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- W2734687544 abstract "// Meeta Gera 1, * , Neelesh Sharma 2, * , Mrinmoy Ghosh 1 , Do Luong Huynh 1 , Sung Jin Lee 3 , Taesun Min 1 , Taeho Kwon 1, 4 and Dong Kee Jeong 1, 4 1 Department of Animal Biotechnology, Faculty of Biotechnology, Jeju National University, Jeju, Republic of Korea 2 Division of Veterinary Medicine, Faculty of Veterinary Science and Animal Husbandry, Sher-e-Kashmi University of Agricultural Sciences and Technology, R.S. Pura, Jammu, India 3 Department of Animal Biotechnology, College of Animal Bioscience and Technology, Kangwon National University, Gangwon-do, Republic of Korea 4 Laboratory of Animal Genetic Engineering and Stem Cell Biology, Subtropical/Tropical Organism Gene Bank, Jeju National University, Jeju, Republic of Korea * These authors contributed equally to this work Correspondence to: Dong Kee Jeong, email: ngejeong@gmail.com , dkjeong@jejunu.ac.kr Taeho Kwon, email: taehokwonk@gmail.com Keywords: curcumin, herb, nano, nanoformulation, nanotechnology Received: May 26, 2017 Accepted: June 29, 2017 Published: July 11, 2017 ABSTRACT Curcumin is a natural polyphenol and essential curcuminoid derived from the rhizome of the medicinal plant Curcuma longa ( L .) is universally acknowledged as “ Wonder drug of life ”. It is a vital consumable and restorative herb, commonly keened for several ailments such as cancer, arthritis, pain, bruises, gastrointestinal quandaries, swelling and much more. Despite its enormous curative potential, the poor aqueous solubility and consequently, minimal systemic bioavailability with rapid degradation are some of the major factors which restrict the utilization of curcumin at medical perspective. However, to improve its clinically relevant parameters, nanoformulation of curcumin is emerging as a novel substitute for their superior therapeutic modality. It enhances its aqueous solubility and targeted delivery to the tissue of interest that prompts to enhance the bioavailability, better drug conveyance, and more expeditious treatment. Subsequent investigations are endeavored to enhance the bio-distribution of native curcumin by modifying with felicitous nano-carriers for encapsulation. In this review, we specifically focus on the recent nanotechnology based implementations applied for overcoming the innate constraints of native curcumin and additionally the associated challenges which restrict its potential therapeutic applications both in vivo and in-vitro studies, as well as their detailed mechanism of action, have additionally been discussed." @default.
- W2734687544 created "2017-07-21" @default.
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- W2734687544 date "2017-07-11" @default.
- W2734687544 modified "2023-10-11" @default.
- W2734687544 title "Nanoformulations of curcumin: an emerging paradigm for improved remedial application" @default.
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