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- W2734471036 endingPage "10749" @default.
- W2734471036 startingPage "10742" @default.
- W2734471036 abstract "Although backbone hydrogen bonds in transmembrane (TM) helices have the potential to be very strong due to the low dielectric and low water environment of the membrane, their strength has never been assessed experimentally. Moreover, variations in hydrogen bond strength might be necessary to facilitate the TM helix breaking and bending that is often needed to satisfy functional imperatives. Here we employed equilibrium hydrogen/deuterium fractionation factors to measure backbone hydrogen bond strengths in the TM helix of the amyloid precursor protein (APP). We find an enormous range of hydrogen bond free energies, with some weaker than water–water hydrogen bonds and some over 6 kcal/mol stronger than water–water hydrogen bonds. We find that weak hydrogen bonds are at or near preferred γ-secretase cleavage sites, suggesting that the sequence of APP and possibly other cleaved TM helices may be designed, in part, to make their backbones accessible for cleavage. The finding that hydrogen bond strengths in a TM helix can vary widely has implications for membrane protein function, dynamics, evolution, and design." @default.
- W2734471036 created "2017-07-21" @default.
- W2734471036 creator A5007437458 @default.
- W2734471036 creator A5017304834 @default.
- W2734471036 creator A5017731648 @default.
- W2734471036 creator A5064806696 @default.
- W2734471036 date "2017-07-10" @default.
- W2734471036 modified "2023-10-14" @default.
- W2734471036 title "Backbone Hydrogen Bond Strengths Can Vary Widely in Transmembrane Helices" @default.
- W2734471036 cites W1499270645 @default.
- W2734471036 cites W1510774549 @default.
- W2734471036 cites W1536642293 @default.
- W2734471036 cites W1574665620 @default.
- W2734471036 cites W1812970642 @default.
- W2734471036 cites W1964305847 @default.
- W2734471036 cites W1964457995 @default.
- W2734471036 cites W1966215402 @default.
- W2734471036 cites W1967480194 @default.
- W2734471036 cites W1969787762 @default.
- W2734471036 cites W1977222497 @default.
- W2734471036 cites W1979534834 @default.
- W2734471036 cites W1979657417 @default.
- W2734471036 cites W1980825524 @default.
- W2734471036 cites W1981237912 @default.
- W2734471036 cites W1986892064 @default.
- W2734471036 cites W1987169321 @default.
- W2734471036 cites W1988326881 @default.
- W2734471036 cites W1988422603 @default.
- W2734471036 cites W1988791617 @default.
- W2734471036 cites W1988909765 @default.
- W2734471036 cites W1989190536 @default.
- W2734471036 cites W1990515637 @default.
- W2734471036 cites W1996297547 @default.
- W2734471036 cites W2001290027 @default.
- W2734471036 cites W2002584278 @default.
- W2734471036 cites W2007365285 @default.
- W2734471036 cites W2007415752 @default.
- W2734471036 cites W2008440654 @default.
- W2734471036 cites W2009973554 @default.
- W2734471036 cites W2010182484 @default.
- W2734471036 cites W2014982951 @default.
- W2734471036 cites W2015149444 @default.
- W2734471036 cites W2015381530 @default.
- W2734471036 cites W2016660067 @default.
- W2734471036 cites W2022796341 @default.
- W2734471036 cites W2023561215 @default.
- W2734471036 cites W2024211926 @default.
- W2734471036 cites W2025925640 @default.
- W2734471036 cites W2026432301 @default.
- W2734471036 cites W2031644342 @default.
- W2734471036 cites W2031710829 @default.
- W2734471036 cites W2033077848 @default.
- W2734471036 cites W2036917676 @default.
- W2734471036 cites W2041256732 @default.
- W2734471036 cites W2047562837 @default.
- W2734471036 cites W2047575592 @default.
- W2734471036 cites W2050586736 @default.
- W2734471036 cites W2052380879 @default.
- W2734471036 cites W2053271137 @default.
- W2734471036 cites W2053430992 @default.
- W2734471036 cites W2062016903 @default.
- W2734471036 cites W2062165317 @default.
- W2734471036 cites W2066958493 @default.
- W2734471036 cites W2070091907 @default.
- W2734471036 cites W2070732379 @default.
- W2734471036 cites W2074889347 @default.
- W2734471036 cites W2077421343 @default.
- W2734471036 cites W2080656986 @default.
- W2734471036 cites W2082429191 @default.
- W2734471036 cites W2082460632 @default.
- W2734471036 cites W2083768931 @default.
- W2734471036 cites W2084558544 @default.
- W2734471036 cites W2085095736 @default.
- W2734471036 cites W2088294097 @default.
- W2734471036 cites W2092002806 @default.
- W2734471036 cites W2092508662 @default.
- W2734471036 cites W2093948474 @default.
- W2734471036 cites W2094113671 @default.
- W2734471036 cites W2095375670 @default.
- W2734471036 cites W2096410114 @default.
- W2734471036 cites W2107005517 @default.
- W2734471036 cites W2107239101 @default.
- W2734471036 cites W2112967619 @default.
- W2734471036 cites W2119168667 @default.
- W2734471036 cites W2120396539 @default.
- W2734471036 cites W2121372252 @default.
- W2734471036 cites W2127395373 @default.
- W2734471036 cites W2137945247 @default.
- W2734471036 cites W2142944599 @default.
- W2734471036 cites W2143015200 @default.
- W2734471036 cites W2146107145 @default.
- W2734471036 cites W2146585035 @default.
- W2734471036 cites W2147491346 @default.
- W2734471036 cites W2153181859 @default.
- W2734471036 cites W2155149840 @default.
- W2734471036 cites W2156542857 @default.
- W2734471036 cites W2168416013 @default.
- W2734471036 cites W2323386724 @default.