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- W2732017093 abstract "The Bruton tyrosine kinase (BTK) is a central hub in the B cell receptor (BCR) pathway and strongly influences B cell maturation, differentiation and proliferation. Not surprisingly, BTK plays an essential role in the pathogenesis of various B cell lymphomas. Inhibitors of BTK have broadened our therapeutic options in several B cell lymphomas and already are an integral element in the treatment of Mantle Cell Lymphoma (MCL), chronic lymphocytic leukemia (CLL) and Waldenström's marcoglobulinemia. Several second generation BTK inhibitors are in clinical development and might further improve tolerability and efficacy of therapy in advanced stage CLL and MCL. Areas covered: This review illustrates the mechanism of action of BTK inhibitors and provides a comprehensive summary of key clinical trials in the development of BTK inhibitors. Characteristics of second generation BTK-inhibitors are described. Expert opinion: With accumulation of clinical experience after drug approval, longer patient follow-up and larger numbers of treated patients, future development will focus on the identification of intelligent treatment combinations. Individual selection of patients with distinct biologically properties might guide treatment decisions. While BTK inhibitors are moving to earlier treatment lines, the incorporation of these drugs into a comprehensive therapeutic strategy is still difficult to date." @default.
- W2732017093 created "2017-07-14" @default.
- W2732017093 creator A5009055012 @default.
- W2732017093 creator A5046049357 @default.
- W2732017093 date "2017-07-10" @default.
- W2732017093 modified "2023-10-14" @default.
- W2732017093 title "Bruton’s tyrosine kinase inhibitors in B-cell lymphoma: current experience and future perspectives" @default.
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- W2732017093 doi "https://doi.org/10.1080/13543784.2017.1349097" @default.
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