Matches in SemOpenAlex for { <https://semopenalex.org/work/W2733690549> ?p ?o ?g. }
- W2733690549 abstract "Eukaryotes and prokaryotes last shared a common ancestor ~2 billion years ago, and while many present-day genes in these lineages predate this divergence, the extent to which these genes still perform their ancestral functions is largely unknown. To test principles governing retention of ancient function, we asked if prokaryotic genes could replace their essential eukaryotic orthologs. We systematically replaced essential genes in yeast by their 1:1 orthologs from Escherichia coli. After accounting for mitochondrial localization and alternative start codons, 31 out of 51 bacterial genes tested (61%) could complement a lethal growth defect and replace their yeast orthologs with minimal effects on growth rate. Replaceability was determined on a pathway-by-pathway basis; codon usage, abundance, and sequence similarity contributed predictive power. The heme biosynthesis pathway was particularly amenable to inter-kingdom exchange, with each yeast enzyme replaceable by its bacterial, human, or plant ortholog, suggesting it as a near-universally swappable pathway." @default.
- W2733690549 created "2017-07-14" @default.
- W2733690549 creator A5007242541 @default.
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- W2733690549 date "2017-06-29" @default.
- W2733690549 modified "2023-10-15" @default.
- W2733690549 title "Systematic bacterialization of yeast genes identifies a near-universally swappable pathway" @default.
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- W2733690549 doi "https://doi.org/10.7554/elife.25093" @default.
- W2733690549 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5536947" @default.
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- W2733690549 hasPublicationYear "2017" @default.
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