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- W2734415063 abstract "This study had a twofold purpose. First, the usefulness of the simplex algorithm as a short method of optimization in high performance liquid chromatographic separations was investigated. The second was to test a modified simplex method. The volume fractions of mobile phase components were chosen as the variable factors in the optimization process. Four test cases were performed which included separation of cholesterol esters, naphthalene and its derivatives, polycyclic aromatic compounds, and the thiane compounds. The standard for accepting an optimum was based on the baseline separation of two adjacent peaks and the analysis time. In addition to successful separations, the correlation between the separation and the chemical characteristics of mobile phase compositions was calculated and this could then be used for further modification of simplex search strategy." @default.
- W2734415063 created "2017-07-21" @default.
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- W2734415063 date "1983-08-01" @default.
- W2734415063 modified "2023-09-24" @default.
- W2734415063 title "Optimization of High Performance Liquid Chromatographic Separations" @default.
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