Matches in SemOpenAlex for { <https://semopenalex.org/work/W2734206710> ?p ?o ?g. }
- W2734206710 endingPage "81" @default.
- W2734206710 startingPage "81" @default.
- W2734206710 abstract "DNA double-strand breaks (DSBs) are deleterious DNA lesions that if left unrepaired or are misrepaired, potentially result in chromosomal aberrations, known drivers of carcinogenesis. Pathways that direct the repair of DSBs are traditionally believed to be guardians of the genome as they protect cells from genomic instability. The prominent DSB repair pathway in human cells is the non-homologous end joining (NHEJ) pathway, which mediates template-independent re-ligation of the broken DNA molecule and is active in all phases of the cell cycle. Its role as a guardian of the genome is supported by the fact that defects in NHEJ lead to increased sensitivity to agents that induce DSBs and an increased frequency of chromosomal aberrations. Conversely, evidence from tumors and tumor cell lines has emerged that NHEJ also promotes chromosomal aberrations and genomic instability, particularly in cells that have a defect in one of the other DSB repair pathways. Collectively, the data present a conundrum: how can a single pathway both suppress and promote carcinogenesis? In this review, we will examine NHEJ’s role as both a guardian and a disruptor of the genome and explain how underlying genetic context not only dictates whether NHEJ promotes or suppresses carcinogenesis, but also how it alters the response of tumors to conventional therapeutics." @default.
- W2734206710 created "2017-07-14" @default.
- W2734206710 creator A5002299243 @default.
- W2734206710 creator A5081758694 @default.
- W2734206710 date "2017-07-06" @default.
- W2734206710 modified "2023-10-10" @default.
- W2734206710 title "The Role of the Core Non-Homologous End Joining Factors in Carcinogenesis and Cancer" @default.
- W2734206710 cites W1483338778 @default.
- W2734206710 cites W1509713940 @default.
- W2734206710 cites W1529396499 @default.
- W2734206710 cites W1544000508 @default.
- W2734206710 cites W1552272991 @default.
- W2734206710 cites W1552661588 @default.
- W2734206710 cites W1556385426 @default.
- W2734206710 cites W1580104271 @default.
- W2734206710 cites W1600510649 @default.
- W2734206710 cites W1608755692 @default.
- W2734206710 cites W1620761868 @default.
- W2734206710 cites W1622118769 @default.
- W2734206710 cites W1637061912 @default.
- W2734206710 cites W1639880497 @default.
- W2734206710 cites W1767798659 @default.
- W2734206710 cites W1779829992 @default.
- W2734206710 cites W1818120421 @default.
- W2734206710 cites W1840835788 @default.
- W2734206710 cites W1841743894 @default.
- W2734206710 cites W1860020500 @default.
- W2734206710 cites W1883274293 @default.
- W2734206710 cites W1896698005 @default.
- W2734206710 cites W1929860445 @default.
- W2734206710 cites W196512513 @default.
- W2734206710 cites W1965439396 @default.
- W2734206710 cites W1967198911 @default.
- W2734206710 cites W1969235650 @default.
- W2734206710 cites W1969357866 @default.
- W2734206710 cites W1972044166 @default.
- W2734206710 cites W1972828814 @default.
- W2734206710 cites W1973051105 @default.
- W2734206710 cites W1975114208 @default.
- W2734206710 cites W1975155994 @default.
- W2734206710 cites W1977430779 @default.
- W2734206710 cites W1978282378 @default.
- W2734206710 cites W1979699797 @default.
- W2734206710 cites W1982362157 @default.
- W2734206710 cites W1982591822 @default.
- W2734206710 cites W1982945504 @default.
- W2734206710 cites W1984938004 @default.
- W2734206710 cites W1986320226 @default.
- W2734206710 cites W1986990473 @default.
- W2734206710 cites W1987850577 @default.
- W2734206710 cites W1988015509 @default.
- W2734206710 cites W1988225111 @default.
- W2734206710 cites W1988845313 @default.
- W2734206710 cites W1990039985 @default.
- W2734206710 cites W1991915678 @default.
- W2734206710 cites W1992272549 @default.
- W2734206710 cites W1992688638 @default.
- W2734206710 cites W1994813693 @default.
- W2734206710 cites W1995204735 @default.
- W2734206710 cites W1997355958 @default.
- W2734206710 cites W1998530321 @default.
- W2734206710 cites W1999105804 @default.
- W2734206710 cites W1999161678 @default.
- W2734206710 cites W2001134174 @default.
- W2734206710 cites W2003139749 @default.
- W2734206710 cites W2004360438 @default.
- W2734206710 cites W2004370917 @default.
- W2734206710 cites W2004735306 @default.
- W2734206710 cites W2005567329 @default.
- W2734206710 cites W2006552986 @default.
- W2734206710 cites W2006824325 @default.
- W2734206710 cites W2007894476 @default.
- W2734206710 cites W2008686043 @default.
- W2734206710 cites W2014589422 @default.
- W2734206710 cites W2016172704 @default.
- W2734206710 cites W2016507277 @default.
- W2734206710 cites W2018179845 @default.
- W2734206710 cites W2018609920 @default.
- W2734206710 cites W2020825769 @default.
- W2734206710 cites W2021314470 @default.
- W2734206710 cites W2022163673 @default.
- W2734206710 cites W2022495797 @default.
- W2734206710 cites W2024101825 @default.
- W2734206710 cites W2024254896 @default.
- W2734206710 cites W2025063605 @default.
- W2734206710 cites W2025652696 @default.
- W2734206710 cites W2026292458 @default.
- W2734206710 cites W2027370757 @default.
- W2734206710 cites W2027380102 @default.
- W2734206710 cites W2032828704 @default.
- W2734206710 cites W2033516186 @default.
- W2734206710 cites W2039284885 @default.
- W2734206710 cites W2039704215 @default.
- W2734206710 cites W2040847982 @default.
- W2734206710 cites W2041721546 @default.
- W2734206710 cites W2041868573 @default.
- W2734206710 cites W2043972688 @default.
- W2734206710 cites W2044680650 @default.