FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2730604407> ?p ?o ?g. }

• W2730604407 abstract "We previously showed that Th1/type 1 inflammation marked by increased IFN-γ levels in the airways can be appreciated in 50% of patients with severe asthma, despite high dose corticosteroid (CS) treatment. We hypothesized that a downstream target of IFN-γ, CXCL10, which recruits Th1 cells via the cognate receptor CXCR3, is an important contributor to Th1high asthma and CS unresponsiveness. We show high levels of CXCL10 mRNA closely associated with IFNG levels in the BAL cells of 50% of severe asthmatics and also in the airways of mice subjected to a severe asthma model, both in the context of high-dose CS treatment. The inability of CS to dampen IFNG or CXCL10 expression was not because of impaired nuclear translocation of the glucocorticoid receptor (GR) or its transactivational functions. Rather, in the presence of CS and IFN-γ, STAT1 and GR were recruited on critical regulatory elements in the endogenous CXCL10 promoter in monocytes, albeit without any abatement of CXCL10 gene expression. High CXCL10 gene expression was also associated with a mast cell signature in both humans and mice, CXCR3 being also expressed by mast cells. These findings suggest that the IFN-γ-CXCL10 axis plays a central role in persistent type 1 inflammation that may be facilitated by CS therapy through GR-STAT1 cooperation converging on the CXCL10 promoter." @default.
• W2730604407 created "2017-07-14" @default.
• W2730604407 creator A5003495603 @default.
• W2730604407 creator A5010479652 @default.
• W2730604407 creator A5040784287 @default.
• W2730604407 creator A5043623665 @default.
• W2730604407 creator A5050793109 @default.
• W2730604407 creator A5060782005 @default.
• W2730604407 creator A5064565139 @default.
• W2730604407 creator A5065882228 @default.
• W2730604407 creator A5072110251 @default.
• W2730604407 creator A5073776956 @default.
• W2730604407 creator A5078918979 @default.
• W2730604407 creator A5080946365 @default.
• W2730604407 date "2017-07-06" @default.
• W2730604407 modified "2023-10-11" @default.
• W2730604407 title "Severe asthma in humans and mouse model suggests a CXCL10 signature underlies corticosteroid-resistant Th1 bias" @default.
• W2730604407 cites W1501690710 @default.
• W2730604407 cites W1665914593 @default.
• W2730604407 cites W1828087703 @default.
• W2730604407 cites W1860277694 @default.
• W2730604407 cites W1912933271 @default.
• W2730604407 cites W1940020093 @default.
• W2730604407 cites W1966747379 @default.
• W2730604407 cites W1972044159 @default.
• W2730604407 cites W1985264526 @default.
• W2730604407 cites W1985917583 @default.
• W2730604407 cites W2006821600 @default.
• W2730604407 cites W2009780198 @default.
• W2730604407 cites W2011126155 @default.
• W2730604407 cites W2012016864 @default.
• W2730604407 cites W2013105339 @default.
• W2730604407 cites W2016030444 @default.
• W2730604407 cites W2021701428 @default.
• W2730604407 cites W2023091898 @default.
• W2730604407 cites W2027400620 @default.
• W2730604407 cites W2031794136 @default.
• W2730604407 cites W2034947880 @default.
• W2730604407 cites W2042383304 @default.
• W2730604407 cites W2048053168 @default.
• W2730604407 cites W2049671131 @default.
• W2730604407 cites W2056337947 @default.
• W2730604407 cites W2059121736 @default.
• W2730604407 cites W2060037483 @default.
• W2730604407 cites W2070201691 @default.
• W2730604407 cites W2072931419 @default.
• W2730604407 cites W2074583717 @default.
• W2730604407 cites W2094736478 @default.
• W2730604407 cites W2094829202 @default.
• W2730604407 cites W2097204157 @default.
• W2730604407 cites W2098276532 @default.
• W2730604407 cites W2099029060 @default.
• W2730604407 cites W2115848892 @default.
• W2730604407 cites W2116865760 @default.
• W2730604407 cites W2122010894 @default.
• W2730604407 cites W2123197974 @default.
• W2730604407 cites W2132031140 @default.
• W2730604407 cites W2133162613 @default.
• W2730604407 cites W2149415013 @default.
• W2730604407 cites W2151137229 @default.
• W2730604407 cites W2153010224 @default.
• W2730604407 cites W2158121179 @default.
• W2730604407 cites W2160129587 @default.
• W2730604407 cites W2162886201 @default.
• W2730604407 cites W2166067782 @default.
• W2730604407 cites W2167421162 @default.
• W2730604407 cites W2170948066 @default.
• W2730604407 cites W2171522479 @default.
• W2730604407 cites W2405718054 @default.
• W2730604407 cites W2468702571 @default.
• W2730604407 cites W2486242608 @default.
• W2730604407 cites W2531496079 @default.
• W2730604407 cites W2580916015 @default.
• W2730604407 cites W2615078498 @default.
• W2730604407 cites W2616677193 @default.
• W2730604407 doi "https://doi.org/10.1172/jci.insight.94580" @default.
• W2730604407 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5499373" @default.
• W2730604407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28679952" @default.
• W2730604407 hasPublicationYear "2017" @default.
• W2730604407 type Work @default.
• W2730604407 sameAs 2730604407 @default.
• W2730604407 citedByCount "79" @default.
• W2730604407 countsByYear W27306044072018 @default.
• W2730604407 countsByYear W27306044072019 @default.
• W2730604407 countsByYear W27306044072020 @default.
• W2730604407 countsByYear W27306044072021 @default.
• W2730604407 countsByYear W27306044072022 @default.
• W2730604407 countsByYear W27306044072023 @default.
• W2730604407 crossrefType "journal-article" @default.
• W2730604407 hasAuthorship W2730604407A5003495603 @default.
• W2730604407 hasAuthorship W2730604407A5010479652 @default.
• W2730604407 hasAuthorship W2730604407A5040784287 @default.
• W2730604407 hasAuthorship W2730604407A5043623665 @default.
• W2730604407 hasAuthorship W2730604407A5050793109 @default.
• W2730604407 hasAuthorship W2730604407A5060782005 @default.
• W2730604407 hasAuthorship W2730604407A5064565139 @default.
• W2730604407 hasAuthorship W2730604407A5065882228 @default.
• W2730604407 hasAuthorship W2730604407A5072110251 @default.
• W2730604407 hasAuthorship W2730604407A5073776956 @default.
• W2730604407 hasAuthorship W2730604407A5078918979 @default.

• next