FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2734467035> ?p ?o ?g. }

• W2734467035 endingPage "546" @default.
• W2734467035 startingPage "533" @default.
• W2734467035 abstract "Three-dimensional visualization of the brain vasculature and its interactions with surrounding cells may shed light on diseases where aberrant microvascular organization is involved, including glioblastoma (GBM). Intravital confocal imaging allows 3D visualization of microvascular structures and migration of cells in the brain of mice, however, with limited imaging depth. To enable comprehensive analysis of GBM and the brain microenvironment, in-depth 3D imaging methods are needed. Here, we employed methods for optical tissue clearing prior to 3D microscopy to visualize the brain microvasculature and routes of invasion of GBM cells.We present a workflow for ex vivo imaging of optically cleared brain tumor tissues and subsequent computational modeling. This workflow was used for quantification of the microvasculature in relation to nuclear or cellular density in healthy mouse brain tissues and in human orthotopic, infiltrative GBM8 and E98 glioblastoma models.Ex vivo cleared mouse brain tissues had a >10-fold imaging depth as compared to intravital imaging of mouse brain in vivo. Imaging of optically cleared brain tissue allowed quantification of the 3D microvascular characteristics in healthy mouse brains and in tissues with diffuse, infiltrative growing GBM8 brain tumors. Detailed 3D visualization revealed the organization of tumor cells relative to the vasculature, in both gray matter and white matter regions, and patterns of multicellular GBM networks collectively invading the brain parenchyma.Optical tissue clearing opens new avenues for combined quantitative and 3D microscopic analysis of the topographical relationship between GBM cells and their microenvironment." @default.
• W2734467035 created "2017-07-21" @default.
• W2734467035 creator A5001774953 @default.
• W2734467035 creator A5004518590 @default.
• W2734467035 creator A5004632162 @default.
• W2734467035 creator A5009217310 @default.
• W2734467035 creator A5013242801 @default.
• W2734467035 creator A5018310989 @default.
• W2734467035 creator A5025047600 @default.
• W2734467035 creator A5029218493 @default.
• W2734467035 creator A5031807229 @default.
• W2734467035 creator A5035327682 @default.
• W2734467035 creator A5038405578 @default.
• W2734467035 creator A5050961926 @default.
• W2734467035 creator A5051927182 @default.
• W2734467035 creator A5053700204 @default.
• W2734467035 creator A5056188201 @default.
• W2734467035 creator A5072183451 @default.
• W2734467035 date "2017-07-11" @default.
• W2734467035 modified "2023-09-24" @default.
• W2734467035 title "Optical clearing and fluorescence deep-tissue imaging for 3D quantitative analysis of the brain tumor microenvironment" @default.
• W2734467035 cites W1500871407 @default.
• W2734467035 cites W1522977578 @default.
• W2734467035 cites W1773887946 @default.
• W2734467035 cites W1921862095 @default.
• W2734467035 cites W194845536 @default.
• W2734467035 cites W1966687379 @default.
• W2734467035 cites W1967574983 @default.
• W2734467035 cites W1976096075 @default.
• W2734467035 cites W1984692724 @default.
• W2734467035 cites W1986586948 @default.
• W2734467035 cites W1986845743 @default.
• W2734467035 cites W1989396876 @default.
• W2734467035 cites W2005286422 @default.
• W2734467035 cites W2010114799 @default.
• W2734467035 cites W2010956007 @default.
• W2734467035 cites W2011650974 @default.
• W2734467035 cites W2012013780 @default.
• W2734467035 cites W2017523094 @default.
• W2734467035 cites W2023639738 @default.
• W2734467035 cites W2036239622 @default.
• W2734467035 cites W2037947871 @default.
• W2734467035 cites W2051036306 @default.
• W2734467035 cites W2052003865 @default.
• W2734467035 cites W2068391384 @default.
• W2734467035 cites W2068698274 @default.
• W2734467035 cites W2070713204 @default.
• W2734467035 cites W2075165836 @default.
• W2734467035 cites W2076507262 @default.
• W2734467035 cites W2078677652 @default.
• W2734467035 cites W2083048982 @default.
• W2734467035 cites W2089798586 @default.
• W2734467035 cites W2099071878 @default.
• W2734467035 cites W2105239575 @default.
• W2734467035 cites W2113282518 @default.
• W2734467035 cites W2117441339 @default.
• W2734467035 cites W2128130529 @default.
• W2734467035 cites W2136537123 @default.
• W2734467035 cites W2143308874 @default.
• W2734467035 cites W2143468862 @default.
• W2734467035 cites W2147607085 @default.
• W2734467035 cites W2149797529 @default.
• W2734467035 cites W2166572577 @default.
• W2734467035 cites W2256402448 @default.
• W2734467035 cites W2297210820 @default.
• W2734467035 cites W2341868515 @default.
• W2734467035 cites W2408110716 @default.
• W2734467035 cites W2512571444 @default.
• W2734467035 cites W2512833897 @default.
• W2734467035 cites W2886257723 @default.
• W2734467035 cites W3103749967 @default.
• W2734467035 doi "https://doi.org/10.1007/s10456-017-9565-6" @default.
• W2734467035 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5660146" @default.
• W2734467035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28699046" @default.
• W2734467035 hasPublicationYear "2017" @default.
• W2734467035 type Work @default.
• W2734467035 sameAs 2734467035 @default.
• W2734467035 citedByCount "63" @default.
• W2734467035 countsByYear W27344670352018 @default.
• W2734467035 countsByYear W27344670352019 @default.
• W2734467035 countsByYear W27344670352020 @default.
• W2734467035 countsByYear W27344670352021 @default.
• W2734467035 countsByYear W27344670352022 @default.
• W2734467035 countsByYear W27344670352023 @default.
• W2734467035 crossrefType "journal-article" @default.
• W2734467035 hasAuthorship W2734467035A5001774953 @default.
• W2734467035 hasAuthorship W2734467035A5004518590 @default.
• W2734467035 hasAuthorship W2734467035A5004632162 @default.
• W2734467035 hasAuthorship W2734467035A5009217310 @default.
• W2734467035 hasAuthorship W2734467035A5013242801 @default.
• W2734467035 hasAuthorship W2734467035A5018310989 @default.
• W2734467035 hasAuthorship W2734467035A5025047600 @default.
• W2734467035 hasAuthorship W2734467035A5029218493 @default.
• W2734467035 hasAuthorship W2734467035A5031807229 @default.
• W2734467035 hasAuthorship W2734467035A5035327682 @default.
• W2734467035 hasAuthorship W2734467035A5038405578 @default.
• W2734467035 hasAuthorship W2734467035A5050961926 @default.
• W2734467035 hasAuthorship W2734467035A5051927182 @default.

• next