FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2731081970> ?p ?o ?g. }

• W2731081970 endingPage "62110" @default.
• W2731081970 startingPage "62099" @default.
• W2731081970 abstract "// Dao-Jun Chen 1, 2 , Lan-Ju Li 1, 2 , Xiao-Ke Yang 1, 2 , Tao Yu 1, 2 , Rui-Xue Leng 1, 2 , Hai-Feng Pan 1, 2 and Dong-Qing Ye 1, 2 1 Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China 2 Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui, China Correspondence to: Dong-Qing Ye, email: ydqahmu@gmail.com , ydq@ahmu.edu.cn Keywords: microRNA, vitamin D, SLE, T cells Received: August 15, 2016     Accepted: May 31, 2017     Published: July 07, 2017 ABSTRACT Vitamin D has been recognized as a potent immunomodulator and its deficiency is common in different population groups including patients with SLE. As miRNAs regulation plays a significant role in SLE, the present study aimed to evaluate the association between vitamin D status and miRNAs levels in patients with SLE. The serum concentrations of vitamin D (25-hydroxyvitamin D) and the levels of six miRNAs in T cells from patients with SLE were measured in 42 SLE cases and 48 healthy controls. Vitamin D treatment was also performed in isolated and cultured T cells from SLE patients in different times and doses. Vitamin D insufficiency (25-hydroxyvitamin D concentration<20 ng/ml) was more common in cases than in controls. Although age and BMI were similar, cases had significantly lower concentrations of miRNA-377, miRNA-342, miRNA-10a, miRNA-374b, miRNA-125a, and miRNA-410 than controls. Furthermore, a significant positive correlation was also observed between 25-hydroxyvitamin D concentrations and measured miRNAs levels. A significant difference in observed miRNAs levels was also observed in patients with 25-hydroxyvitamin D insufficiency compared with patients with 25-hydroxyvitamin D concentration≥20 ng/ml. And 1α,25(OH) 2 D 3 differentially regulated miRNAs expression in dose- and time- manner in vitro . Lower expressions of miRNA-377, miRNA-342, miRNA-10a, miRNA-374b, miRNA-125a, and miRNA-410 were found in SLE patients. And severe vitamin D deficiency is associated with decreased observed miRNAs levels in SLE patients. A 25-hydroxyvitamin D concentration value<20 ng/ml is suggested as the “cut-off” for such immunological alterations in patients with SLE." @default.
• W2731081970 created "2017-07-14" @default.
• W2731081970 creator A5050353133 @default.
• W2731081970 creator A5051283655 @default.
• W2731081970 creator A5057503770 @default.
• W2731081970 creator A5072108606 @default.
• W2731081970 creator A5082557728 @default.
• W2731081970 creator A5088368600 @default.
• W2731081970 date "2017-07-07" @default.
• W2731081970 modified "2023-10-17" @default.
• W2731081970 title "Altered microRNAs expression in T cells of patients with SLE involved in the lack of vitamin D" @default.
• W2731081970 cites W126386951 @default.
• W2731081970 cites W1602704667 @default.
• W2731081970 cites W1626755795 @default.
• W2731081970 cites W1689052539 @default.
• W2731081970 cites W1822689666 @default.
• W2731081970 cites W1852629292 @default.
• W2731081970 cites W1873346575 @default.
• W2731081970 cites W1985613212 @default.
• W2731081970 cites W1988740302 @default.
• W2731081970 cites W1992348279 @default.
• W2731081970 cites W1995592610 @default.
• W2731081970 cites W2028950751 @default.
• W2731081970 cites W2032427871 @default.
• W2731081970 cites W2047648173 @default.
• W2731081970 cites W2048952687 @default.
• W2731081970 cites W2049306810 @default.
• W2731081970 cites W2051697614 @default.
• W2731081970 cites W2075133329 @default.
• W2731081970 cites W2076980250 @default.
• W2731081970 cites W2078357230 @default.
• W2731081970 cites W2082904905 @default.
• W2731081970 cites W2092487710 @default.
• W2731081970 cites W2101231466 @default.
• W2731081970 cites W2101352773 @default.
• W2731081970 cites W2112398552 @default.
• W2731081970 cites W2114690058 @default.
• W2731081970 cites W2119820982 @default.
• W2731081970 cites W2133616902 @default.
• W2731081970 cites W2135604027 @default.
• W2731081970 cites W2227316047 @default.
• W2731081970 cites W2228163558 @default.
• W2731081970 cites W2238943778 @default.
• W2731081970 cites W2250245177 @default.
• W2731081970 cites W2253972201 @default.
• W2731081970 cites W2283001164 @default.
• W2731081970 cites W2287188530 @default.
• W2731081970 cites W2290674316 @default.
• W2731081970 cites W2290800552 @default.
• W2731081970 cites W2292620083 @default.
• W2731081970 cites W2302024964 @default.
• W2731081970 cites W2319417455 @default.
• W2731081970 cites W2969023506 @default.
• W2731081970 cites W3025075911 @default.
• W2731081970 cites W2155788927 @default.
• W2731081970 doi "https://doi.org/10.18632/oncotarget.19062" @default.
• W2731081970 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5617489" @default.
• W2731081970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28977929" @default.
• W2731081970 hasPublicationYear "2017" @default.
• W2731081970 type Work @default.
• W2731081970 sameAs 2731081970 @default.
• W2731081970 citedByCount "11" @default.
• W2731081970 countsByYear W27310819702018 @default.
• W2731081970 countsByYear W27310819702019 @default.
• W2731081970 countsByYear W27310819702020 @default.
• W2731081970 countsByYear W27310819702021 @default.
• W2731081970 crossrefType "journal-article" @default.
• W2731081970 hasAuthorship W2731081970A5050353133 @default.
• W2731081970 hasAuthorship W2731081970A5051283655 @default.
• W2731081970 hasAuthorship W2731081970A5057503770 @default.
• W2731081970 hasAuthorship W2731081970A5072108606 @default.
• W2731081970 hasAuthorship W2731081970A5082557728 @default.
• W2731081970 hasAuthorship W2731081970A5088368600 @default.
• W2731081970 hasBestOaLocation W27310819701 @default.
• W2731081970 hasConcept C104317684 @default.
• W2731081970 hasConcept C107130276 @default.
• W2731081970 hasConcept C124490489 @default.
• W2731081970 hasConcept C126322002 @default.
• W2731081970 hasConcept C140556311 @default.
• W2731081970 hasConcept C145059251 @default.
• W2731081970 hasConcept C203014093 @default.
• W2731081970 hasConcept C2779740938 @default.
• W2731081970 hasConcept C2908647359 @default.
• W2731081970 hasConcept C42407357 @default.
• W2731081970 hasConcept C54355233 @default.
• W2731081970 hasConcept C71924100 @default.
• W2731081970 hasConcept C86803240 @default.
• W2731081970 hasConcept C90924648 @default.
• W2731081970 hasConcept C99454951 @default.
• W2731081970 hasConceptScore W2731081970C104317684 @default.
• W2731081970 hasConceptScore W2731081970C107130276 @default.
• W2731081970 hasConceptScore W2731081970C124490489 @default.
• W2731081970 hasConceptScore W2731081970C126322002 @default.
• W2731081970 hasConceptScore W2731081970C140556311 @default.
• W2731081970 hasConceptScore W2731081970C145059251 @default.
• W2731081970 hasConceptScore W2731081970C203014093 @default.
• W2731081970 hasConceptScore W2731081970C2779740938 @default.
• W2731081970 hasConceptScore W2731081970C2908647359 @default.

• next