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- W2734171975 abstract "We attempted to prepare sustained release fine particles using a two-step mechanical powder processing method; particle-shape modification and dry particle coating. First, particle shape of bulk drug was modified by mechanical treatment to yield drug crystals suitable for the coating process. Drug crystals became more rounded with increasing rotation speed, which demonstrates that powerful mechanical stress yields spherical drug crystals with narrow size distribution. This process is the result of destruction, granulation and refinement of drug crystals. Second, the modified drug particles and polymer coating powder were mechanically treated to prepare composite particles. Polymer nanoparticle agglomerate obtained by drying poly(meth)acrylate aqueous dispersion was used as a coating powder. The porous nanoparticle agglomerate has superior coating performance, because it is completely deagglomerated under mechanical stress to form fine fragments that act as guest particles. As a result, spherical drug crystals treated with porous agglomerate were effectively coated by polymeric powder, showing sustained release after curing process. From these findings, particle-shape modification of drug crystals and dry particle coating with nanoparticle agglomerate using a mechanical powder processor is expected as an innovative non-aqueous technique for preparing controlled-release coated particles having high drug content and size smaller than 100 μm." @default.
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- W2734171975 date "2014-01-01" @default.
- W2734171975 modified "2023-10-16" @default.
- W2734171975 title "Development of Innovative Dry Coating Technique Using Ordered Mixing Approach" @default.
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- W2734171975 doi "https://doi.org/10.14356/hptf.12108" @default.
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