FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2734465458> ?p ?o ?g. }

• W2734465458 endingPage "615" @default.
• W2734465458 startingPage "603" @default.
• W2734465458 abstract "Multiple sclerosis (MS) is a classical inflammatory demyelinating disease of the central nervous system (CNS). Microglia are the main resident immune cells in the CNS and are closely associated with the pathogenesis of MS. In the present study, we found that miR-30a was highly expressed in jellyfish-like microglia in chronic active lesions of MS patients, as well as in the microglia of mice with experimental autoimmune encephalomyelitis (EAE) at the chronic phase. In vitro, the conditioned supernatant of mouse microglia overexpressing miR-30a promoted the apoptosis of oligodendrocyte precursor cells (OPCs), and inhibited OPC differentiation. In vivo, overexpressing miR-30a in transplanted microglia exacerbated the progression of EAE. Overexpression and knock-down experiments in primary cultured mouse microglia showed that miR-30a increased the expression of IL-1β and iNOS, which are pro-inflammatory, while inhibiting the expression of Ym-1 and CD206. Mechanistically, miR-30a inhibited the expression of Ppargc1b, which is the co-activator of peroxisome proliferator-activated receptor gamma, resulting in pro-inflammatory effects. Our work shows that miR-30a is an important regulator of the inflammatory response in microglia, and may be a promising therapeutic target for inflammatory diseases like MS in the CNS." @default.
• W2734465458 created "2017-07-21" @default.
• W2734465458 creator A5008473333 @default.
• W2734465458 creator A5012635551 @default.
• W2734465458 creator A5013874680 @default.
• W2734465458 creator A5022306594 @default.
• W2734465458 creator A5032407482 @default.
• W2734465458 creator A5043956235 @default.
• W2734465458 creator A5048937704 @default.
• W2734465458 creator A5058380236 @default.
• W2734465458 creator A5067838476 @default.
• W2734465458 creator A5075922369 @default.
• W2734465458 creator A5090424198 @default.
• W2734465458 creator A5091386104 @default.
• W2734465458 date "2017-07-17" @default.
• W2734465458 modified "2023-09-25" @default.
• W2734465458 title "MiR-30a Positively Regulates the Inflammatory Response of Microglia in Experimental Autoimmune Encephalomyelitis" @default.
• W2734465458 cites W1817666133 @default.
• W2734465458 cites W1828576284 @default.
• W2734465458 cites W1915908724 @default.
• W2734465458 cites W1964158186 @default.
• W2734465458 cites W1969978989 @default.
• W2734465458 cites W1972752407 @default.
• W2734465458 cites W1973101671 @default.
• W2734465458 cites W1977213877 @default.
• W2734465458 cites W1978520932 @default.
• W2734465458 cites W1987700102 @default.
• W2734465458 cites W1995349006 @default.
• W2734465458 cites W2024140382 @default.
• W2734465458 cites W2032791246 @default.
• W2734465458 cites W2038689279 @default.
• W2734465458 cites W2042207589 @default.
• W2734465458 cites W2050091174 @default.
• W2734465458 cites W2055797258 @default.
• W2734465458 cites W2071611370 @default.
• W2734465458 cites W2077498638 @default.
• W2734465458 cites W2081810806 @default.
• W2734465458 cites W2085225921 @default.
• W2734465458 cites W2089122712 @default.
• W2734465458 cites W2095876795 @default.
• W2734465458 cites W2136266325 @default.
• W2734465458 cites W2145968349 @default.
• W2734465458 cites W2156023352 @default.
• W2734465458 cites W2162978315 @default.
• W2734465458 cites W2185633290 @default.
• W2734465458 cites W2221925756 @default.
• W2734465458 cites W2264197941 @default.
• W2734465458 cites W2301507011 @default.
• W2734465458 cites W2318370297 @default.
• W2734465458 cites W2467154812 @default.
• W2734465458 cites W2517742795 @default.
• W2734465458 doi "https://doi.org/10.1007/s12264-017-0153-y" @default.
• W2734465458 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5725374" @default.
• W2734465458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28717866" @default.
• W2734465458 hasPublicationYear "2017" @default.
• W2734465458 type Work @default.
• W2734465458 sameAs 2734465458 @default.
• W2734465458 citedByCount "28" @default.
• W2734465458 countsByYear W27344654582017 @default.
• W2734465458 countsByYear W27344654582018 @default.
• W2734465458 countsByYear W27344654582019 @default.
• W2734465458 countsByYear W27344654582020 @default.
• W2734465458 countsByYear W27344654582022 @default.
• W2734465458 countsByYear W27344654582023 @default.
• W2734465458 crossrefType "journal-article" @default.
• W2734465458 hasAuthorship W2734465458A5008473333 @default.
• W2734465458 hasAuthorship W2734465458A5012635551 @default.
• W2734465458 hasAuthorship W2734465458A5013874680 @default.
• W2734465458 hasAuthorship W2734465458A5022306594 @default.
• W2734465458 hasAuthorship W2734465458A5032407482 @default.
• W2734465458 hasAuthorship W2734465458A5043956235 @default.
• W2734465458 hasAuthorship W2734465458A5048937704 @default.
• W2734465458 hasAuthorship W2734465458A5058380236 @default.
• W2734465458 hasAuthorship W2734465458A5067838476 @default.
• W2734465458 hasAuthorship W2734465458A5075922369 @default.
• W2734465458 hasAuthorship W2734465458A5090424198 @default.
• W2734465458 hasAuthorship W2734465458A5091386104 @default.
• W2734465458 hasBestOaLocation W27344654582 @default.
• W2734465458 hasConcept C203014093 @default.
• W2734465458 hasConcept C2776914184 @default.
• W2734465458 hasConcept C2777899865 @default.
• W2734465458 hasConcept C2778486448 @default.
• W2734465458 hasConcept C2779830541 @default.
• W2734465458 hasConcept C2780640218 @default.
• W2734465458 hasConcept C71924100 @default.
• W2734465458 hasConcept C86803240 @default.
• W2734465458 hasConcept C87753298 @default.
• W2734465458 hasConcept C8891405 @default.
• W2734465458 hasConceptScore W2734465458C203014093 @default.
• W2734465458 hasConceptScore W2734465458C2776914184 @default.
• W2734465458 hasConceptScore W2734465458C2777899865 @default.
• W2734465458 hasConceptScore W2734465458C2778486448 @default.
• W2734465458 hasConceptScore W2734465458C2779830541 @default.
• W2734465458 hasConceptScore W2734465458C2780640218 @default.
• W2734465458 hasConceptScore W2734465458C71924100 @default.
• W2734465458 hasConceptScore W2734465458C86803240 @default.
• W2734465458 hasConceptScore W2734465458C87753298 @default.
• W2734465458 hasConceptScore W2734465458C8891405 @default.

• next