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- W2734719308 abstract "In modern medicine, commonly used biomaterials originating from metals, ceramics and polymers have shown biocompatibility with blood, tissues, cells, etc., in the human body. Polymeric biomaterials are usually understood as polymeric materials and articles made from them which are used in medicine, biotechnology biomedicine, bioengineering, pharmaceutical, veterinary, food industry, agriculture and related fields. In this in vitro study, swellings and the biocompatibility of environmentally sensitive N-isopropyl acrylamide-based (ES) hydrogels such as N-isopropyl acrylamide/acrylamide (ES/0), and N-isopropyl acrylamide/acrylamide/ carboxylic acids (ES/XAc) prepared by free radical polymerization in aqueous solutions has been investigated. Selected carboxylic acids for this study were acrylic, methacrylic, crotonic, itaconic, maleic, mesaconic and aconitic acid. The equilibrium swelling of the hydrogels are investigated in simulated physiological fluids or crystalloid solutions such as HCl-KCl buffer (pH = 1.1), universal buffer (pH = 5.5), phosphate buffer (pH = 7.4), urea, isotonic NaCl, isotonic KCl, 5% dextrose, 5% dextrose+isotonic NaCl, Ringer's lactate, human blood serum and human serum albumin solution at 37°C. For the analysis of biocompatibility, ES hydrogels are incubated in 5 different human sera and their biocompatibilities with some biochemical parameters have been investigated for 24 h at 37°C. No significant differences in values before and after the test procedures have been found. It is therefore concluded that environmentally sensitive N-isopropyl acrylamide-based hydrogels are biocompatible for biochemical parameters of human sera." @default.
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- W2734719308 date "2017-07-03" @default.
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- W2734719308 title "<i>In vitro</i> swelling studies in simulated physiological solutions and biocompatibility of NIPAM-based hydrogels with some biochemical parameters of human sera" @default.
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- W2734719308 doi "https://doi.org/10.1080/10601325.2017.1320749" @default.
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