Matches in SemOpenAlex for { <https://semopenalex.org/work/W2734804530> ?p ?o ?g. }
- W2734804530 abstract "The brain is a plastic organ where both the intrinsic CNS milieu and extrinsic cues play important roles in shaping and wiring neural connections. The perinatal period constitutes a critical time in central nervous system development with extensive refinement of neural connections, which are highly sensitive to fetal and neonatal compromise, such as inflammatory challenges. Emerging evidence suggests that inflammatory cells in the brain such as microglia and astrocytes are pivotal in regulating synaptic structure and function. In this article, we will review the role of glia cells in synaptic physiology and pathophysiology, including microglia-mediated elimination of synapses. We propose that activation of the immune system dynamically affects synaptic organization and function in the developing brain. We will discuss the role of neuroinflammation in altered synaptic plasticity following perinatal inflammatory challenges and potential implications for neurodevelopmental and neurodegenerative disorders." @default.
- W2734804530 created "2017-07-21" @default.
- W2734804530 creator A5029843036 @default.
- W2734804530 creator A5030623189 @default.
- W2734804530 creator A5048876487 @default.
- W2734804530 creator A5057002336 @default.
- W2734804530 creator A5066369911 @default.
- W2734804530 creator A5089166254 @default.
- W2734804530 date "2017-07-11" @default.
- W2734804530 modified "2023-10-14" @default.
- W2734804530 title "Effect of Neuroinflammation on Synaptic Organization and Function in the Developing Brain: Implications for Neurodevelopmental and Neurodegenerative Disorders" @default.
- W2734804530 cites W1485248315 @default.
- W2734804530 cites W1490521057 @default.
- W2734804530 cites W1564335246 @default.
- W2734804530 cites W1588992136 @default.
- W2734804530 cites W1592653149 @default.
- W2734804530 cites W1670760818 @default.
- W2734804530 cites W1694984064 @default.
- W2734804530 cites W1785970105 @default.
- W2734804530 cites W1825929091 @default.
- W2734804530 cites W1904307646 @default.
- W2734804530 cites W1911306676 @default.
- W2734804530 cites W1924197082 @default.
- W2734804530 cites W1932095716 @default.
- W2734804530 cites W1937405158 @default.
- W2734804530 cites W1939600354 @default.
- W2734804530 cites W1965942744 @default.
- W2734804530 cites W1970593130 @default.
- W2734804530 cites W1971335207 @default.
- W2734804530 cites W1972076139 @default.
- W2734804530 cites W1973478979 @default.
- W2734804530 cites W1973897310 @default.
- W2734804530 cites W1974842721 @default.
- W2734804530 cites W1975569298 @default.
- W2734804530 cites W1975755498 @default.
- W2734804530 cites W1975952150 @default.
- W2734804530 cites W1977710969 @default.
- W2734804530 cites W1978238793 @default.
- W2734804530 cites W1979919872 @default.
- W2734804530 cites W1979978856 @default.
- W2734804530 cites W1980789245 @default.
- W2734804530 cites W1982776305 @default.
- W2734804530 cites W1983389236 @default.
- W2734804530 cites W1984618862 @default.
- W2734804530 cites W1985420125 @default.
- W2734804530 cites W1986563644 @default.
- W2734804530 cites W1987066375 @default.
- W2734804530 cites W1987282578 @default.
- W2734804530 cites W1988011192 @default.
- W2734804530 cites W1988682809 @default.
- W2734804530 cites W1988993009 @default.
- W2734804530 cites W1989369404 @default.
- W2734804530 cites W1994517931 @default.
- W2734804530 cites W1996024251 @default.
- W2734804530 cites W1996603253 @default.
- W2734804530 cites W1996684663 @default.
- W2734804530 cites W2000329187 @default.
- W2734804530 cites W2001056499 @default.
- W2734804530 cites W2003052675 @default.
- W2734804530 cites W2004198397 @default.
- W2734804530 cites W2008387841 @default.
- W2734804530 cites W2008967810 @default.
- W2734804530 cites W2010239782 @default.
- W2734804530 cites W2010994321 @default.
- W2734804530 cites W2011441557 @default.
- W2734804530 cites W2014414485 @default.
- W2734804530 cites W2014780789 @default.
- W2734804530 cites W2015407094 @default.
- W2734804530 cites W2015636063 @default.
- W2734804530 cites W2016575029 @default.
- W2734804530 cites W2017201962 @default.
- W2734804530 cites W2017762661 @default.
- W2734804530 cites W2017951103 @default.
- W2734804530 cites W2018710502 @default.
- W2734804530 cites W2019163583 @default.
- W2734804530 cites W2020407498 @default.
- W2734804530 cites W2020577923 @default.
- W2734804530 cites W2020651859 @default.
- W2734804530 cites W2020828007 @default.
- W2734804530 cites W2021087861 @default.
- W2734804530 cites W2022959185 @default.
- W2734804530 cites W2024662441 @default.
- W2734804530 cites W2026510962 @default.
- W2734804530 cites W2029190354 @default.
- W2734804530 cites W2031611126 @default.
- W2734804530 cites W2032877933 @default.
- W2734804530 cites W2033617297 @default.
- W2734804530 cites W2035471044 @default.
- W2734804530 cites W2036581163 @default.
- W2734804530 cites W2038526309 @default.
- W2734804530 cites W2039450535 @default.
- W2734804530 cites W2040268226 @default.
- W2734804530 cites W2040336122 @default.
- W2734804530 cites W2041812587 @default.
- W2734804530 cites W2042311033 @default.
- W2734804530 cites W2044216636 @default.
- W2734804530 cites W2045042214 @default.
- W2734804530 cites W2048843644 @default.
- W2734804530 cites W2049658840 @default.
- W2734804530 cites W2051378734 @default.