Matches in SemOpenAlex for { <https://semopenalex.org/work/W2732140867> ?p ?o ?g. }
- W2732140867 abstract "Liver fibrosis is a complex inflammatory and fibrogenic process that results from chronic liver injury and represents an early step in the progression of cirrhosis. Several cell types [hepatic stellate cells (HSCs), hepatocytes, liver sinusoidal endothelial cells (LSECs), and Kupffer cells (KCs)], cytokines [platelet-derived growth factor (PDGF), transforming growth factor (TGF)-β, tumor necrosis factor (TNF)-α, interferons (IFNs), interleukins (ILs)], oxidative stress, and microRNAs (miRNAs) are involved in the initiation and progression of liver fibrosis/cirrhosis. Generally, liver fibrosis begins with the stimulation of inflammatory immune cells to secrete cytokines, growth factors, and other activator molecules. These chemical mediators direct HSCs to activate and synthesize large amounts of extracellular matrix (ECM) components. Therefore, HSC activation is a pivotal event in the development of fibrosis and a major contributor to collagen (specifically type I) accumulation. The inhibitory effect of halofuginone on collagen type α1(I) synthesis and ECM deposition has been shown in several experimental models of fibrotic diseases. Halofuginone inhibits TGF-β–induced phosphorylation of Smad3, which is a key phenomenon in the fibrogenesis. It also regulates cell growth and differentiation, apoptosis, cell migration, and immune cell function in liver fibrosis/cirrhosis. This review discusses the etiology and mechanisms of liver fibrosis/cirrhosis and the promising role of anti-fibrotic agent halofuginone." @default.
- W2732140867 created "2017-07-14" @default.
- W2732140867 creator A5090894601 @default.
- W2732140867 date "2017-07-05" @default.
- W2732140867 modified "2023-09-27" @default.
- W2732140867 title "The Promising Role of Anti-Fibrotic Agent Halofuginone in Liver Fibrosis/Cirrhosis" @default.
- W2732140867 cites W1528348540 @default.
- W2732140867 cites W1587181103 @default.
- W2732140867 cites W1593855885 @default.
- W2732140867 cites W1601292221 @default.
- W2732140867 cites W1760933578 @default.
- W2732140867 cites W1781806439 @default.
- W2732140867 cites W1865056759 @default.
- W2732140867 cites W1873311709 @default.
- W2732140867 cites W1882621091 @default.
- W2732140867 cites W1894213601 @default.
- W2732140867 cites W1963920328 @default.
- W2732140867 cites W1964359747 @default.
- W2732140867 cites W1968460020 @default.
- W2732140867 cites W1968798984 @default.
- W2732140867 cites W1970028988 @default.
- W2732140867 cites W1971670779 @default.
- W2732140867 cites W1973282828 @default.
- W2732140867 cites W1974144714 @default.
- W2732140867 cites W1975694876 @default.
- W2732140867 cites W1975752601 @default.
- W2732140867 cites W1978505738 @default.
- W2732140867 cites W1978711808 @default.
- W2732140867 cites W1980325398 @default.
- W2732140867 cites W1980699998 @default.
- W2732140867 cites W1982160368 @default.
- W2732140867 cites W1983251505 @default.
- W2732140867 cites W1983541098 @default.
- W2732140867 cites W1985403454 @default.
- W2732140867 cites W1985980869 @default.
- W2732140867 cites W1988613128 @default.
- W2732140867 cites W1989868286 @default.
- W2732140867 cites W1990206356 @default.
- W2732140867 cites W1992857831 @default.
- W2732140867 cites W1993518161 @default.
- W2732140867 cites W1995086133 @default.
- W2732140867 cites W1997592259 @default.
- W2732140867 cites W1998004099 @default.
- W2732140867 cites W1998931253 @default.
- W2732140867 cites W1999374933 @default.
- W2732140867 cites W2000463136 @default.
- W2732140867 cites W2000581973 @default.
- W2732140867 cites W2001077476 @default.
- W2732140867 cites W2001164361 @default.
- W2732140867 cites W2003813474 @default.
- W2732140867 cites W2004235434 @default.
- W2732140867 cites W2005025375 @default.
- W2732140867 cites W2005109257 @default.
- W2732140867 cites W2005119615 @default.
- W2732140867 cites W2006111363 @default.
- W2732140867 cites W2007141982 @default.
- W2732140867 cites W2009008191 @default.
- W2732140867 cites W2009523307 @default.
- W2732140867 cites W2010180179 @default.
- W2732140867 cites W2011825302 @default.
- W2732140867 cites W2011879593 @default.
- W2732140867 cites W2014617922 @default.
- W2732140867 cites W2014939186 @default.
- W2732140867 cites W2014946489 @default.
- W2732140867 cites W2016085979 @default.
- W2732140867 cites W2016772121 @default.
- W2732140867 cites W2017134039 @default.
- W2732140867 cites W2018251493 @default.
- W2732140867 cites W2018267029 @default.
- W2732140867 cites W2018986985 @default.
- W2732140867 cites W2020798985 @default.
- W2732140867 cites W2021223304 @default.
- W2732140867 cites W2022958241 @default.
- W2732140867 cites W2023722200 @default.
- W2732140867 cites W2024040797 @default.
- W2732140867 cites W2025780125 @default.
- W2732140867 cites W2026386550 @default.
- W2732140867 cites W2032073649 @default.
- W2732140867 cites W2032550419 @default.
- W2732140867 cites W2035653659 @default.
- W2732140867 cites W2038021540 @default.
- W2732140867 cites W2040317998 @default.
- W2732140867 cites W2040737652 @default.
- W2732140867 cites W2046018563 @default.
- W2732140867 cites W2047190365 @default.
- W2732140867 cites W2047401256 @default.
- W2732140867 cites W2047485743 @default.
- W2732140867 cites W2048221993 @default.
- W2732140867 cites W2050906087 @default.
- W2732140867 cites W2051238269 @default.
- W2732140867 cites W2052955900 @default.
- W2732140867 cites W2053173504 @default.
- W2732140867 cites W2055168309 @default.
- W2732140867 cites W2056574266 @default.
- W2732140867 cites W2057698117 @default.
- W2732140867 cites W2058080639 @default.
- W2732140867 cites W2058435509 @default.
- W2732140867 cites W2059021156 @default.
- W2732140867 cites W2059846555 @default.
- W2732140867 cites W2060332263 @default.