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- W273144445 abstract "In extensive research on rodents and in preliminary studies on nonhuman primates, allogeneic embryonic ventral mesencephalic grafts are superior to allogeneic adult adrenal medullary grafts in respect to intrastriatal graft survival and functional effectiveness in animal models of Parkinson syndrome. Intrastriatal grafting of Parkinson patients with their own adrenal medulla has so far given discrepant results. The adrenal medulla itself appears to be affected by Parkinson’s disease. Transplantation of embryonic ventral mesencephalic tissue raises ethical concern. Issues such as method of application, target areas and long term immunological graft-host reaction await further research in non-human primates. In the future, catecholamine-synthesizing cell lines may provide a valid alternative to presently considered donor tissue." @default.
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- W273144445 date "1989-01-01" @default.
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- W273144445 title "Transplantation of dopamine-synthesizing cells—new therapy for Parkinson’s disease?" @default.
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