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• W2731182552 abstract "Abstract Background Several recent studies suggested that nonsteroidal anti‐inflammation drugs ( NSAID s) could prevent the pancreatitis after endoscopic retrograde cholangiopancreatography ( ERCP ). However, the routes of administration, the dosages of NSAID s and the potential efficacy in reducing the severity of pancreatitis remain controversial. The aim of this meta‐analysis was to evaluate the efficacy of NSAID s for post‐ ERCP pancreatitis ( PEP ) prophylaxis. Methods We systematically searched PubMed, Embase, EBSCO , Elsevier and Web of Science databases up to 1 October 2016 for relevant studies. Results A total of 24 studies met the inclusion criteria. Compared to the controls, the risk of pancreatitis was much lower in the NSAID s group ( OR = 0.57, 95% CI : 0.48–0.67, P < 0.0001). However, NSAID s were not effective in reducing the risk of moderate to severe pancreatitis compared with placebo ( OR = 0.75, 95% CI : 0.57–1.00). In the subanalyses, rectal administration was the only effective route ( OR = 0.51, 95% CI : 0.42–0.62), and the risk of PEP was reduced in both randomized controlled trials ( RCT s) ( OR = 0.63, 95% CI : 0.52–0.76) and case–control articles (C–Cs) ( OR = 0.40, 95% CI : 0.28–0.58). Conclusions Prophylactic administration of NSAID s reduced the incidence of PEP in both RCT s and C–Cs, especially when rectally administered, but was not effective in reducing the risk of moderate to severe pancreatitis." @default.
• W2731182552 created "2017-07-14" @default.
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• W2731182552 date "2017-08-16" @default.
• W2731182552 modified "2023-10-14" @default.
• W2731182552 title "Nonsteroidal anti-inflammatory drugs reduce the incidence of post-endoscopic retrograde cholangiopancreatography pancreatitis: a meta-analysis" @default.
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• W2731182552 doi "https://doi.org/10.1002/jhbp.489" @default.
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