Matches in SemOpenAlex for { <https://semopenalex.org/work/W2732788045> ?p ?o ?g. }
- W2732788045 abstract "Abstract LINE-1/L1 retrotransposon sequences comprise 17% of the human genome. Among the many classes of mobile genetic elements, L1 is the only autonomous retrotransposon that still drives human genomic plasticity today. Through its co-evolution with the human genome, L1 has intertwined itself with host cell biology to aid its proliferation. However, a clear understanding of L1’s lifecycle and the processes involved in restricting its insertion and its intragenomic spreading remains elusive. Here we identify modes of L1 proteins’ entrance into the nucleus, a necessary step for L1 proliferation. Using functional, biochemical, and imaging approaches, we also show a clear cell cycle bias for L1 retrotransposition that peaks during the S phase. Our observations provide a basis for novel interpretations about the nature of nuclear and cytoplasmic L1 ribonucleoproteins (RNPs) and the potential role of DNA replication in L1 retrotransposition." @default.
- W2732788045 created "2017-07-14" @default.
- W2732788045 creator A5002103371 @default.
- W2732788045 creator A5030974127 @default.
- W2732788045 creator A5039346329 @default.
- W2732788045 creator A5044222979 @default.
- W2732788045 creator A5046100379 @default.
- W2732788045 creator A5046586712 @default.
- W2732788045 creator A5054545550 @default.
- W2732788045 creator A5065792746 @default.
- W2732788045 creator A5072995500 @default.
- W2732788045 creator A5075536007 @default.
- W2732788045 creator A5081670628 @default.
- W2732788045 creator A5090746916 @default.
- W2732788045 date "2017-06-30" @default.
- W2732788045 modified "2023-10-14" @default.
- W2732788045 title "LINE-1 and the cell cycle: protein localization and functional dynamics" @default.
- W2732788045 cites W1898603749 @default.
- W2732788045 cites W1964567249 @default.
- W2732788045 cites W1965141089 @default.
- W2732788045 cites W1965813248 @default.
- W2732788045 cites W1967266019 @default.
- W2732788045 cites W1971436187 @default.
- W2732788045 cites W1976490712 @default.
- W2732788045 cites W1977709885 @default.
- W2732788045 cites W1978596306 @default.
- W2732788045 cites W1981915622 @default.
- W2732788045 cites W1984933368 @default.
- W2732788045 cites W1986319478 @default.
- W2732788045 cites W1991333931 @default.
- W2732788045 cites W1991719330 @default.
- W2732788045 cites W1994762762 @default.
- W2732788045 cites W1995149647 @default.
- W2732788045 cites W1996435746 @default.
- W2732788045 cites W1999494370 @default.
- W2732788045 cites W1999884745 @default.
- W2732788045 cites W2007589425 @default.
- W2732788045 cites W2007780767 @default.
- W2732788045 cites W2013770032 @default.
- W2732788045 cites W2018086201 @default.
- W2732788045 cites W2020271342 @default.
- W2732788045 cites W2027853473 @default.
- W2732788045 cites W2050240034 @default.
- W2732788045 cites W2050510928 @default.
- W2732788045 cites W2056447191 @default.
- W2732788045 cites W2076699592 @default.
- W2732788045 cites W2086197758 @default.
- W2732788045 cites W2088850825 @default.
- W2732788045 cites W2089867788 @default.
- W2732788045 cites W2096173332 @default.
- W2732788045 cites W2098474039 @default.
- W2732788045 cites W2099487576 @default.
- W2732788045 cites W2102773855 @default.
- W2732788045 cites W2104384770 @default.
- W2732788045 cites W2105199418 @default.
- W2732788045 cites W2109470020 @default.
- W2732788045 cites W2114766453 @default.
- W2732788045 cites W2116394990 @default.
- W2732788045 cites W2124999206 @default.
- W2732788045 cites W2125957866 @default.
- W2732788045 cites W2126686784 @default.
- W2732788045 cites W2127738945 @default.
- W2732788045 cites W2129788878 @default.
- W2732788045 cites W2136295423 @default.
- W2732788045 cites W2144216698 @default.
- W2732788045 cites W2146146418 @default.
- W2732788045 cites W2147198482 @default.
- W2732788045 cites W2150800455 @default.
- W2732788045 cites W2152930453 @default.
- W2732788045 cites W2156847772 @default.
- W2732788045 cites W2158195234 @default.
- W2732788045 cites W2160548451 @default.
- W2732788045 cites W2167279371 @default.
- W2732788045 cites W2167815875 @default.
- W2732788045 cites W2168676279 @default.
- W2732788045 cites W2182803741 @default.
- W2732788045 cites W2210213181 @default.
- W2732788045 cites W2213777869 @default.
- W2732788045 cites W2250444924 @default.
- W2732788045 cites W2253016623 @default.
- W2732788045 cites W2271055579 @default.
- W2732788045 cites W2411502101 @default.
- W2732788045 cites W2464251459 @default.
- W2732788045 cites W2516620605 @default.
- W2732788045 cites W2536806466 @default.
- W2732788045 cites W2550034669 @default.
- W2732788045 cites W2566189817 @default.
- W2732788045 cites W798143013 @default.
- W2732788045 cites W81831641 @default.
- W2732788045 doi "https://doi.org/10.1101/147587" @default.
- W2732788045 hasPublicationYear "2017" @default.
- W2732788045 type Work @default.
- W2732788045 sameAs 2732788045 @default.
- W2732788045 citedByCount "2" @default.
- W2732788045 countsByYear W27327880452018 @default.
- W2732788045 countsByYear W27327880452022 @default.
- W2732788045 crossrefType "posted-content" @default.
- W2732788045 hasAuthorship W2732788045A5002103371 @default.
- W2732788045 hasAuthorship W2732788045A5030974127 @default.
- W2732788045 hasAuthorship W2732788045A5039346329 @default.