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- W2733452440 abstract "Complexity abounds in cell biology. For instance it shows up in the number and the organization of eucaryotic signal transduction pathways. So far as many as eleven MAP kinase family members have been identified in mammalian cells. They constitute different groups of kinases that are involved in different signal transducing pathways [1]. These signal transduction pathways provide the cell with a structured informational processing machinery processing multiple signals at the same time. The result is an integrated adaptive response of the cell towards the signals mediated by activation of a diverse range of transcription factors. Due to non-linearity prevailing in the kinetics of signal transduction pathways, various emergent properties might arise. One is the ultrasensitivity of the phosphorylated enzyme concentration towards the concentration of the signal, implying the existence of a threshold response below which the system does not respond [2]. The extent of ultrasensitivity can be quantified using the concentration response coefficient of the phosphorylated enzyme with respect to its signal, complying with metabolic control analysis [3,4]. Another interesting emergent property is the possible existence of two steady states a phenomenon known as bistability [5,6,7]. Bistability in signal transduction networks results in two attainable stable steady states characterized by different active regulatory protein concentrations. This may invoke different physiological states or cellular differentiation [7]. The steady state the system will ultimately evolve to depends upon the history of the system, e.g., on its initial conditions. The possibility of bistability in signal transduction has been acknowledged in the literature [5,6,7]. However, to date, this" @default.
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- W2733452440 date "2000-01-01" @default.
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- W2733452440 title "Is the signal transduction network emanating from the EGP receptor bistable in vivo" @default.
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