FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2734494492> ?p ?o ?g. }

• W2734494492 endingPage "97" @default.
• W2734494492 startingPage "87" @default.
• W2734494492 abstract "The activity of natural killer (NK) cells is tightly regulated by inhibitory and activating receptors. Inhibitory killer immunoglobulin-like receptors (iKIRs) survey the surface of target cells by monitoring the expression of human leukocyte antigen (HLA) class I. The binding of iKIRs has been shown to be sensitive to the peptides presented by HLA class I, implying that iKIRs have the ability to detect the changes in the repertoire of peptide-HLA class I complexes (pHLA), a process occurring during viral infection and in tumor cells. To study how the pHLA repertoire changes upon infection, and whether an iKIR is able to detect these changes, we study peptides eluted from cells prior and after infection with measles virus (MV). Remarkably, most changes in the repertoire of potential iKIR ligands are predicted to be caused by the altered expression of self-peptides. We show that an iKIR can detect these changes in the presented peptides only if it is sufficiently specific, e.g., if iKIRs can distinguish between different amino acids in the contact residues (e.g., position 7 and 8). Our analysis further indicates that one single iKIR per host is not sufficient to detect changes in the peptide repertoire, suggesting that a multigene family encoding for different iKIRs is required for successful peptide recognition." @default.
• W2734494492 created "2017-07-21" @default.
• W2734494492 creator A5031710867 @default.
• W2734494492 creator A5053694044 @default.
• W2734494492 creator A5073950969 @default.
• W2734494492 date "2017-07-10" @default.
• W2734494492 modified "2023-10-12" @default.
• W2734494492 title "Specificity of inhibitory KIRs enables NK cells to detect changes in an altered peptide environment" @default.
• W2734494492 cites W1551056911 @default.
• W2734494492 cites W1905260826 @default.
• W2734494492 cites W1910621484 @default.
• W2734494492 cites W1911209830 @default.
• W2734494492 cites W1933245690 @default.
• W2734494492 cites W1942435386 @default.
• W2734494492 cites W1974308995 @default.
• W2734494492 cites W1992449083 @default.
• W2734494492 cites W1993071851 @default.
• W2734494492 cites W1993116214 @default.
• W2734494492 cites W1995765989 @default.
• W2734494492 cites W1997714286 @default.
• W2734494492 cites W2005710921 @default.
• W2734494492 cites W2037154691 @default.
• W2734494492 cites W2040133121 @default.
• W2734494492 cites W2053781768 @default.
• W2734494492 cites W2055771235 @default.
• W2734494492 cites W2066269914 @default.
• W2734494492 cites W2073261668 @default.
• W2734494492 cites W2073300038 @default.
• W2734494492 cites W2082515849 @default.
• W2734494492 cites W2087580642 @default.
• W2734494492 cites W2110036277 @default.
• W2734494492 cites W2135585879 @default.
• W2734494492 cites W2135778618 @default.
• W2734494492 cites W2136542540 @default.
• W2734494492 cites W2142489038 @default.
• W2734494492 cites W2147628746 @default.
• W2734494492 cites W2162962689 @default.
• W2734494492 cites W2164795954 @default.
• W2734494492 cites W2167339434 @default.
• W2734494492 cites W2171709048 @default.
• W2734494492 cites W2172005924 @default.
• W2734494492 cites W2176480377 @default.
• W2734494492 cites W2326870000 @default.
• W2734494492 cites W2519465234 @default.
• W2734494492 cites W4229953638 @default.
• W2734494492 cites W94644913 @default.
• W2734494492 doi "https://doi.org/10.1007/s00251-017-1019-1" @default.
• W2734494492 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5775373" @default.
• W2734494492 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28695292" @default.
• W2734494492 hasPublicationYear "2017" @default.
• W2734494492 type Work @default.
• W2734494492 sameAs 2734494492 @default.
• W2734494492 citedByCount "5" @default.
• W2734494492 countsByYear W27344944922019 @default.
• W2734494492 countsByYear W27344944922020 @default.
• W2734494492 countsByYear W27344944922022 @default.
• W2734494492 countsByYear W27344944922023 @default.
• W2734494492 crossrefType "journal-article" @default.
• W2734494492 hasAuthorship W2734494492A5031710867 @default.
• W2734494492 hasAuthorship W2734494492A5053694044 @default.
• W2734494492 hasAuthorship W2734494492A5073950969 @default.
• W2734494492 hasBestOaLocation W27344944921 @default.
• W2734494492 hasConcept C104317684 @default.
• W2734494492 hasConcept C121332964 @default.
• W2734494492 hasConcept C147483822 @default.
• W2734494492 hasConcept C167625842 @default.
• W2734494492 hasConcept C169760540 @default.
• W2734494492 hasConcept C170493617 @default.
• W2734494492 hasConcept C17077164 @default.
• W2734494492 hasConcept C188280979 @default.
• W2734494492 hasConcept C203014093 @default.
• W2734494492 hasConcept C24890656 @default.
• W2734494492 hasConcept C2778473898 @default.
• W2734494492 hasConcept C2779281246 @default.
• W2734494492 hasConcept C55493867 @default.
• W2734494492 hasConcept C86803240 @default.
• W2734494492 hasConcept C8891405 @default.
• W2734494492 hasConcept C95444343 @default.
• W2734494492 hasConceptScore W2734494492C104317684 @default.
• W2734494492 hasConceptScore W2734494492C121332964 @default.
• W2734494492 hasConceptScore W2734494492C147483822 @default.
• W2734494492 hasConceptScore W2734494492C167625842 @default.
• W2734494492 hasConceptScore W2734494492C169760540 @default.
• W2734494492 hasConceptScore W2734494492C170493617 @default.
• W2734494492 hasConceptScore W2734494492C17077164 @default.
• W2734494492 hasConceptScore W2734494492C188280979 @default.
• W2734494492 hasConceptScore W2734494492C203014093 @default.
• W2734494492 hasConceptScore W2734494492C24890656 @default.
• W2734494492 hasConceptScore W2734494492C2778473898 @default.
• W2734494492 hasConceptScore W2734494492C2779281246 @default.
• W2734494492 hasConceptScore W2734494492C55493867 @default.
• W2734494492 hasConceptScore W2734494492C86803240 @default.
• W2734494492 hasConceptScore W2734494492C8891405 @default.
• W2734494492 hasConceptScore W2734494492C95444343 @default.
• W2734494492 hasIssue "2" @default.
• W2734494492 hasLocation W27344944921 @default.
• W2734494492 hasLocation W27344944922 @default.
• W2734494492 hasLocation W27344944923 @default.

• next