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- W2733133586 endingPage "1206" @default.
- W2733133586 startingPage "1197" @default.
- W2733133586 abstract "Purpose: Low-dose radiation has various biological effects such as adaptive responses, low-dose hypersensitivity, as well as beneficial effects. However, little is known about the particular proteins involved in these effects. Here, we sought to identify low-dose radiation-responsive phosphoproteins in normal fibroblast cells.Materials and methods: We assessed genomic instability and proliferation of fibroblast cells after γ-irradiation by γ-H2AX foci and micronucleus formation analyses and BrdU incorporation assay, respectively. We screened fibroblast cells 8 h after low-dose (0.05 Gy) γ-irradiation using Phospho Explorer Antibody Microarray and validated two differentially expressed phosphoproteins using Western blotting.Results: Cell proliferation proceeded normally in the absence of genomic instability after low-dose γ-irradiation. Phospho antibody microarray analysis and Western blotting revealed increased expression of two phosphoproteins, phospho-NFκB (Ser536) and phospho-P70S6K (Ser418), 8 h after low-dose radiation.Conclusions: Our findings suggest that low-dose radiation of normal fibroblast cells activates the expression of phospho-NFκB (Ser536) and phospho-P70S6K (Ser418) in the absence of genomic instability. Therefore, these proteins may be involved in DNA damage repair processes." @default.
- W2733133586 created "2017-07-14" @default.
- W2733133586 creator A5027080984 @default.
- W2733133586 creator A5058880491 @default.
- W2733133586 creator A5062891106 @default.
- W2733133586 creator A5071118509 @default.
- W2733133586 creator A5082774044 @default.
- W2733133586 date "2017-07-25" @default.
- W2733133586 modified "2023-09-25" @default.
- W2733133586 title "Estimation of low-dose radiation-responsive proteins in the absence of genomic instability in normal human fibroblast cells" @default.
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- W2733133586 doi "https://doi.org/10.1080/09553002.2017.1350302" @default.
- W2733133586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28681635" @default.
- W2733133586 hasPublicationYear "2017" @default.
- W2733133586 type Work @default.