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- W2732311975 endingPage "680" @default.
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- W2732311975 abstract "Chimeric antigen receptor T-cell therapy has achieved highly promising results in clinical trials, particularly in B-cell malignancies. However, reports of serious adverse events including a number of patient deaths have raised concerns about safety of this treatment. Presently available preclinical models are not designed for predicting toxicities seen in human patients. Besides choosing the right animal model, careful considerations must be taken in chimeric antigen receptor T-cell design and the amount of T cells infused. The development of more sophisticated in vitro models and humanized mouse models for preclinical modeling and toxicity tests will help us to improve the design of clinical trials in cancer immunotherapy." @default.
- W2732311975 created "2017-07-14" @default.
- W2732311975 creator A5047509420 @default.
- W2732311975 date "2017-06-01" @default.
- W2732311975 modified "2023-10-18" @default.
- W2732311975 title "Chimeric antigen receptor T cells for the treatment of cancer and the future of preclinical models for predicting their toxicities" @default.
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- W2732311975 doi "https://doi.org/10.2217/imt-2017-0028" @default.
- W2732311975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28653571" @default.
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