Matches in SemOpenAlex for { <https://semopenalex.org/work/W2733508746> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2733508746 endingPage "307" @default.
- W2733508746 startingPage "302" @default.
- W2733508746 abstract "In the nervous system, four calcium/calcineurin-regulated members of the nuclear factor of activated T-cells (NFAT) family of transcription factors, NFATc1-c4, are involved in many developmental and functional processes, such as corticogenesis, synaptogenesis, synaptic plasticity and neurotransmission, that all need precise gene regulation. Therefore it is important to understand molecular events that contribute to the regulation of the transcriptional activity of specific NFAT isoforms. Previously, we have shown that there are a number of alternative splice variants of NFAT genes expressed in the brain and that neuronal activity leads to isoform-specific transactivation capacities of different human NFAT proteins. Here we looked at the effect of sumoylation as a possible regulator of the transcriptional activity of different human NFAT isoforms in rat primary cortical and hippocampal neurons in response to membrane depolarization and compared the results to those obtained from non-neuronal HEK293-FT and BHK-21 cells in response to calcium signaling. Our results show that in primary hippocampal neurons, sumoylation represses the transcriptional activity of NFATc1, NFATc2, and NFATc3 isoforms, whereas in cortical neurons, transactivation capacity of only NFATc1 and NFATc2 is repressed by sumoylation. In non-neuronal cells, however, transcriptional activity of all four NFAT isoforms is repressed by sumoylation in HEK293-FT cells, while only NFATc1 and NFATc2 isoforms are affected by sumoylation in BHK-21 cells. Altogether, our results show that sumoylation represses the transcription activation capacities of NFAT isoforms and that the effect is cell type-specific." @default.
- W2733508746 created "2017-07-14" @default.
- W2733508746 creator A5014174188 @default.
- W2733508746 creator A5085523698 @default.
- W2733508746 date "2017-07-01" @default.
- W2733508746 modified "2023-10-06" @default.
- W2733508746 title "Sumoylation regulates the transcriptional activity of different human NFAT isoforms in neurons" @default.
- W2733508746 cites W1874089557 @default.
- W2733508746 cites W1972796654 @default.
- W2733508746 cites W1975092906 @default.
- W2733508746 cites W1979503919 @default.
- W2733508746 cites W1991189921 @default.
- W2733508746 cites W1997822424 @default.
- W2733508746 cites W2005193904 @default.
- W2733508746 cites W2033537045 @default.
- W2733508746 cites W2082418190 @default.
- W2733508746 cites W2110150849 @default.
- W2733508746 cites W2127322768 @default.
- W2733508746 cites W2295300743 @default.
- W2733508746 cites W2325074909 @default.
- W2733508746 cites W2338118586 @default.
- W2733508746 cites W2490844245 @default.
- W2733508746 cites W2509566856 @default.
- W2733508746 doi "https://doi.org/10.1016/j.neulet.2017.05.074" @default.
- W2733508746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28595951" @default.
- W2733508746 hasPublicationYear "2017" @default.
- W2733508746 type Work @default.
- W2733508746 sameAs 2733508746 @default.
- W2733508746 citedByCount "9" @default.
- W2733508746 countsByYear W27335087462017 @default.
- W2733508746 countsByYear W27335087462018 @default.
- W2733508746 countsByYear W27335087462019 @default.
- W2733508746 countsByYear W27335087462020 @default.
- W2733508746 countsByYear W27335087462021 @default.
- W2733508746 countsByYear W27335087462022 @default.
- W2733508746 crossrefType "journal-article" @default.
- W2733508746 hasAuthorship W2733508746A5014174188 @default.
- W2733508746 hasAuthorship W2733508746A5085523698 @default.
- W2733508746 hasConcept C104317684 @default.
- W2733508746 hasConcept C1292079 @default.
- W2733508746 hasConcept C165864922 @default.
- W2733508746 hasConcept C171350616 @default.
- W2733508746 hasConcept C174510640 @default.
- W2733508746 hasConcept C189938988 @default.
- W2733508746 hasConcept C194583182 @default.
- W2733508746 hasConcept C25602115 @default.
- W2733508746 hasConcept C53345823 @default.
- W2733508746 hasConcept C54355233 @default.
- W2733508746 hasConcept C65232495 @default.
- W2733508746 hasConcept C86339819 @default.
- W2733508746 hasConcept C86803240 @default.
- W2733508746 hasConcept C95444343 @default.
- W2733508746 hasConceptScore W2733508746C104317684 @default.
- W2733508746 hasConceptScore W2733508746C1292079 @default.
- W2733508746 hasConceptScore W2733508746C165864922 @default.
- W2733508746 hasConceptScore W2733508746C171350616 @default.
- W2733508746 hasConceptScore W2733508746C174510640 @default.
- W2733508746 hasConceptScore W2733508746C189938988 @default.
- W2733508746 hasConceptScore W2733508746C194583182 @default.
- W2733508746 hasConceptScore W2733508746C25602115 @default.
- W2733508746 hasConceptScore W2733508746C53345823 @default.
- W2733508746 hasConceptScore W2733508746C54355233 @default.
- W2733508746 hasConceptScore W2733508746C65232495 @default.
- W2733508746 hasConceptScore W2733508746C86339819 @default.
- W2733508746 hasConceptScore W2733508746C86803240 @default.
- W2733508746 hasConceptScore W2733508746C95444343 @default.
- W2733508746 hasFunder F4320321090 @default.
- W2733508746 hasFunder F4320335322 @default.
- W2733508746 hasLocation W27335087461 @default.
- W2733508746 hasLocation W27335087462 @default.
- W2733508746 hasOpenAccess W2733508746 @default.
- W2733508746 hasPrimaryLocation W27335087461 @default.
- W2733508746 hasRelatedWork W1552859974 @default.
- W2733508746 hasRelatedWork W1750867529 @default.
- W2733508746 hasRelatedWork W2010066213 @default.
- W2733508746 hasRelatedWork W2040891426 @default.
- W2733508746 hasRelatedWork W2106366918 @default.
- W2733508746 hasRelatedWork W2114719792 @default.
- W2733508746 hasRelatedWork W2180308778 @default.
- W2733508746 hasRelatedWork W2581151026 @default.
- W2733508746 hasRelatedWork W2733508746 @default.
- W2733508746 hasRelatedWork W4286698621 @default.
- W2733508746 hasVolume "653" @default.
- W2733508746 isParatext "false" @default.
- W2733508746 isRetracted "false" @default.
- W2733508746 magId "2733508746" @default.
- W2733508746 workType "article" @default.