Matches in SemOpenAlex for { <https://semopenalex.org/work/W2733633287> ?p ?o ?g. }
- W2733633287 endingPage "235" @default.
- W2733633287 startingPage "229" @default.
- W2733633287 abstract "To evaluate the effects of baicalin in human gastric cancer cells, including apoptosis-inducing effects, and to investigate its underlying mechanisms of action. Cell proliferation and apoptosis assays were performed to investigate the anti-proliferation effects of baicalin in human gastric cancer BGC-823 and MGC-803 cells. Real time-quantitative polymerase chain reaction and Western blotting analysis were performed to elucidate the molecular mechanisms underlying the anti-tumor properties of baicalin. In BGC-823 and MGC-803 gastric cancer cells treated with 80, 120, and 160 µmol/L baicalin for 48 h, a 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay showed that baicalin significantly inhibited cell proliferation in a dose-dependent manner, while flow cytometric analysis demonstrated that baicalin could induce apoptosis, also in a dose-dependent manner. Moreover, baicalin up-regulated the expression of caspase-3, caspase-9, and B cell lymphoma (Bcl-2)-associated X protein and down-regulated the expression of Bcl-2 at both the mRNA and protein level. Baicalin has potential as a therapeutic agent for gastric cancer by inducing apoptosis in cancer cells." @default.
- W2733633287 created "2017-07-14" @default.
- W2733633287 creator A5015792001 @default.
- W2733633287 creator A5036072908 @default.
- W2733633287 creator A5044514611 @default.
- W2733633287 creator A5048927086 @default.
- W2733633287 creator A5050856927 @default.
- W2733633287 creator A5064487640 @default.
- W2733633287 creator A5066673597 @default.
- W2733633287 creator A5069808800 @default.
- W2733633287 date "2017-04-01" @default.
- W2733633287 modified "2023-09-28" @default.
- W2733633287 title "Baicalin extracted from Huang qin ( Radix Scutellariae Baicalensis ) induces apoptosis in gastric cancer cells by regulating B cell lymphoma (Bcl-2)/Bcl-2-associated X protein and activating caspase-3 and caspase-9" @default.
- W2733633287 cites W1971411560 @default.
- W2733633287 cites W1974241074 @default.
- W2733633287 cites W1980483408 @default.
- W2733633287 cites W1983472990 @default.
- W2733633287 cites W1984699508 @default.
- W2733633287 cites W1986773182 @default.
- W2733633287 cites W1990658677 @default.
- W2733633287 cites W2002367078 @default.
- W2733633287 cites W2003800993 @default.
- W2733633287 cites W2005084937 @default.
- W2733633287 cites W2024405339 @default.
- W2733633287 cites W2037891478 @default.
- W2733633287 cites W2041697397 @default.
- W2733633287 cites W2060225624 @default.
- W2733633287 cites W2067012525 @default.
- W2733633287 cites W2081211388 @default.
- W2733633287 cites W2094624294 @default.
- W2733633287 cites W2095426065 @default.
- W2733633287 cites W2097786201 @default.
- W2733633287 cites W2102987985 @default.
- W2733633287 cites W2108100488 @default.
- W2733633287 cites W2111423476 @default.
- W2733633287 cites W2117692326 @default.
- W2733633287 cites W2134387658 @default.
- W2733633287 cites W2152728586 @default.
- W2733633287 cites W2159930031 @default.
- W2733633287 cites W2164544843 @default.
- W2733633287 cites W2170238898 @default.
- W2733633287 doi "https://doi.org/10.1016/s0254-6272(17)30049-3" @default.
- W2733633287 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29960296" @default.
- W2733633287 hasPublicationYear "2017" @default.
- W2733633287 type Work @default.
- W2733633287 sameAs 2733633287 @default.
- W2733633287 citedByCount "13" @default.
- W2733633287 countsByYear W27336332872018 @default.
- W2733633287 countsByYear W27336332872019 @default.
- W2733633287 countsByYear W27336332872020 @default.
- W2733633287 countsByYear W27336332872021 @default.
- W2733633287 countsByYear W27336332872022 @default.
- W2733633287 countsByYear W27336332872023 @default.
- W2733633287 crossrefType "journal-article" @default.
- W2733633287 hasAuthorship W2733633287A5015792001 @default.
- W2733633287 hasAuthorship W2733633287A5036072908 @default.
- W2733633287 hasAuthorship W2733633287A5044514611 @default.
- W2733633287 hasAuthorship W2733633287A5048927086 @default.
- W2733633287 hasAuthorship W2733633287A5050856927 @default.
- W2733633287 hasAuthorship W2733633287A5064487640 @default.
- W2733633287 hasAuthorship W2733633287A5066673597 @default.
- W2733633287 hasAuthorship W2733633287A5069808800 @default.
- W2733633287 hasBestOaLocation W27336332871 @default.
- W2733633287 hasConcept C104317684 @default.
- W2733633287 hasConcept C121608353 @default.
- W2733633287 hasConcept C12519072 @default.
- W2733633287 hasConcept C126322002 @default.
- W2733633287 hasConcept C142724271 @default.
- W2733633287 hasConcept C153911025 @default.
- W2733633287 hasConcept C179998833 @default.
- W2733633287 hasConcept C185592680 @default.
- W2733633287 hasConcept C188947578 @default.
- W2733633287 hasConcept C190283241 @default.
- W2733633287 hasConcept C203014093 @default.
- W2733633287 hasConcept C204787440 @default.
- W2733633287 hasConcept C2778153525 @default.
- W2733633287 hasConcept C2779338263 @default.
- W2733633287 hasConcept C2780113650 @default.
- W2733633287 hasConcept C31573885 @default.
- W2733633287 hasConcept C43617362 @default.
- W2733633287 hasConcept C502942594 @default.
- W2733633287 hasConcept C55493867 @default.
- W2733633287 hasConcept C62112901 @default.
- W2733633287 hasConcept C71924100 @default.
- W2733633287 hasConcept C85265743 @default.
- W2733633287 hasConcept C86803240 @default.
- W2733633287 hasConcept C96232424 @default.
- W2733633287 hasConcept C98274493 @default.
- W2733633287 hasConcept C98424977 @default.
- W2733633287 hasConceptScore W2733633287C104317684 @default.
- W2733633287 hasConceptScore W2733633287C121608353 @default.
- W2733633287 hasConceptScore W2733633287C12519072 @default.
- W2733633287 hasConceptScore W2733633287C126322002 @default.
- W2733633287 hasConceptScore W2733633287C142724271 @default.
- W2733633287 hasConceptScore W2733633287C153911025 @default.
- W2733633287 hasConceptScore W2733633287C179998833 @default.
- W2733633287 hasConceptScore W2733633287C185592680 @default.
- W2733633287 hasConceptScore W2733633287C188947578 @default.