FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2734584105> ?p ?o ?g. }

• W2734584105 abstract "Abstract Intestinal tuft cells are one of 4 secretory cell linages in the small intestine and the source of IL-25, a critical initiator of the type 2 immune response to parasite infection. When Raptor, a critical scaffold protein for mammalian target of rapamycin complex 1 (mTORC1), was acutely deleted in intestinal epithelium via Tamoxifen injection in Tritrichomonas muris (Tm) infected mice, tuft cells, IL-25 in epithelium and IL-13 in the mesenchyme were significantly reduced, but Tm burden was not affected. When Tm infected mice were treated with rapamycin, DCLK1 and IL-25 expression in enterocytes and IL-13 expression in mesenchyme were diminished. After massive small bowel resection, tuft cells and Tm were diminished due to the diet used postoperatively. The elimination of Tm and subsequent re-infection of mice with Tm led to type 2 immune response only in WT, but Tm colonization in both WT and Raptor deficient mice. When intestinal organoids were stimulated with IL-4, tuft cells and IL-25 were induced in both WT and Raptor deficient organoids. In summary, our study reveals that enterocyte specific Raptor is required for initiating a type 2 immune response which appears to function through the regulation of mTORC1 activity." @default.
• W2734584105 created "2017-07-21" @default.
• W2734584105 creator A5002845612 @default.
• W2734584105 creator A5009941957 @default.
• W2734584105 creator A5035823766 @default.
• W2734584105 creator A5073997035 @default.
• W2734584105 creator A5081628715 @default.
• W2734584105 creator A5087049877 @default.
• W2734584105 creator A5089856110 @default.
• W2734584105 date "2017-07-17" @default.
• W2734584105 modified "2023-09-26" @default.
• W2734584105 title "Epithelial cell specific Raptor is required for initiation of type 2 mucosal immunity in small intestine" @default.
• W2734584105 cites W1519585418 @default.
• W2734584105 cites W1582276041 @default.
• W2734584105 cites W1783706650 @default.
• W2734584105 cites W1797689943 @default.
• W2734584105 cites W1996426153 @default.
• W2734584105 cites W2014911043 @default.
• W2734584105 cites W2019870550 @default.
• W2734584105 cites W2032445528 @default.
• W2734584105 cites W2049300468 @default.
• W2734584105 cites W2050306701 @default.
• W2734584105 cites W2076832266 @default.
• W2734584105 cites W2143112776 @default.
• W2734584105 cites W2146415848 @default.
• W2734584105 cites W2157584041 @default.
• W2734584105 cites W2164917731 @default.
• W2734584105 cites W2191813810 @default.
• W2734584105 cites W2195629512 @default.
• W2734584105 cites W2210729715 @default.
• W2734584105 cites W2233158352 @default.
• W2734584105 cites W2278768857 @default.
• W2734584105 cites W2294588583 @default.
• W2734584105 cites W2301427927 @default.
• W2734584105 cites W2340534089 @default.
• W2734584105 cites W2345590355 @default.
• W2734584105 cites W2510009205 @default.
• W2734584105 cites W2560767341 @default.
• W2734584105 cites W4253480286 @default.
• W2734584105 doi "https://doi.org/10.1038/s41598-017-06070-w" @default.
• W2734584105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5514129" @default.
• W2734584105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28717211" @default.
• W2734584105 hasPublicationYear "2017" @default.
• W2734584105 type Work @default.
• W2734584105 sameAs 2734584105 @default.
• W2734584105 citedByCount "13" @default.
• W2734584105 countsByYear W27345841052018 @default.
• W2734584105 countsByYear W27345841052019 @default.
• W2734584105 countsByYear W27345841052020 @default.
• W2734584105 countsByYear W27345841052021 @default.
• W2734584105 countsByYear W27345841052022 @default.
• W2734584105 crossrefType "journal-article" @default.
• W2734584105 hasAuthorship W2734584105A5002845612 @default.
• W2734584105 hasAuthorship W2734584105A5009941957 @default.
• W2734584105 hasAuthorship W2734584105A5035823766 @default.
• W2734584105 hasAuthorship W2734584105A5073997035 @default.
• W2734584105 hasAuthorship W2734584105A5081628715 @default.
• W2734584105 hasAuthorship W2734584105A5087049877 @default.
• W2734584105 hasAuthorship W2734584105A5089856110 @default.
• W2734584105 hasBestOaLocation W27345841051 @default.
• W2734584105 hasConcept C126322002 @default.
• W2734584105 hasConcept C134018914 @default.
• W2734584105 hasConcept C159985019 @default.
• W2734584105 hasConcept C192562407 @default.
• W2734584105 hasConcept C198826908 @default.
• W2734584105 hasConcept C203014093 @default.
• W2734584105 hasConcept C2776340970 @default.
• W2734584105 hasConcept C2777128398 @default.
• W2734584105 hasConcept C2777882243 @default.
• W2734584105 hasConcept C2779341262 @default.
• W2734584105 hasConcept C2779604457 @default.
• W2734584105 hasConcept C2781077229 @default.
• W2734584105 hasConcept C3019368612 @default.
• W2734584105 hasConcept C529295009 @default.
• W2734584105 hasConcept C54355233 @default.
• W2734584105 hasConcept C62478195 @default.
• W2734584105 hasConcept C66090201 @default.
• W2734584105 hasConcept C71924100 @default.
• W2734584105 hasConcept C86554907 @default.
• W2734584105 hasConcept C86803240 @default.
• W2734584105 hasConcept C8891405 @default.
• W2734584105 hasConcept C95444343 @default.
• W2734584105 hasConcept C98490376 @default.
• W2734584105 hasConceptScore W2734584105C126322002 @default.
• W2734584105 hasConceptScore W2734584105C134018914 @default.
• W2734584105 hasConceptScore W2734584105C159985019 @default.
• W2734584105 hasConceptScore W2734584105C192562407 @default.
• W2734584105 hasConceptScore W2734584105C198826908 @default.
• W2734584105 hasConceptScore W2734584105C203014093 @default.
• W2734584105 hasConceptScore W2734584105C2776340970 @default.
• W2734584105 hasConceptScore W2734584105C2777128398 @default.
• W2734584105 hasConceptScore W2734584105C2777882243 @default.
• W2734584105 hasConceptScore W2734584105C2779341262 @default.
• W2734584105 hasConceptScore W2734584105C2779604457 @default.
• W2734584105 hasConceptScore W2734584105C2781077229 @default.
• W2734584105 hasConceptScore W2734584105C3019368612 @default.
• W2734584105 hasConceptScore W2734584105C529295009 @default.
• W2734584105 hasConceptScore W2734584105C54355233 @default.
• W2734584105 hasConceptScore W2734584105C62478195 @default.
• W2734584105 hasConceptScore W2734584105C66090201 @default.

• next