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- W2734538429 abstract "Aim: Study was designed to develop ultra-fast liquid chromatography method of antitubercular compound S006–830 in rat intestinal perfusate and apply method for determination of effective permeability coefficient (P eff ), absorption rate (K a ) and role of P-glycoprotein (P-gp) in the absorption. Methods: Chromatography was performed. P eff , K a of S006–830, role of P-gp in the absorption of S006–830 were determined by single-pass intestinal perfusion studies. Results: Method was found sensitive, reproducible. Recoveries of S006–830 were found around 60%. Method was applied for determination of P eff and K a . P eff and K a values indicated that S006–830 possesses high permeability and high absorption rate. Conclusion: Co-infusion of S006–830 with verapamil in single pass intestinal perfusion study demonstrated that P-gp do not have any significant role in the absorption of S006–830." @default.
- W2734538429 created "2017-07-21" @default.
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- W2734538429 date "2017-07-01" @default.
- W2734538429 modified "2023-09-25" @default.
- W2734538429 title "Intestinal permeability and role of P-glycoprotein in intestinal absorption of novel triethylamine containing thiophene S006–830 using single-pass intestinal perfusion in rats" @default.
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- W2734538429 doi "https://doi.org/10.4155/ipk-2017-0003" @default.
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