FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2732245612> ?p ?o ?g. }

• W2732245612 abstract "In recent years, the extent of our vulnerability to misinterpretation due to poorly characterized reagents has become an issue of great concern. Antibody reagents have been identified as a major source of error, contributing to the “reproducibility crisis.” In the current report, we define an additional dimension of the crisis; in particular, we define variation of the targets being analyzed. We report that natural variation in the immunoglobulin “constant” region alters the reactivity with commonly used subtype-specific anti-IgG reagents, resulting in cross-reactivity of polyclonal regents with inappropriate targets and blind spots of monoclonal reagents for desired targets. This raises the practical concern that numerous studies characterizing IgG subtypes in human disease may contain errors due to such previously unappreciated defects. These studies also focus attention on the broader concern that genetic variation may affect the performance of any laboratory or research test that uses antibodies for detection." @default.
• W2732245612 created "2017-07-14" @default.
• W2732245612 creator A5013081921 @default.
• W2732245612 creator A5041867277 @default.
• W2732245612 creator A5046574042 @default.
• W2732245612 creator A5050531343 @default.
• W2732245612 creator A5070648034 @default.
• W2732245612 creator A5086389738 @default.
• W2732245612 creator A5087932465 @default.
• W2732245612 date "2017-07-06" @default.
• W2732245612 modified "2023-09-25" @default.
• W2732245612 title "Errors in data interpretation from genetic variation of human analytes" @default.
• W2732245612 cites W1592986776 @default.
• W2732245612 cites W2015404754 @default.
• W2732245612 cites W2019565007 @default.
• W2732245612 cites W2020174941 @default.
• W2732245612 cites W2030156560 @default.
• W2732245612 cites W2046682570 @default.
• W2732245612 cites W2066961297 @default.
• W2732245612 cites W2083167820 @default.
• W2732245612 cites W2101252880 @default.
• W2732245612 cites W2122225224 @default.
• W2732245612 cites W2132187229 @default.
• W2732245612 cites W2142216869 @default.
• W2732245612 cites W2142972358 @default.
• W2732245612 cites W2159823863 @default.
• W2732245612 cites W2169656611 @default.
• W2732245612 cites W2174272851 @default.
• W2732245612 cites W24330573 @default.
• W2732245612 cites W2517860462 @default.
• W2732245612 cites W2522457666 @default.
• W2732245612 cites W2535594334 @default.
• W2732245612 cites W2624687403 @default.
• W2732245612 cites W271671269 @default.
• W2732245612 cites W3119200867 @default.
• W2732245612 cites W4240422451 @default.
• W2732245612 doi "https://doi.org/10.1172/jci.insight.94532" @default.
• W2732245612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5499359" @default.
• W2732245612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28679954" @default.
• W2732245612 hasPublicationYear "2017" @default.
• W2732245612 type Work @default.
• W2732245612 sameAs 2732245612 @default.
• W2732245612 citedByCount "6" @default.
• W2732245612 countsByYear W27322456122018 @default.
• W2732245612 countsByYear W27322456122019 @default.
• W2732245612 countsByYear W27322456122020 @default.
• W2732245612 countsByYear W27322456122022 @default.
• W2732245612 countsByYear W27322456122023 @default.
• W2732245612 crossrefType "journal-article" @default.
• W2732245612 hasAuthorship W2732245612A5013081921 @default.
• W2732245612 hasAuthorship W2732245612A5041867277 @default.
• W2732245612 hasAuthorship W2732245612A5046574042 @default.
• W2732245612 hasAuthorship W2732245612A5050531343 @default.
• W2732245612 hasAuthorship W2732245612A5070648034 @default.
• W2732245612 hasAuthorship W2732245612A5086389738 @default.
• W2732245612 hasAuthorship W2732245612A5087932465 @default.
• W2732245612 hasBestOaLocation W27322456121 @default.
• W2732245612 hasConcept C142724271 @default.
• W2732245612 hasConcept C147789679 @default.
• W2732245612 hasConcept C159654299 @default.
• W2732245612 hasConcept C185592680 @default.
• W2732245612 hasConcept C203014093 @default.
• W2732245612 hasConcept C204787440 @default.
• W2732245612 hasConcept C2776910235 @default.
• W2732245612 hasConcept C38652104 @default.
• W2732245612 hasConcept C40875361 @default.
• W2732245612 hasConcept C41008148 @default.
• W2732245612 hasConcept C542903549 @default.
• W2732245612 hasConcept C70721500 @default.
• W2732245612 hasConcept C71924100 @default.
• W2732245612 hasConcept C86803240 @default.
• W2732245612 hasConcept C956191 @default.
• W2732245612 hasConcept C95713431 @default.
• W2732245612 hasConceptScore W2732245612C142724271 @default.
• W2732245612 hasConceptScore W2732245612C147789679 @default.
• W2732245612 hasConceptScore W2732245612C159654299 @default.
• W2732245612 hasConceptScore W2732245612C185592680 @default.
• W2732245612 hasConceptScore W2732245612C203014093 @default.
• W2732245612 hasConceptScore W2732245612C204787440 @default.
• W2732245612 hasConceptScore W2732245612C2776910235 @default.
• W2732245612 hasConceptScore W2732245612C38652104 @default.
• W2732245612 hasConceptScore W2732245612C40875361 @default.
• W2732245612 hasConceptScore W2732245612C41008148 @default.
• W2732245612 hasConceptScore W2732245612C542903549 @default.
• W2732245612 hasConceptScore W2732245612C70721500 @default.
• W2732245612 hasConceptScore W2732245612C71924100 @default.
• W2732245612 hasConceptScore W2732245612C86803240 @default.
• W2732245612 hasConceptScore W2732245612C956191 @default.
• W2732245612 hasConceptScore W2732245612C95713431 @default.
• W2732245612 hasIssue "13" @default.
• W2732245612 hasLocation W27322456121 @default.
• W2732245612 hasLocation W27322456122 @default.
• W2732245612 hasLocation W27322456123 @default.
• W2732245612 hasLocation W27322456124 @default.
• W2732245612 hasOpenAccess W2732245612 @default.
• W2732245612 hasPrimaryLocation W27322456121 @default.
• W2732245612 hasRelatedWork W152087843 @default.
• W2732245612 hasRelatedWork W1989645200 @default.
• W2732245612 hasRelatedWork W2020465807 @default.
• W2732245612 hasRelatedWork W2025678534 @default.

• next