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- W2730787008 abstract "Abstract The work deals with the problems of pharmacokinetical modelling and the identification of the corresponding parameters on the analog-hybrid computer. The possibilities of progressive model extension with respect to the results of identification are also discussed. Sucaessfulness of the model response fitting to the curve generated from the data in vivo on the analog-hybrid computer is shown by the comparison with two identification methods using digital simulation. The results of urinary antiseptic pharmacokinetics point out the advantages of analog simulation and identification for the treatment of the pharmacokinetical problems. The model that is verified to be good by the identification can be used for the simulation of multiple dosing. So the quantity and frequency of dosing can be easily determined in such a way that the quantity of drug in the urine remains approximately constant within therapeutical limits. This is the most important condition for successful medical treatment." @default.
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- W2730787008 date "1978-01-01" @default.
- W2730787008 modified "2023-10-13" @default.
- W2730787008 title "Pharmacokinetical Models Development and Identification" @default.
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- W2730787008 doi "https://doi.org/10.1016/s1474-6670(17)65989-5" @default.
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