Matches in SemOpenAlex for { <https://semopenalex.org/work/W27308961> ?p ?o ?g. }
- W27308961 endingPage "245" @default.
- W27308961 startingPage "219" @default.
- W27308961 abstract "Previous studies have shown that imaging with positron emission tomography (PET) and single photon emission computed tomography (SPECT) radiotracers that are specific for brain dopamine receptors can be used to indirectly image the change in the levels of neurotransmitters within the brain. Most of the studies in addiction have focused on dopamine, since the dopamine neurons that project to the striatum have been shown to play a critical role in mediating addictive behavior. These imaging studies have shown that increased extracellular dopamine produced by psychostimulants can be measured with PET and SPECT. However, there are some technical issues associated with imaging changes in dopamine, and these are reviewed in this chapter. Among these are the loss of sensitivity, the time course of dopamine pulse relative to PET and SPECT imaging, and the question of affinity state of the receptor. In addition, animal studies have shown that most drugs of abuse increase extracellular dopamine in the striatum, yet not all produce a change in neurotransmitter that can be measured. As a result, imaging with a psychostimulant has become the preferred method for imaging presynaptic dopamine transmission, and this method has been used in studies of addiction. The results of these studies suggest that cocaine and alcohol addiction are associated with a loss of dopamine transmission, and a number of studies show that this loss correlates with severity of disease." @default.
- W27308961 created "2016-06-24" @default.
- W27308961 creator A5007496748 @default.
- W27308961 creator A5051088885 @default.
- W27308961 date "2009-09-15" @default.
- W27308961 modified "2023-09-27" @default.
- W27308961 title "Imaging Neurotransmitter Release by Drugs of Abuse" @default.
- W27308961 cites W1502799818 @default.
- W27308961 cites W1506870724 @default.
- W27308961 cites W1567767515 @default.
- W27308961 cites W1580993439 @default.
- W27308961 cites W1597083833 @default.
- W27308961 cites W1963530831 @default.
- W27308961 cites W1964300194 @default.
- W27308961 cites W1964795016 @default.
- W27308961 cites W1965679449 @default.
- W27308961 cites W1967784117 @default.
- W27308961 cites W1967966887 @default.
- W27308961 cites W1968332855 @default.
- W27308961 cites W1969866636 @default.
- W27308961 cites W1971840690 @default.
- W27308961 cites W1972248539 @default.
- W27308961 cites W1972559070 @default.
- W27308961 cites W1974037468 @default.
- W27308961 cites W1975607653 @default.
- W27308961 cites W1978301891 @default.
- W27308961 cites W1979603435 @default.
- W27308961 cites W1980446583 @default.
- W27308961 cites W1981327315 @default.
- W27308961 cites W1988659186 @default.
- W27308961 cites W1988922574 @default.
- W27308961 cites W1992381398 @default.
- W27308961 cites W1993691356 @default.
- W27308961 cites W1997463586 @default.
- W27308961 cites W1997829966 @default.
- W27308961 cites W1998454579 @default.
- W27308961 cites W1999948756 @default.
- W27308961 cites W2001062600 @default.
- W27308961 cites W2001360314 @default.
- W27308961 cites W2004205066 @default.
- W27308961 cites W2005509461 @default.
- W27308961 cites W2006411423 @default.
- W27308961 cites W2006715508 @default.
- W27308961 cites W2014061405 @default.
- W27308961 cites W2014469558 @default.
- W27308961 cites W2015046028 @default.
- W27308961 cites W2015500190 @default.
- W27308961 cites W2016678309 @default.
- W27308961 cites W2017163286 @default.
- W27308961 cites W2017659544 @default.
- W27308961 cites W2024141250 @default.
- W27308961 cites W2024249150 @default.
- W27308961 cites W2025782867 @default.
- W27308961 cites W2028039657 @default.
- W27308961 cites W2028322865 @default.
- W27308961 cites W2030939829 @default.
- W27308961 cites W2032471499 @default.
- W27308961 cites W2033624128 @default.
- W27308961 cites W2035628396 @default.
- W27308961 cites W2038246573 @default.
- W27308961 cites W2039634418 @default.
- W27308961 cites W2040903782 @default.
- W27308961 cites W2044600697 @default.
- W27308961 cites W2045572233 @default.
- W27308961 cites W2047727407 @default.
- W27308961 cites W2048458184 @default.
- W27308961 cites W2049064370 @default.
- W27308961 cites W2053445747 @default.
- W27308961 cites W2054230322 @default.
- W27308961 cites W2054388727 @default.
- W27308961 cites W2055087364 @default.
- W27308961 cites W2056376617 @default.
- W27308961 cites W2057379664 @default.
- W27308961 cites W2058103878 @default.
- W27308961 cites W2060645442 @default.
- W27308961 cites W2061992054 @default.
- W27308961 cites W2062008830 @default.
- W27308961 cites W2062446797 @default.
- W27308961 cites W2064671909 @default.
- W27308961 cites W2068055029 @default.
- W27308961 cites W2070096231 @default.
- W27308961 cites W2074494634 @default.
- W27308961 cites W2077707065 @default.
- W27308961 cites W2078633164 @default.
- W27308961 cites W2079598508 @default.
- W27308961 cites W2085754464 @default.
- W27308961 cites W2086392637 @default.
- W27308961 cites W2086517298 @default.
- W27308961 cites W2087708550 @default.
- W27308961 cites W2088522292 @default.
- W27308961 cites W2089223079 @default.
- W27308961 cites W2090481799 @default.
- W27308961 cites W2091591670 @default.
- W27308961 cites W2092106228 @default.
- W27308961 cites W2092673981 @default.
- W27308961 cites W2092802479 @default.
- W27308961 cites W2092820864 @default.
- W27308961 cites W2094579484 @default.