FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2733440441> ?p ?o ?g. }

• W2733440441 abstract "Abstract Background: Human kallikrein-related peptidase 6 (KLK6) is a member of the kallikrein family of serine proteases. KLK6 is synthesized as a preproenzyme, mainly in tissues of the central nervous system (CNS), and secreted as an inactive precursor. Serum KLK6 is a biomarker of unfavorable prognosis for ovarian cancer, but its sensitivity for early detection is relatively low. Differential glycosylation of KLK6 has been identified in ascites fluid obtained from ovarian cancer patients, suggesting the presence of unique KLK6 isoforms in biological samples. Methods: In the present study, we applied a two-step enrichment approach for KLK6 in ovarian cancer ascites, followed by mice immunization and production of monoclonal antibodies. Immunoaffinity techniques coupled to mass spectrometric methods were employed for hybridoma screening and target antigen identification. Results: We found that the main target of the newly-generated monoclonal antibodies target was the serine protease inhibitor α Conclusions: We conclude that KLK6 is present in biological fluids either as free form, or bound to A1AT, and the bound form performs better than total KLK6 as a biomarker of ovarian carcinoma." @default.
• W2733440441 created "2017-07-14" @default.
• W2733440441 creator A5066989467 @default.
• W2733440441 creator A5084226800 @default.
• W2733440441 creator A5084733643 @default.
• W2733440441 date "2017-01-01" @default.
• W2733440441 modified "2023-10-17" @default.
• W2733440441 title "Study of kallikrein-related peptidase 6 (KLK6) and its complex with α1-antitrypsin in biological fluids" @default.
• W2733440441 cites W1484454235 @default.
• W2733440441 cites W1671238747 @default.
• W2733440441 cites W1953569147 @default.
• W2733440441 cites W1979141341 @default.
• W2733440441 cites W1981122746 @default.
• W2733440441 cites W1982149110 @default.
• W2733440441 cites W1989536974 @default.
• W2733440441 cites W1995522704 @default.
• W2733440441 cites W1996298454 @default.
• W2733440441 cites W1997870903 @default.
• W2733440441 cites W2006122379 @default.
• W2733440441 cites W2015278187 @default.
• W2733440441 cites W2020670793 @default.
• W2733440441 cites W2039920498 @default.
• W2733440441 cites W2075744249 @default.
• W2733440441 cites W2080752012 @default.
• W2733440441 cites W2082635888 @default.
• W2733440441 cites W2086641526 @default.
• W2733440441 cites W2088585910 @default.
• W2733440441 cites W2096789359 @default.
• W2733440441 cites W2100048800 @default.
• W2733440441 cites W2102948567 @default.
• W2733440441 cites W2109602297 @default.
• W2733440441 cites W2110337690 @default.
• W2733440441 cites W2117073162 @default.
• W2733440441 cites W2131730392 @default.
• W2733440441 cites W2132058414 @default.
• W2733440441 cites W2143855087 @default.
• W2733440441 cites W2144024213 @default.
• W2733440441 cites W2150499072 @default.
• W2733440441 cites W2152460504 @default.
• W2733440441 cites W2154688757 @default.
• W2733440441 cites W2166919355 @default.
• W2733440441 cites W2170798480 @default.
• W2733440441 cites W2171364265 @default.
• W2733440441 cites W2172116519 @default.
• W2733440441 cites W2235523093 @default.
• W2733440441 cites W2463195069 @default.
• W2733440441 cites W2472989101 @default.
• W2733440441 cites W2493518155 @default.
• W2733440441 cites W2549204523 @default.
• W2733440441 cites W4294107304 @default.
• W2733440441 doi "https://doi.org/10.1515/cclm-2017-0017" @default.
• W2733440441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28672746" @default.
• W2733440441 hasPublicationYear "2017" @default.
• W2733440441 type Work @default.
• W2733440441 sameAs 2733440441 @default.
• W2733440441 citedByCount "8" @default.
• W2733440441 countsByYear W27334404412018 @default.
• W2733440441 countsByYear W27334404412020 @default.
• W2733440441 countsByYear W27334404412021 @default.
• W2733440441 countsByYear W27334404412022 @default.
• W2733440441 countsByYear W27334404412023 @default.
• W2733440441 crossrefType "journal-article" @default.
• W2733440441 hasAuthorship W2733440441A5066989467 @default.
• W2733440441 hasAuthorship W2733440441A5084226800 @default.
• W2733440441 hasAuthorship W2733440441A5084733643 @default.
• W2733440441 hasConcept C121608353 @default.
• W2733440441 hasConcept C126322002 @default.
• W2733440441 hasConcept C147483822 @default.
• W2733440441 hasConcept C153911025 @default.
• W2733440441 hasConcept C159654299 @default.
• W2733440441 hasConcept C181199279 @default.
• W2733440441 hasConcept C182220744 @default.
• W2733440441 hasConcept C185592680 @default.
• W2733440441 hasConcept C203014093 @default.
• W2733440441 hasConcept C2776714187 @default.
• W2733440441 hasConcept C2777313579 @default.
• W2733440441 hasConcept C2777807008 @default.
• W2733440441 hasConcept C2780427987 @default.
• W2733440441 hasConcept C2781197716 @default.
• W2733440441 hasConcept C502942594 @default.
• W2733440441 hasConcept C52853521 @default.
• W2733440441 hasConcept C542903549 @default.
• W2733440441 hasConcept C55493867 @default.
• W2733440441 hasConcept C71924100 @default.
• W2733440441 hasConcept C86803240 @default.
• W2733440441 hasConceptScore W2733440441C121608353 @default.
• W2733440441 hasConceptScore W2733440441C126322002 @default.
• W2733440441 hasConceptScore W2733440441C147483822 @default.
• W2733440441 hasConceptScore W2733440441C153911025 @default.
• W2733440441 hasConceptScore W2733440441C159654299 @default.
• W2733440441 hasConceptScore W2733440441C181199279 @default.
• W2733440441 hasConceptScore W2733440441C182220744 @default.
• W2733440441 hasConceptScore W2733440441C185592680 @default.
• W2733440441 hasConceptScore W2733440441C203014093 @default.
• W2733440441 hasConceptScore W2733440441C2776714187 @default.
• W2733440441 hasConceptScore W2733440441C2777313579 @default.
• W2733440441 hasConceptScore W2733440441C2777807008 @default.
• W2733440441 hasConceptScore W2733440441C2780427987 @default.
• W2733440441 hasConceptScore W2733440441C2781197716 @default.
• W2733440441 hasConceptScore W2733440441C502942594 @default.

• next