Matches in SemOpenAlex for { <https://semopenalex.org/work/W2734494411> ?p ?o ?g. }
- W2734494411 endingPage "2293" @default.
- W2734494411 startingPage "2283" @default.
- W2734494411 abstract "A primary function of 5' regions in many secretory protein mRNAs is to encode an endoplasmic reticulum (ER) targeting sequence. In this study, we show how the regions coding for the ER-targeting sequences of the influenza glycoproteins NA and HA also function as translational regulatory elements that are controlled by the viral RNA-binding protein (RBP) NS1. The translational increase depends on the nucleotide composition and 5' positioning of the ER-targeting sequence coding regions and is facilitated by the RNA-binding domain of NS1, which can associate with ER membranes. Inserting the ER-targeting sequence coding region of NA into different 5' UTRs confirmed that NS1 can promote the translation of secretory protein mRNAs based on the nucleotides within this region rather than the resulting amino acids. By analyzing human protein mRNA sequences, we found evidence that this mechanism of using 5' coding regions and particular RBPs to achieve gene-specific regulation may extend to human-secreted proteins." @default.
- W2734494411 created "2017-07-21" @default.
- W2734494411 creator A5021972146 @default.
- W2734494411 creator A5054212634 @default.
- W2734494411 creator A5062034230 @default.
- W2734494411 creator A5063745992 @default.
- W2734494411 creator A5087056018 @default.
- W2734494411 creator A5087209692 @default.
- W2734494411 creator A5089299598 @default.
- W2734494411 date "2017-07-10" @default.
- W2734494411 modified "2023-10-18" @default.
- W2734494411 title "Translational regulation of viral secretory proteins by the 5′ coding regions and a viral RNA-binding protein" @default.
- W2734494411 cites W1538177878 @default.
- W2734494411 cites W1571866243 @default.
- W2734494411 cites W1588843730 @default.
- W2734494411 cites W1629488237 @default.
- W2734494411 cites W1695062097 @default.
- W2734494411 cites W1826483440 @default.
- W2734494411 cites W1986270104 @default.
- W2734494411 cites W1991467177 @default.
- W2734494411 cites W1996478334 @default.
- W2734494411 cites W1997535872 @default.
- W2734494411 cites W1997757456 @default.
- W2734494411 cites W2000451599 @default.
- W2734494411 cites W2004526658 @default.
- W2734494411 cites W2008410413 @default.
- W2734494411 cites W2038325264 @default.
- W2734494411 cites W2038598202 @default.
- W2734494411 cites W2041882488 @default.
- W2734494411 cites W2048157776 @default.
- W2734494411 cites W2048417421 @default.
- W2734494411 cites W2048998931 @default.
- W2734494411 cites W2056732680 @default.
- W2734494411 cites W2067341120 @default.
- W2734494411 cites W2070104333 @default.
- W2734494411 cites W2072549345 @default.
- W2734494411 cites W2079114119 @default.
- W2734494411 cites W2091527885 @default.
- W2734494411 cites W2099533162 @default.
- W2734494411 cites W2099763917 @default.
- W2734494411 cites W2102606027 @default.
- W2734494411 cites W2105694586 @default.
- W2734494411 cites W2106483921 @default.
- W2734494411 cites W2108708484 @default.
- W2734494411 cites W2109068727 @default.
- W2734494411 cites W2110214166 @default.
- W2734494411 cites W2111102789 @default.
- W2734494411 cites W2111366580 @default.
- W2734494411 cites W2112901090 @default.
- W2734494411 cites W2115110586 @default.
- W2734494411 cites W2120267577 @default.
- W2734494411 cites W2128207929 @default.
- W2734494411 cites W2130312623 @default.
- W2734494411 cites W2132233942 @default.
- W2734494411 cites W2137677335 @default.
- W2734494411 cites W2142282262 @default.
- W2734494411 cites W2146923243 @default.
- W2734494411 cites W2152542101 @default.
- W2734494411 cites W2157377535 @default.
- W2734494411 cites W2161746138 @default.
- W2734494411 cites W2242410361 @default.
- W2734494411 cites W2408181412 @default.
- W2734494411 cites W2442115625 @default.
- W2734494411 cites W4238660125 @default.
- W2734494411 doi "https://doi.org/10.1083/jcb.201702102" @default.
- W2734494411 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5551715" @default.
- W2734494411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28696227" @default.
- W2734494411 hasPublicationYear "2017" @default.
- W2734494411 type Work @default.
- W2734494411 sameAs 2734494411 @default.
- W2734494411 citedByCount "20" @default.
- W2734494411 countsByYear W27344944112017 @default.
- W2734494411 countsByYear W27344944112018 @default.
- W2734494411 countsByYear W27344944112019 @default.
- W2734494411 countsByYear W27344944112020 @default.
- W2734494411 countsByYear W27344944112021 @default.
- W2734494411 countsByYear W27344944112022 @default.
- W2734494411 countsByYear W27344944112023 @default.
- W2734494411 crossrefType "journal-article" @default.
- W2734494411 hasAuthorship W2734494411A5021972146 @default.
- W2734494411 hasAuthorship W2734494411A5054212634 @default.
- W2734494411 hasAuthorship W2734494411A5062034230 @default.
- W2734494411 hasAuthorship W2734494411A5063745992 @default.
- W2734494411 hasAuthorship W2734494411A5087056018 @default.
- W2734494411 hasAuthorship W2734494411A5087209692 @default.
- W2734494411 hasAuthorship W2734494411A5089299598 @default.
- W2734494411 hasBestOaLocation W27344944111 @default.
- W2734494411 hasConcept C104317684 @default.
- W2734494411 hasConcept C105580179 @default.
- W2734494411 hasConcept C149364088 @default.
- W2734494411 hasConcept C156399914 @default.
- W2734494411 hasConcept C158617107 @default.
- W2734494411 hasConcept C41282012 @default.
- W2734494411 hasConcept C54355233 @default.
- W2734494411 hasConcept C67705224 @default.
- W2734494411 hasConcept C86803240 @default.
- W2734494411 hasConcept C91779695 @default.
- W2734494411 hasConcept C95444343 @default.