Matches in SemOpenAlex for { <https://semopenalex.org/work/W2733565377> ?p ?o ?g. }
- W2733565377 abstract "The human cerebral cortex is the seat of our cognitive abilities and composed of an extraordinary number of neurons, organized in six distinct layers. The establishment of specific morphological and physiological features in individual neurons needs to be regulated with high precision. Impairments in the sequential developmental programs instructing corticogenesis lead to alterations in the cortical cytoarchitecture which is thought to represent the major underlying cause for several neurological disorders including neurodevelopmental and psychiatric diseases. In this review we discuss the role of cell polarity at sequential stages during cortex development. We first provide an overview of morphological cell polarity features in cortical neural stem cells and newly-born postmitotic neurons. We then synthesize a conceptual molecular and biochemical framework how cell polarity is established at the cellular level through a break in symmetry in nascent cortical projection neurons. Lastly we provide a perspective how the molecular mechanisms applying to single cells could be probed and integrated in an in vivo and tissue-wide context." @default.
- W2733565377 created "2017-07-14" @default.
- W2733565377 creator A5015595521 @default.
- W2733565377 creator A5035000468 @default.
- W2733565377 creator A5045127741 @default.
- W2733565377 creator A5052596523 @default.
- W2733565377 creator A5080499335 @default.
- W2733565377 date "2017-06-28" @default.
- W2733565377 modified "2023-10-15" @default.
- W2733565377 title "Cell Polarity in Cerebral Cortex Development—Cellular Architecture Shaped by Biochemical Networks" @default.
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