FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2734673107> ?p ?o ?g. }

• W2734673107 endingPage "4113" @default.
• W2734673107 startingPage "4107" @default.
• W2734673107 abstract "Extensive studies have been performed on the role of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) in metabolic diseases. Our previous study reported glucose could directly regulate hexose-6-phosphate dehydrogenase (H6PDH) and 11β-HSD1. Recently, we further investigated the interplay of H6PDH and 11β-HSD1 and their roles in hepatic gluconeogenesis and insulin resistance to elucidate the importance of H6PDH and 11β-HSD1 in pathogenesis of type 2 diabetes mellitus (T2DM). T2DM rats model and H6PDH or 11β-HSD1 siRNA transfected in CBRH-7919 cells were used to explore the effect of H6PDH and 11β-HSD1 in T2DM. The results showed that the expression and activity of H6PDH and 11β-HSD1 in livers of diabetic rats were increased, with the expressions of PEPCK and G6Pase or liver corticosterone increased apparently. It also showed that H6PDH siRNA and 11β-HSD1 siRNA could inhibit the protein expression and enzyme activity by each other. With H6PDH siRNA, the enhancement of gluconeogenesis was blocked and insulin resistance stimulated by corticosterone was reduced. H6PDH and 11β-HSD1 might be the effective and prospective targets for T2DM and metabolic syndromes, based on the interplay between these two enzymes." @default.
• W2734673107 created "2017-07-21" @default.
• W2734673107 creator A5003721851 @default.
• W2734673107 creator A5011900828 @default.
• W2734673107 creator A5037989560 @default.
• W2734673107 creator A5045506728 @default.
• W2734673107 creator A5050184520 @default.
• W2734673107 creator A5074916167 @default.
• W2734673107 creator A5080733133 @default.
• W2734673107 creator A5088665887 @default.
• W2734673107 date "2017-09-01" @default.
• W2734673107 modified "2023-10-16" @default.
• W2734673107 title "Interplay between H6PDH and 11β-HSD1 implicated in the pathogenesis of type 2 diabetes mellitus" @default.
• W2734673107 cites W1519525780 @default.
• W2734673107 cites W1605768991 @default.
• W2734673107 cites W1976089177 @default.
• W2734673107 cites W1986227863 @default.
• W2734673107 cites W1986842715 @default.
• W2734673107 cites W1993859233 @default.
• W2734673107 cites W2005668937 @default.
• W2734673107 cites W2009448075 @default.
• W2734673107 cites W2018216079 @default.
• W2734673107 cites W2032653942 @default.
• W2734673107 cites W2033474018 @default.
• W2734673107 cites W2034836489 @default.
• W2734673107 cites W2035089683 @default.
• W2734673107 cites W2042443117 @default.
• W2734673107 cites W2050315451 @default.
• W2734673107 cites W2080974805 @default.
• W2734673107 cites W2081907145 @default.
• W2734673107 cites W2086635975 @default.
• W2734673107 cites W2092538513 @default.
• W2734673107 cites W2095590290 @default.
• W2734673107 cites W2119911216 @default.
• W2734673107 cites W2124988877 @default.
• W2734673107 cites W2131716668 @default.
• W2734673107 cites W2149304537 @default.
• W2734673107 cites W2150815175 @default.
• W2734673107 cites W2150925908 @default.
• W2734673107 cites W2164203053 @default.
• W2734673107 cites W2171475196 @default.
• W2734673107 cites W2410139253 @default.
• W2734673107 doi "https://doi.org/10.1016/j.bmcl.2017.07.043" @default.
• W2734673107 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5594562" @default.
• W2734673107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28751144" @default.
• W2734673107 hasPublicationYear "2017" @default.
• W2734673107 type Work @default.
• W2734673107 sameAs 2734673107 @default.
• W2734673107 citedByCount "5" @default.
• W2734673107 countsByYear W27346731072019 @default.
• W2734673107 countsByYear W27346731072021 @default.
• W2734673107 countsByYear W27346731072023 @default.
• W2734673107 crossrefType "journal-article" @default.
• W2734673107 hasAuthorship W2734673107A5003721851 @default.
• W2734673107 hasAuthorship W2734673107A5011900828 @default.
• W2734673107 hasAuthorship W2734673107A5037989560 @default.
• W2734673107 hasAuthorship W2734673107A5045506728 @default.
• W2734673107 hasAuthorship W2734673107A5050184520 @default.
• W2734673107 hasAuthorship W2734673107A5074916167 @default.
• W2734673107 hasAuthorship W2734673107A5080733133 @default.
• W2734673107 hasAuthorship W2734673107A5088665887 @default.
• W2734673107 hasBestOaLocation W27346731072 @default.
• W2734673107 hasConcept C104317684 @default.
• W2734673107 hasConcept C126322002 @default.
• W2734673107 hasConcept C134018914 @default.
• W2734673107 hasConcept C166075782 @default.
• W2734673107 hasConcept C181199279 @default.
• W2734673107 hasConcept C185592680 @default.
• W2734673107 hasConcept C20904676 @default.
• W2734673107 hasConcept C2776317432 @default.
• W2734673107 hasConcept C2777391703 @default.
• W2734673107 hasConcept C2780352252 @default.
• W2734673107 hasConcept C2780942790 @default.
• W2734673107 hasConcept C2910068830 @default.
• W2734673107 hasConcept C54009773 @default.
• W2734673107 hasConcept C55493867 @default.
• W2734673107 hasConcept C555293320 @default.
• W2734673107 hasConcept C71315377 @default.
• W2734673107 hasConcept C71924100 @default.
• W2734673107 hasConcept C86803240 @default.
• W2734673107 hasConceptScore W2734673107C104317684 @default.
• W2734673107 hasConceptScore W2734673107C126322002 @default.
• W2734673107 hasConceptScore W2734673107C134018914 @default.
• W2734673107 hasConceptScore W2734673107C166075782 @default.
• W2734673107 hasConceptScore W2734673107C181199279 @default.
• W2734673107 hasConceptScore W2734673107C185592680 @default.
• W2734673107 hasConceptScore W2734673107C20904676 @default.
• W2734673107 hasConceptScore W2734673107C2776317432 @default.
• W2734673107 hasConceptScore W2734673107C2777391703 @default.
• W2734673107 hasConceptScore W2734673107C2780352252 @default.
• W2734673107 hasConceptScore W2734673107C2780942790 @default.
• W2734673107 hasConceptScore W2734673107C2910068830 @default.
• W2734673107 hasConceptScore W2734673107C54009773 @default.
• W2734673107 hasConceptScore W2734673107C55493867 @default.
• W2734673107 hasConceptScore W2734673107C555293320 @default.
• W2734673107 hasConceptScore W2734673107C71315377 @default.
• W2734673107 hasConceptScore W2734673107C71924100 @default.
• W2734673107 hasConceptScore W2734673107C86803240 @default.

• next