FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2734499107> ?p ?o ?g. }

• W2734499107 abstract "Abstract The identification and tracking of antigen-specific immunoglobulin (Ig) sequences within total Ig repertoires is central to high-throughput sequencing (HTS) studies of infections or vaccinations. In this context, public Ig sequences shared by different individuals exposed to the same antigen could be valuable markers for tracing back infections, measuring vaccine immunogenicity, and perhaps ultimately allow the reconstruction of the immunological history of an individual. Here, we immunized groups of transgenic rats expressing human Ig against tetanus toxoid (TT), Modified Vaccinia virus Ankara (MVA), measles virus hemagglutinin and fusion proteins expressed on MVA and the environmental carcinogen Benzo[a]Pyrene, coupled to TT. We showed that these antigens impose a selective pressure causing the Ig Heavy chain (IgH) repertoires of the rats to converge towards the expression of antibodies with highly similar IgH CDR3 amino acid sequences. We present a computational approach, similar to differential gene expression analysis, that selects for clusters of CDR3s with 80% similarity, significantly overrepresented within the different groups of immunized rats. These IgH clusters represent antigen-induced IgH signatures exhibiting stereotypic amino acid patterns including previously described TT and measles specific IgH sequences. Our data suggest, that with the presented methodology, transgenic Ig rats can be utilized as a model to identify antigen-induced, human IgH signatures to a variety of different antigens." @default.
• W2734499107 created "2017-07-21" @default.
• W2734499107 creator A5005264549 @default.
• W2734499107 creator A5009591827 @default.
• W2734499107 creator A5024529211 @default.
• W2734499107 creator A5060033844 @default.
• W2734499107 creator A5061652215 @default.
• W2734499107 creator A5079422418 @default.
• W2734499107 creator A5084914497 @default.
• W2734499107 creator A5089782391 @default.
• W2734499107 date "2017-07-13" @default.
• W2734499107 modified "2023-09-25" @default.
• W2734499107 title "Functionally Convergent B Cell Receptor Sequences in Transgenic Rats Expressing a Human B Cell Repertoire in Response to Tetanus Toxoid and Measles Antigens" @default.
• W2734499107 cites W135571511 @default.
• W2734499107 cites W1511659675 @default.
• W2734499107 cites W1545131818 @default.
• W2734499107 cites W1550723234 @default.
• W2734499107 cites W1985767121 @default.
• W2734499107 cites W2001748695 @default.
• W2734499107 cites W2005310807 @default.
• W2734499107 cites W2018339091 @default.
• W2734499107 cites W2027515257 @default.
• W2734499107 cites W2029525307 @default.
• W2734499107 cites W2038873256 @default.
• W2734499107 cites W2045266215 @default.
• W2734499107 cites W2049631297 @default.
• W2734499107 cites W2051241958 @default.
• W2734499107 cites W2051298245 @default.
• W2734499107 cites W2056834190 @default.
• W2734499107 cites W2064468103 @default.
• W2734499107 cites W2071200955 @default.
• W2734499107 cites W2087008771 @default.
• W2734499107 cites W2091477384 @default.
• W2734499107 cites W2091670726 @default.
• W2734499107 cites W2095673187 @default.
• W2734499107 cites W2097816699 @default.
• W2734499107 cites W2100749074 @default.
• W2734499107 cites W2101387820 @default.
• W2734499107 cites W2105806118 @default.
• W2734499107 cites W2110065044 @default.
• W2734499107 cites W2116563764 @default.
• W2734499107 cites W2137489521 @default.
• W2734499107 cites W2138802086 @default.
• W2734499107 cites W2160578795 @default.
• W2734499107 cites W2165402419 @default.
• W2734499107 cites W2179438025 @default.
• W2734499107 cites W2224121944 @default.
• W2734499107 cites W2394816785 @default.
• W2734499107 cites W2434999576 @default.
• W2734499107 cites W2437001974 @default.
• W2734499107 cites W2492693765 @default.
• W2734499107 cites W2616207459 @default.
• W2734499107 cites W4233338164 @default.
• W2734499107 cites W4251633039 @default.
• W2734499107 cites W1974596630 @default.
• W2734499107 doi "https://doi.org/10.1101/159368" @default.
• W2734499107 hasPublicationYear "2017" @default.
• W2734499107 type Work @default.
• W2734499107 sameAs 2734499107 @default.
• W2734499107 citedByCount "1" @default.
• W2734499107 countsByYear W27344991072017 @default.
• W2734499107 crossrefType "posted-content" @default.
• W2734499107 hasAuthorship W2734499107A5005264549 @default.
• W2734499107 hasAuthorship W2734499107A5009591827 @default.
• W2734499107 hasAuthorship W2734499107A5024529211 @default.
• W2734499107 hasAuthorship W2734499107A5060033844 @default.
• W2734499107 hasAuthorship W2734499107A5061652215 @default.
• W2734499107 hasAuthorship W2734499107A5079422418 @default.
• W2734499107 hasAuthorship W2734499107A5084914497 @default.
• W2734499107 hasAuthorship W2734499107A5089782391 @default.
• W2734499107 hasBestOaLocation W27344991071 @default.
• W2734499107 hasConcept C147483822 @default.
• W2734499107 hasConcept C153911025 @default.
• W2734499107 hasConcept C159047783 @default.
• W2734499107 hasConcept C159654299 @default.
• W2734499107 hasConcept C195616568 @default.
• W2734499107 hasConcept C22070199 @default.
• W2734499107 hasConcept C2776438120 @default.
• W2734499107 hasConcept C2777351567 @default.
• W2734499107 hasConcept C2778199166 @default.
• W2734499107 hasConcept C2780801004 @default.
• W2734499107 hasConcept C2780868878 @default.
• W2734499107 hasConcept C54355233 @default.
• W2734499107 hasConcept C86803240 @default.
• W2734499107 hasConceptScore W2734499107C147483822 @default.
• W2734499107 hasConceptScore W2734499107C153911025 @default.
• W2734499107 hasConceptScore W2734499107C159047783 @default.
• W2734499107 hasConceptScore W2734499107C159654299 @default.
• W2734499107 hasConceptScore W2734499107C195616568 @default.
• W2734499107 hasConceptScore W2734499107C22070199 @default.
• W2734499107 hasConceptScore W2734499107C2776438120 @default.
• W2734499107 hasConceptScore W2734499107C2777351567 @default.
• W2734499107 hasConceptScore W2734499107C2778199166 @default.
• W2734499107 hasConceptScore W2734499107C2780801004 @default.
• W2734499107 hasConceptScore W2734499107C2780868878 @default.
• W2734499107 hasConceptScore W2734499107C54355233 @default.
• W2734499107 hasConceptScore W2734499107C86803240 @default.
• W2734499107 hasLocation W27344991071 @default.
• W2734499107 hasLocation W27344991072 @default.
• W2734499107 hasLocation W27344991073 @default.

• next