Matches in SemOpenAlex for { <https://semopenalex.org/work/W2733451318> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2733451318 abstract "The objective of the present investigation was to identify a suitable raft forming agent and to develop raft forming stavudine matrix tablets using different rate controlling natural, semi-synthetic and synthetic polymers to achieve prolonged gastric residence time, leading to an increase in drug bioavailability and patient compliance. Various raft forming agents were used in preliminary screening. Raft forming floating tablets were developed using pullulan gum as natural rate controlling polymer, and directly compressible grades of hydroxypropyl methylcellulose (Benecel K4M DC) as semi synthetic, and Carbopol 71G as synthetic rate controlling polymers respectively and optimum concentrations of sodium-bicarbonate as gas generating agent to generate optimum buoyancy by direct compression method. Raft forming tablets were evaluated for weight variation, thickness, hardness, friability, drug content, in vitro drug release, floating buoyancy and raft strength. Drug-excipients compatibility study showed no interaction between drug and excipients. Raft forming tablets showed satisfactory results when evaluated for weight variation, thickness, hardness, friability, drug content, and raft strength. The optimized formulation was selected based on physicochemical characteristics and in vitro drug dissolution characteristics. Further, the optimized formulation was evaluated for in vivo radiographic studies by incorporating BaSO4 as radio opaque substance. Optimized formulation showed controlled and prolonged drug release profiles while floating and raft formation over the dissolution medium. Diffusion followed by erosion with raft forming drug release mechanism was observed for the formulation, indicating that dissolution media diffusion and polymer erosion played an essential role in drug release. In vivo radiographic studies revealed that the raft forming formulations remained in the stomach for 240 30 min in rabbits and indicated that gastric retention time was increased by the floating and raft forming principle, which was considered and desirable for absorption window drugs." @default.
- W2733451318 created "2017-07-14" @default.
- W2733451318 creator A5007383664 @default.
- W2733451318 creator A5045642586 @default.
- W2733451318 date "2017-01-30" @default.
- W2733451318 modified "2023-10-18" @default.
- W2733451318 title "Development and in vitro Characterization of Gastro Retentive Raft Forming Stavudine Tablets" @default.
- W2733451318 doi "https://doi.org/10.25004/ijpsdr.2017.090101" @default.
- W2733451318 hasPublicationYear "2017" @default.
- W2733451318 type Work @default.
- W2733451318 sameAs 2733451318 @default.
- W2733451318 citedByCount "0" @default.
- W2733451318 crossrefType "journal-article" @default.
- W2733451318 hasAuthorship W2733451318A5007383664 @default.
- W2733451318 hasAuthorship W2733451318A5045642586 @default.
- W2733451318 hasBestOaLocation W27334513181 @default.
- W2733451318 hasConcept C127413603 @default.
- W2733451318 hasConcept C15920480 @default.
- W2733451318 hasConcept C159985019 @default.
- W2733451318 hasConcept C178790620 @default.
- W2733451318 hasConcept C185592680 @default.
- W2733451318 hasConcept C191168616 @default.
- W2733451318 hasConcept C192562407 @default.
- W2733451318 hasConcept C2776035855 @default.
- W2733451318 hasConcept C2776725572 @default.
- W2733451318 hasConcept C42360764 @default.
- W2733451318 hasConcept C43617362 @default.
- W2733451318 hasConcept C521977710 @default.
- W2733451318 hasConcept C55493867 @default.
- W2733451318 hasConcept C88380143 @default.
- W2733451318 hasConcept C9132879 @default.
- W2733451318 hasConceptScore W2733451318C127413603 @default.
- W2733451318 hasConceptScore W2733451318C15920480 @default.
- W2733451318 hasConceptScore W2733451318C159985019 @default.
- W2733451318 hasConceptScore W2733451318C178790620 @default.
- W2733451318 hasConceptScore W2733451318C185592680 @default.
- W2733451318 hasConceptScore W2733451318C191168616 @default.
- W2733451318 hasConceptScore W2733451318C192562407 @default.
- W2733451318 hasConceptScore W2733451318C2776035855 @default.
- W2733451318 hasConceptScore W2733451318C2776725572 @default.
- W2733451318 hasConceptScore W2733451318C42360764 @default.
- W2733451318 hasConceptScore W2733451318C43617362 @default.
- W2733451318 hasConceptScore W2733451318C521977710 @default.
- W2733451318 hasConceptScore W2733451318C55493867 @default.
- W2733451318 hasConceptScore W2733451318C88380143 @default.
- W2733451318 hasConceptScore W2733451318C9132879 @default.
- W2733451318 hasLocation W27334513181 @default.
- W2733451318 hasOpenAccess W2733451318 @default.
- W2733451318 hasPrimaryLocation W27334513181 @default.
- W2733451318 hasRelatedWork W1596611573 @default.
- W2733451318 hasRelatedWork W2004356977 @default.
- W2733451318 hasRelatedWork W2103308013 @default.
- W2733451318 hasRelatedWork W2166285240 @default.
- W2733451318 hasRelatedWork W2184789976 @default.
- W2733451318 hasRelatedWork W2189621388 @default.
- W2733451318 hasRelatedWork W2324955418 @default.
- W2733451318 hasRelatedWork W2584969840 @default.
- W2733451318 hasRelatedWork W2616631483 @default.
- W2733451318 hasRelatedWork W2740503135 @default.
- W2733451318 hasRelatedWork W2742544902 @default.
- W2733451318 hasRelatedWork W2745188710 @default.
- W2733451318 hasRelatedWork W2993519652 @default.
- W2733451318 hasRelatedWork W3165145047 @default.
- W2733451318 hasRelatedWork W2181624290 @default.
- W2733451318 hasRelatedWork W2182557472 @default.
- W2733451318 hasRelatedWork W2187175629 @default.
- W2733451318 hasRelatedWork W2326723402 @default.
- W2733451318 hasRelatedWork W2495480397 @default.
- W2733451318 hasRelatedWork W2944526226 @default.
- W2733451318 isParatext "false" @default.
- W2733451318 isRetracted "false" @default.
- W2733451318 magId "2733451318" @default.
- W2733451318 workType "article" @default.