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• W2734377577 abstract "Significance T-follicular regulatory (Tfr) cells, a subset of Foxp3-expressing regulatory T (Treg) cells, have a critical role in the control of antibody responses. Whereas Treg cells express CD25 and are dependent on IL-2, Tfr cells also express the transcription factor BCL6 that is inhibited by IL-2 in T-follicular helper (Tfh) cells. In this report, we find that mature Tfr cells in the germinal centers or circulating in human blood down-regulate CD25 and gain a transcriptional signature mixed between Tfh cells and Treg cells while retaining their regulatory function. These cells represent an IL-2–independent branch of effector Treg cells losing CD25 expression but gaining increased expression of Tfh-related markers, such as BCL6 and CXCR5, in both mice and humans." @default.
• W2734377577 created "2017-07-21" @default.
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• W2734377577 date "2017-07-11" @default.
• W2734377577 modified "2023-10-18" @default.
• W2734377577 title "A distinct subpopulation of CD25 ⁻ T-follicular regulatory cells localizes in the germinal centers" @default.
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• W2734377577 doi "https://doi.org/10.1073/pnas.1705551114" @default.
• W2734377577 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5547636" @default.
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