FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2731389892> ?p ?o ?g. }

• W2731389892 endingPage "1029" @default.
• W2731389892 startingPage "1020" @default.
• W2731389892 abstract "Statins are the most commonly prescribed agents used to modulate cholesterol levels in course of hypercholesterolemia treatment because of their relative tolerability and LDL-C lowering effect. Recently, there are emerging interests in the perspectives of statin drugs as anticancer agents based on preclinical evidence of their antiproliferative, proapoptotic, and anti-invasive properties. Functional impact of statin application on transformed cells still remains obscure that requires systematic study on adequate cellular models to provide correct comparison with their non-transformed counterparts. Cholesterol is the major lipid component of mammalian cells and it plays a crucial role in organization, lateral heterogeneity, and dynamics of plasma membrane as well as in membrane-cytoskeleton interrelations. To date, it is uncertain whether cellular effects of statins involve lipid-dependent alteration of plasma membrane. Here, the effects of simvastatin on lipid rafts, F-actin network and cellular viability were determined in comparative experiments on transformed fibroblasts and their non-transformed counterpart. GM1 lipid raft marker staining indicated no change of lipid raft integrity after short- or long-term simvastatin treatments. In the same time, simvastatin induced cytoskeleton rearrangement including partial F-actin disruption in cholesterol- and lipid raft-independent manner. Simvastatin dose-dependently affected viability of BALB/3T3 and 3T3B-SV40 cell lines: transformed fibroblasts were noticeably more sensitive to simvastatin comparing to non-transformed cells." @default.
• W2731389892 created "2017-07-14" @default.
• W2731389892 creator A5009804972 @default.
• W2731389892 creator A5034727759 @default.
• W2731389892 creator A5059835354 @default.
• W2731389892 date "2017-07-16" @default.
• W2731389892 modified "2023-09-26" @default.
• W2731389892 title "Simvastatin induced actin cytoskeleton disassembly in normal and transformed fibroblasts without affecting lipid raft integrity" @default.
• W2731389892 cites W1553087323 @default.
• W2731389892 cites W1603021076 @default.
• W2731389892 cites W1608849851 @default.
• W2731389892 cites W1735246829 @default.
• W2731389892 cites W1968747555 @default.
• W2731389892 cites W1986688031 @default.
• W2731389892 cites W1989310357 @default.
• W2731389892 cites W1990676663 @default.
• W2731389892 cites W1991105915 @default.
• W2731389892 cites W1995435834 @default.
• W2731389892 cites W2009953511 @default.
• W2731389892 cites W2029850357 @default.
• W2731389892 cites W2040565528 @default.
• W2731389892 cites W2046440427 @default.
• W2731389892 cites W2052334592 @default.
• W2731389892 cites W2053134310 @default.
• W2731389892 cites W2056247789 @default.
• W2731389892 cites W2057883674 @default.
• W2731389892 cites W2061383773 @default.
• W2731389892 cites W2068211237 @default.
• W2731389892 cites W2070487296 @default.
• W2731389892 cites W2071124826 @default.
• W2731389892 cites W2094264753 @default.
• W2731389892 cites W2111778006 @default.
• W2731389892 cites W2126909855 @default.
• W2731389892 cites W2136558879 @default.
• W2731389892 cites W2144124482 @default.
• W2731389892 cites W2144185116 @default.
• W2731389892 cites W2146546690 @default.
• W2731389892 cites W2153693804 @default.
• W2731389892 cites W2159974155 @default.
• W2731389892 cites W2160085864 @default.
• W2731389892 cites W2182918784 @default.
• W2731389892 cites W2413174565 @default.
• W2731389892 cites W47204531 @default.
• W2731389892 doi "https://doi.org/10.1002/cbin.10812" @default.
• W2731389892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28656734" @default.
• W2731389892 hasPublicationYear "2017" @default.
• W2731389892 type Work @default.
• W2731389892 sameAs 2731389892 @default.
• W2731389892 citedByCount "7" @default.
• W2731389892 countsByYear W27313898922018 @default.
• W2731389892 countsByYear W27313898922020 @default.
• W2731389892 countsByYear W27313898922021 @default.
• W2731389892 countsByYear W27313898922022 @default.
• W2731389892 countsByYear W27313898922023 @default.
• W2731389892 crossrefType "journal-article" @default.
• W2731389892 hasAuthorship W2731389892A5009804972 @default.
• W2731389892 hasAuthorship W2731389892A5034727759 @default.
• W2731389892 hasAuthorship W2731389892A5059835354 @default.
• W2731389892 hasConcept C142669718 @default.
• W2731389892 hasConcept C1491633281 @default.
• W2731389892 hasConcept C185592680 @default.
• W2731389892 hasConcept C2776329913 @default.
• W2731389892 hasConcept C2776839432 @default.
• W2731389892 hasConcept C2993400109 @default.
• W2731389892 hasConcept C53227056 @default.
• W2731389892 hasConcept C55493867 @default.
• W2731389892 hasConcept C62478195 @default.
• W2731389892 hasConcept C79266657 @default.
• W2731389892 hasConcept C86803240 @default.
• W2731389892 hasConcept C95444343 @default.
• W2731389892 hasConcept C98274493 @default.
• W2731389892 hasConceptScore W2731389892C142669718 @default.
• W2731389892 hasConceptScore W2731389892C1491633281 @default.
• W2731389892 hasConceptScore W2731389892C185592680 @default.
• W2731389892 hasConceptScore W2731389892C2776329913 @default.
• W2731389892 hasConceptScore W2731389892C2776839432 @default.
• W2731389892 hasConceptScore W2731389892C2993400109 @default.
• W2731389892 hasConceptScore W2731389892C53227056 @default.
• W2731389892 hasConceptScore W2731389892C55493867 @default.
• W2731389892 hasConceptScore W2731389892C62478195 @default.
• W2731389892 hasConceptScore W2731389892C79266657 @default.
• W2731389892 hasConceptScore W2731389892C86803240 @default.
• W2731389892 hasConceptScore W2731389892C95444343 @default.
• W2731389892 hasConceptScore W2731389892C98274493 @default.
• W2731389892 hasFunder F4320321079 @default.
• W2731389892 hasFunder F4320324099 @default.
• W2731389892 hasIssue "9" @default.
• W2731389892 hasLocation W27313898921 @default.
• W2731389892 hasLocation W27313898922 @default.
• W2731389892 hasOpenAccess W2731389892 @default.
• W2731389892 hasPrimaryLocation W27313898921 @default.
• W2731389892 hasRelatedWork W2011145599 @default.
• W2731389892 hasRelatedWork W2011790546 @default.
• W2731389892 hasRelatedWork W2122625756 @default.
• W2731389892 hasRelatedWork W2132817489 @default.
• W2731389892 hasRelatedWork W2169220518 @default.
• W2731389892 hasRelatedWork W2332601173 @default.
• W2731389892 hasRelatedWork W2342812531 @default.

• next