FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2734437886> ?p ?o ?g. }

• W2734437886 endingPage "1436" @default.
• W2734437886 startingPage "1431" @default.
• W2734437886 abstract "Abstract Owing to their immunosuppressive properties, mesenchymal stromal cells (MSCs) obtained from bone marrow (BM-MSCs) or adipose tissue (ASCs) are considered a promising tool for cell therapy. However, important issues should be considered to ensure the reproducible production of efficient and safe clinical-grade MSCs. In particular, high expansion rate, associated with progressive senescence, was recently proposed as one of the parameters that could alter MSC functionality. In this study, we directly address the consequences of replicative senescence on BM-MSC and ASC immunomodulatory properties. We demonstrate that MSCs produced according to GMP procedures inhibit less efficiently T-cell, but not Natural Killer (NK)- and B-cell, proliferation after reaching senescence. Senescence-related loss-of-function is associated with a decreased indoleamine 2,3-dioxygenase (IDO) activity in response to inflammatory stimuli. In particular, although STAT-1-dependent IDO expression is transcriptionally induced at a similar level in senescent and nonsenescent MSCs, IDO protein is specifically degraded by the proteasome in senescent ASCs and BM-MSCs, a process that could be reversed by the MG132 proteasome inhibitor. These data encourage the use of appropriate quality controls focusing on immunosuppressive mechanisms before translating clinical-grade MSCs in the clinic." @default.
• W2734437886 created "2017-07-21" @default.
• W2734437886 creator A5002930156 @default.
• W2734437886 creator A5003236857 @default.
• W2734437886 creator A5015128940 @default.
• W2734437886 creator A5015523345 @default.
• W2734437886 creator A5028088087 @default.
• W2734437886 creator A5035643340 @default.
• W2734437886 creator A5046135692 @default.
• W2734437886 creator A5058339316 @default.
• W2734437886 creator A5060943734 @default.
• W2734437886 creator A5063589954 @default.
• W2734437886 creator A5076729444 @default.
• W2734437886 creator A5080491423 @default.
• W2734437886 creator A5083920831 @default.
• W2734437886 date "2017-02-23" @default.
• W2734437886 modified "2023-10-18" @default.
• W2734437886 title "Brief Report: Proteasomal Indoleamine 2,3-Dioxygenase Degradation Reduces the Immunosuppressive Potential of Clinical Grade-Mesenchymal Stromal Cells Undergoing Replicative Senescence" @default.
• W2734437886 cites W1494511436 @default.
• W2734437886 cites W1530824105 @default.
• W2734437886 cites W1970780414 @default.
• W2734437886 cites W1977641825 @default.
• W2734437886 cites W1979043688 @default.
• W2734437886 cites W1979747571 @default.
• W2734437886 cites W1987348882 @default.
• W2734437886 cites W1992595068 @default.
• W2734437886 cites W2010343273 @default.
• W2734437886 cites W2019696829 @default.
• W2734437886 cites W2020073619 @default.
• W2734437886 cites W2022915249 @default.
• W2734437886 cites W2033675587 @default.
• W2734437886 cites W2045080708 @default.
• W2734437886 cites W2050875930 @default.
• W2734437886 cites W2058473775 @default.
• W2734437886 cites W2099429097 @default.
• W2734437886 cites W2102330961 @default.
• W2734437886 cites W2123051252 @default.
• W2734437886 cites W2147854121 @default.
• W2734437886 cites W2201248084 @default.
• W2734437886 cites W2221267861 @default.
• W2734437886 cites W2410980946 @default.
• W2734437886 doi "https://doi.org/10.1002/stem.2580" @default.
• W2734437886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28142215" @default.
• W2734437886 hasPublicationYear "2017" @default.
• W2734437886 type Work @default.
• W2734437886 sameAs 2734437886 @default.
• W2734437886 citedByCount "32" @default.
• W2734437886 countsByYear W27344378862017 @default.
• W2734437886 countsByYear W27344378862018 @default.
• W2734437886 countsByYear W27344378862019 @default.
• W2734437886 countsByYear W27344378862020 @default.
• W2734437886 countsByYear W27344378862021 @default.
• W2734437886 countsByYear W27344378862022 @default.
• W2734437886 countsByYear W27344378862023 @default.
• W2734437886 crossrefType "journal-article" @default.
• W2734437886 hasAuthorship W2734437886A5002930156 @default.
• W2734437886 hasAuthorship W2734437886A5003236857 @default.
• W2734437886 hasAuthorship W2734437886A5015128940 @default.
• W2734437886 hasAuthorship W2734437886A5015523345 @default.
• W2734437886 hasAuthorship W2734437886A5028088087 @default.
• W2734437886 hasAuthorship W2734437886A5035643340 @default.
• W2734437886 hasAuthorship W2734437886A5046135692 @default.
• W2734437886 hasAuthorship W2734437886A5058339316 @default.
• W2734437886 hasAuthorship W2734437886A5060943734 @default.
• W2734437886 hasAuthorship W2734437886A5063589954 @default.
• W2734437886 hasAuthorship W2734437886A5076729444 @default.
• W2734437886 hasAuthorship W2734437886A5080491423 @default.
• W2734437886 hasAuthorship W2734437886A5083920831 @default.
• W2734437886 hasBestOaLocation W27344378861 @default.
• W2734437886 hasConcept C1491633281 @default.
• W2734437886 hasConcept C16930146 @default.
• W2734437886 hasConcept C198826908 @default.
• W2734437886 hasConcept C203014093 @default.
• W2734437886 hasConcept C27740335 @default.
• W2734437886 hasConcept C2776706248 @default.
• W2734437886 hasConcept C2778367456 @default.
• W2734437886 hasConcept C2780007613 @default.
• W2734437886 hasConcept C502942594 @default.
• W2734437886 hasConcept C515207424 @default.
• W2734437886 hasConcept C522857546 @default.
• W2734437886 hasConcept C55493867 @default.
• W2734437886 hasConcept C83478079 @default.
• W2734437886 hasConcept C86803240 @default.
• W2734437886 hasConcept C8891405 @default.
• W2734437886 hasConcept C95444343 @default.
• W2734437886 hasConceptScore W2734437886C1491633281 @default.
• W2734437886 hasConceptScore W2734437886C16930146 @default.
• W2734437886 hasConceptScore W2734437886C198826908 @default.
• W2734437886 hasConceptScore W2734437886C203014093 @default.
• W2734437886 hasConceptScore W2734437886C27740335 @default.
• W2734437886 hasConceptScore W2734437886C2776706248 @default.
• W2734437886 hasConceptScore W2734437886C2778367456 @default.
• W2734437886 hasConceptScore W2734437886C2780007613 @default.
• W2734437886 hasConceptScore W2734437886C502942594 @default.
• W2734437886 hasConceptScore W2734437886C515207424 @default.
• W2734437886 hasConceptScore W2734437886C522857546 @default.
• W2734437886 hasConceptScore W2734437886C55493867 @default.
• W2734437886 hasConceptScore W2734437886C83478079 @default.

• next