Matches in SemOpenAlex for { <https://semopenalex.org/work/W2731601076> ?p ?o ?g. }
- W2731601076 endingPage "95" @default.
- W2731601076 startingPage "91" @default.
- W2731601076 abstract "Abstract As the disease-free 5-year-survival of late stage laryngeal carcinoma patients is extremely low, indoleamine-2,3-dioxygenase-1 (IDO)-induced tryptophan degradation may represent an immune escape mechanism which plays an important role in cancer spreading in advanced stage laryngeal cancers. We examined whether the late stage laryngeal cancer enhances tumor immune evasion by the expression of systemic IDO activities and chronic cellular immune activation. Twenty-two of 42 male laryngeal cancer patients were classified as late stage cancer according to American Joint Committee on Cancer (AJCC) criteria. Their serum neopterin, tryptophan and kynurenine concentrations were compared with 30 cancer-free individuals. IDO activity was approved by correlation between serum neopterin and kynurenine/tryptophan. Late stage cancer patients preoperatively showed a significantly higher IDO activity compared to controls and early stage cancer cases. Six months after tumor removal, late stage cancer patients although having higher serum neopterin concentration compared to early stage patients or controls, they showed a significant decrease in IDO activity and tryptophan consumption. Increased systemic IDO activity may provoke the escape of tumor cells from the immune surveillance of the host. High IDO activity is due to the presence of tumor mass. Persistence of high serum neopterin levels despite tumor removal may indicate poor prognosis." @default.
- W2731601076 created "2017-07-14" @default.
- W2731601076 creator A5026671889 @default.
- W2731601076 creator A5058488862 @default.
- W2731601076 creator A5069922018 @default.
- W2731601076 creator A5081156604 @default.
- W2731601076 creator A5087138354 @default.
- W2731601076 date "2017-06-30" @default.
- W2731601076 modified "2023-10-18" @default.
- W2731601076 title "Serum neopterin concentrations and tryptophan degradation pattern in patients with late stage larynx carcinoma" @default.
- W2731601076 cites W1481537584 @default.
- W2731601076 cites W1553983160 @default.
- W2731601076 cites W1603640418 @default.
- W2731601076 cites W1808357633 @default.
- W2731601076 cites W1925988920 @default.
- W2731601076 cites W1965661914 @default.
- W2731601076 cites W1973251492 @default.
- W2731601076 cites W1984116870 @default.
- W2731601076 cites W1987171603 @default.
- W2731601076 cites W2000336468 @default.
- W2731601076 cites W2014837971 @default.
- W2731601076 cites W2028575737 @default.
- W2731601076 cites W2046214100 @default.
- W2731601076 cites W2052787011 @default.
- W2731601076 cites W2053028063 @default.
- W2731601076 cites W2061087079 @default.
- W2731601076 cites W2061395079 @default.
- W2731601076 cites W2069766438 @default.
- W2731601076 cites W2072078248 @default.
- W2731601076 cites W2079515425 @default.
- W2731601076 cites W2090410108 @default.
- W2731601076 cites W2094370941 @default.
- W2731601076 cites W2097271095 @default.
- W2731601076 cites W2111698297 @default.
- W2731601076 cites W2115230511 @default.
- W2731601076 cites W2127339314 @default.
- W2731601076 cites W2127903252 @default.
- W2731601076 cites W2134151792 @default.
- W2731601076 cites W2318403316 @default.
- W2731601076 cites W2418695609 @default.
- W2731601076 cites W2604266972 @default.
- W2731601076 cites W4240640847 @default.
- W2731601076 cites W4256129954 @default.
- W2731601076 doi "https://doi.org/10.1515/pterid-2017-0004" @default.
- W2731601076 hasPublicationYear "2017" @default.
- W2731601076 type Work @default.
- W2731601076 sameAs 2731601076 @default.
- W2731601076 citedByCount "0" @default.
- W2731601076 crossrefType "journal-article" @default.
- W2731601076 hasAuthorship W2731601076A5026671889 @default.
- W2731601076 hasAuthorship W2731601076A5058488862 @default.
- W2731601076 hasAuthorship W2731601076A5069922018 @default.
- W2731601076 hasAuthorship W2731601076A5081156604 @default.
- W2731601076 hasAuthorship W2731601076A5087138354 @default.
- W2731601076 hasBestOaLocation W27316010761 @default.
- W2731601076 hasConcept C121608353 @default.
- W2731601076 hasConcept C126322002 @default.
- W2731601076 hasConcept C143998085 @default.
- W2731601076 hasConcept C146357865 @default.
- W2731601076 hasConcept C151730666 @default.
- W2731601076 hasConcept C203014093 @default.
- W2731601076 hasConcept C2776603314 @default.
- W2731601076 hasConcept C2776706248 @default.
- W2731601076 hasConcept C2777503454 @default.
- W2731601076 hasConcept C515207424 @default.
- W2731601076 hasConcept C55493867 @default.
- W2731601076 hasConcept C71924100 @default.
- W2731601076 hasConcept C83478079 @default.
- W2731601076 hasConcept C86803240 @default.
- W2731601076 hasConcept C8891405 @default.
- W2731601076 hasConcept C90924648 @default.
- W2731601076 hasConceptScore W2731601076C121608353 @default.
- W2731601076 hasConceptScore W2731601076C126322002 @default.
- W2731601076 hasConceptScore W2731601076C143998085 @default.
- W2731601076 hasConceptScore W2731601076C146357865 @default.
- W2731601076 hasConceptScore W2731601076C151730666 @default.
- W2731601076 hasConceptScore W2731601076C203014093 @default.
- W2731601076 hasConceptScore W2731601076C2776603314 @default.
- W2731601076 hasConceptScore W2731601076C2776706248 @default.
- W2731601076 hasConceptScore W2731601076C2777503454 @default.
- W2731601076 hasConceptScore W2731601076C515207424 @default.
- W2731601076 hasConceptScore W2731601076C55493867 @default.
- W2731601076 hasConceptScore W2731601076C71924100 @default.
- W2731601076 hasConceptScore W2731601076C83478079 @default.
- W2731601076 hasConceptScore W2731601076C86803240 @default.
- W2731601076 hasConceptScore W2731601076C8891405 @default.
- W2731601076 hasConceptScore W2731601076C90924648 @default.
- W2731601076 hasIssue "2" @default.
- W2731601076 hasLocation W27316010761 @default.
- W2731601076 hasOpenAccess W2731601076 @default.
- W2731601076 hasPrimaryLocation W27316010761 @default.
- W2731601076 hasRelatedWork W1553983160 @default.
- W2731601076 hasRelatedWork W1557983778 @default.
- W2731601076 hasRelatedWork W1990075521 @default.
- W2731601076 hasRelatedWork W2024939871 @default.
- W2731601076 hasRelatedWork W2081756664 @default.
- W2731601076 hasRelatedWork W2084232983 @default.
- W2731601076 hasRelatedWork W2330844956 @default.