FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2731699938> ?p ?o ?g. }

• W2731699938 endingPage "252" @default.
• W2731699938 startingPage "241" @default.
• W2731699938 abstract "Phage therapy has been viewed as a potential treatment for bacterial infections for over a century. Yet, the year 2016 marks one of the first phase I/II human trials of a phage therapeutic - to treat burn wound patients in Europe. The slow progress in realizing clinical therapeutics is matched by a similar dearth in principled understanding of phage therapy. Theoretical models and in vitro experiments find that combining phage and bacteria often leads to coexistence of both phage and bacteria or phage elimination altogether. Both outcomes stand in contrast to the stated goals of phage therapy. A potential resolution to the gap between models, experiments, and therapeutic use of phage is the hypothesis that the combined effect of phage and host immune system can synergistically eliminate bacterial pathogens. Here, we propose a phage therapy model that considers the nonlinear dynamics arising from interactions between bacteria, phage and the host innate immune system. The model builds upon earlier efforts by incorporating a maximum capacity of the immune response and density-dependent immune evasion by bacteria. We analytically identify a synergistic regime in this model in which phage and the innate immune response jointly contribute to the elimination of the target bacteria. Crucially, we find that in this synergistic regime, neither phage alone nor the innate immune system alone can eliminate the bacteria. We confirm these findings using numerical simulations in biologically plausible scenarios. We utilize our numerical simulations to explore the synergistic effect and its significance for guiding the use of phage therapy in clinically relevant applications." @default.
• W2731699938 created "2017-07-14" @default.
• W2731699938 creator A5000231856 @default.
• W2731699938 creator A5020490780 @default.
• W2731699938 date "2017-09-01" @default.
• W2731699938 modified "2023-10-12" @default.
• W2731699938 title "Modeling the synergistic elimination of bacteria by phage and the innate immune system" @default.
• W2731699938 cites W112013909 @default.
• W2731699938 cites W1507791717 @default.
• W2731699938 cites W1799454977 @default.
• W2731699938 cites W1869714721 @default.
• W2731699938 cites W1902380478 @default.
• W2731699938 cites W1920153897 @default.
• W2731699938 cites W1973208496 @default.
• W2731699938 cites W1976646654 @default.
• W2731699938 cites W1978294333 @default.
• W2731699938 cites W1980715218 @default.
• W2731699938 cites W1982286661 @default.
• W2731699938 cites W1992551495 @default.
• W2731699938 cites W1995337037 @default.
• W2731699938 cites W1996465211 @default.
• W2731699938 cites W2012179517 @default.
• W2731699938 cites W2014362995 @default.
• W2731699938 cites W2014783118 @default.
• W2731699938 cites W2019196691 @default.
• W2731699938 cites W2019197162 @default.
• W2731699938 cites W2020162639 @default.
• W2731699938 cites W2021427972 @default.
• W2731699938 cites W2022658844 @default.
• W2731699938 cites W2024931582 @default.
• W2731699938 cites W2026473901 @default.
• W2731699938 cites W2036991016 @default.
• W2731699938 cites W2043036082 @default.
• W2731699938 cites W2045864306 @default.
• W2731699938 cites W2047983958 @default.
• W2731699938 cites W2050998488 @default.
• W2731699938 cites W2051196787 @default.
• W2731699938 cites W2057282918 @default.
• W2731699938 cites W2062948385 @default.
• W2731699938 cites W2068345774 @default.
• W2731699938 cites W2069811388 @default.
• W2731699938 cites W2070284460 @default.
• W2731699938 cites W2071605567 @default.
• W2731699938 cites W2075537997 @default.
• W2731699938 cites W2079032703 @default.
• W2731699938 cites W2080490082 @default.
• W2731699938 cites W2081199994 @default.
• W2731699938 cites W2082883430 @default.
• W2731699938 cites W2089700892 @default.
• W2731699938 cites W2090817404 @default.
• W2731699938 cites W2097842992 @default.
• W2731699938 cites W2098784648 @default.
• W2731699938 cites W2099670135 @default.
• W2731699938 cites W2104223843 @default.
• W2731699938 cites W2104324648 @default.
• W2731699938 cites W2113689947 @default.
• W2731699938 cites W2121911698 @default.
• W2731699938 cites W2135092459 @default.
• W2731699938 cites W2136294927 @default.
• W2731699938 cites W2137079217 @default.
• W2731699938 cites W2140843952 @default.
• W2731699938 cites W2140872784 @default.
• W2731699938 cites W2141865669 @default.
• W2731699938 cites W2143682782 @default.
• W2731699938 cites W2144440398 @default.
• W2731699938 cites W2153421727 @default.
• W2731699938 cites W2159445822 @default.
• W2731699938 cites W2159819650 @default.
• W2731699938 cites W2163435738 @default.
• W2731699938 cites W2166199652 @default.
• W2731699938 cites W2170035687 @default.
• W2731699938 cites W2316683916 @default.
• W2731699938 cites W2327147137 @default.
• W2731699938 cites W2397035397 @default.
• W2731699938 cites W2953078029 @default.
• W2731699938 doi "https://doi.org/10.1016/j.jtbi.2017.06.037" @default.
• W2731699938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28668337" @default.
• W2731699938 hasPublicationYear "2017" @default.
• W2731699938 type Work @default.
• W2731699938 sameAs 2731699938 @default.
• W2731699938 citedByCount "80" @default.
• W2731699938 countsByYear W27316999382017 @default.
• W2731699938 countsByYear W27316999382018 @default.
• W2731699938 countsByYear W27316999382019 @default.
• W2731699938 countsByYear W27316999382020 @default.
• W2731699938 countsByYear W27316999382021 @default.
• W2731699938 countsByYear W27316999382022 @default.
• W2731699938 countsByYear W27316999382023 @default.
• W2731699938 crossrefType "journal-article" @default.
• W2731699938 hasAuthorship W2731699938A5000231856 @default.
• W2731699938 hasAuthorship W2731699938A5020490780 @default.
• W2731699938 hasBestOaLocation W27316999381 @default.
• W2731699938 hasConcept C104317684 @default.
• W2731699938 hasConcept C136449434 @default.
• W2731699938 hasConcept C203014093 @default.
• W2731699938 hasConcept C2776441376 @default.
• W2731699938 hasConcept C2779256223 @default.
• W2731699938 hasConcept C523546767 @default.

• next