaction of specific SNPs with the drugs will be focus of further research. Disclosure of interest The authors have not supplied their declaration of competing interest." @default.
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- W2730196670 date "2017-04-01" @default.
- W2730196670 modified "2023-09-26" @default.
- W2730196670 title "A molecular Pathway Analysis Informs the Genetic Risk for Arrhythmia During Antipsychotic Treatment" @default.
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- W2730196670 doi "https://doi.org/10.1016/j.eurpsy.2017.01.2045" @default.
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