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- W2733125364 endingPage "701" @default.
- W2733125364 startingPage "686" @default.
- W2733125364 abstract "Abstract The spectrum of activity of vitamin D goes beyond calcium and bone homeostasis, and growing evidence suggests that vitamin D contributes to maintain musculoskeletal health in healthy subjects as well as in patients with chronic kidney disease (CKD), who display the combination of bone metabolism disorder, muscle wasting, and weakness. Here, we review how vitamin D represents a pathway in which bone and muscle may interact. In vitro studies have confirmed that the vitamin D receptor is present on muscle, describing the mechanisms whereby vitamin D directly affects skeletal muscle. These include genomic and non‐genomic (rapid) effects, regulating cellular differentiation and proliferation. Observational studies have shown that circulating 25‐hydroxyvitamin D levels correlate with the clinical symptoms and muscle morphological changes observed in CKD patients. Vitamin D deficiency has been linked to low bone formation rate and bone mineral density, with an increased risk of skeletal fractures. The impact of low vitamin D status on skeletal muscle may also affect muscle metabolic pathways, including its sensitivity to insulin. Although some interventional studies have shown that vitamin D may improve physical performance and protect against the development of histological and radiological signs of hyperparathyroidism, evidence is still insufficient to draw definitive conclusions." @default.
- W2733125364 created "2017-07-14" @default.
- W2733125364 creator A5018320268 @default.
- W2733125364 creator A5048010165 @default.
- W2733125364 creator A5053537325 @default.
- W2733125364 creator A5058768914 @default.
- W2733125364 creator A5078942933 @default.
- W2733125364 creator A5080009012 @default.
- W2733125364 date "2017-07-03" @default.
- W2733125364 modified "2023-10-14" @default.
- W2733125364 title "Vitamin D, a modulator of musculoskeletal health in chronic kidney disease" @default.
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