Matches in SemOpenAlex for { <https://semopenalex.org/work/W2734825151> ?p ?o ?g. }
- W2734825151 endingPage "9" @default.
- W2734825151 startingPage "1" @default.
- W2734825151 abstract "Aim . To investigate whether overexpression of Brahma-related gene-1 (Brg1) can alleviate lung injury induced by hepatic ischemia/reperfusion (HIR) and its precise mechanism. Methods . Cytomegalovirus-transgenic Brg1-overexpressing (CMV-Brg1) mice and wild-type (WT) C57BL/6 mice underwent HIR. Lung histology, oxidative injury markers, and antioxidant enzyme concentrations in the lung were assessed. The protein expression levels of Brg1, nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and NAD(P)H:quinone oxidoreductase 1 (NQO1) in the lung were analyzed by Western blotting. Results . In the WT group, histopathological analysis revealed that lung damage peaked at 6 h after HIR. Meanwhile, the lung reactive oxygen species (ROS) and 8-isoprostane levels were significantly increased. The protein expression of Brg1 in lung tissue decreased to a minimum at 6 h. Overexpression of Brg1 alleviated lung injury and decreased the amounts of oxidative products, including the levels of 8-isoprostane and ROS, as well as the percentage of positive cells for 4-hydroxynonenal (4-HNE) and 8-oxo-2′-deoxyguanosine (8-OHdG). Brg1 overexpression increased the expression and nuclear translocation of Nrf2 as well as activated the antioxidases. In addition, it decreased the expression of inflammatory factors. Conclusion . Overexpression of Brg1 alleviates oxidative lung injury induced by HIR, likely through the Nrf2 pathway." @default.
- W2734825151 created "2017-07-21" @default.
- W2734825151 creator A5013794662 @default.
- W2734825151 creator A5022629608 @default.
- W2734825151 creator A5025050046 @default.
- W2734825151 creator A5030422886 @default.
- W2734825151 creator A5050756282 @default.
- W2734825151 creator A5087980819 @default.
- W2734825151 date "2017-01-01" @default.
- W2734825151 modified "2023-10-12" @default.
- W2734825151 title "Overexpression of Brg1 Alleviates Hepatic Ischemia/Reperfusion-Induced Acute Lung Injury through Antioxidative Stress Effects" @default.
- W2734825151 cites W1499199667 @default.
- W2734825151 cites W1525965209 @default.
- W2734825151 cites W1767659454 @default.
- W2734825151 cites W1963737649 @default.
- W2734825151 cites W1975393873 @default.
- W2734825151 cites W1977738457 @default.
- W2734825151 cites W1985220620 @default.
- W2734825151 cites W1986188587 @default.
- W2734825151 cites W1987857240 @default.
- W2734825151 cites W1988756130 @default.
- W2734825151 cites W1990410993 @default.
- W2734825151 cites W1991207338 @default.
- W2734825151 cites W1995887352 @default.
- W2734825151 cites W1999977429 @default.
- W2734825151 cites W2014690573 @default.
- W2734825151 cites W2022222653 @default.
- W2734825151 cites W2036942359 @default.
- W2734825151 cites W2050240400 @default.
- W2734825151 cites W2050440217 @default.
- W2734825151 cites W2063543841 @default.
- W2734825151 cites W2074100870 @default.
- W2734825151 cites W2079793058 @default.
- W2734825151 cites W2080247199 @default.
- W2734825151 cites W2087094528 @default.
- W2734825151 cites W2094585847 @default.
- W2734825151 cites W2100300716 @default.
- W2734825151 cites W2126973029 @default.
- W2734825151 cites W2128110268 @default.
- W2734825151 cites W2132955371 @default.
- W2734825151 cites W2138625851 @default.
- W2734825151 cites W2151181348 @default.
- W2734825151 cites W2153400801 @default.
- W2734825151 cites W2155343943 @default.
- W2734825151 cites W2186909212 @default.
- W2734825151 cites W2267232367 @default.
- W2734825151 cites W2396422681 @default.
- W2734825151 cites W2417632595 @default.
- W2734825151 cites W2513056618 @default.
- W2734825151 doi "https://doi.org/10.1155/2017/8787392" @default.
- W2734825151 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5534314" @default.
- W2734825151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28798861" @default.
- W2734825151 hasPublicationYear "2017" @default.
- W2734825151 type Work @default.
- W2734825151 sameAs 2734825151 @default.
- W2734825151 citedByCount "21" @default.
- W2734825151 countsByYear W27348251512018 @default.
- W2734825151 countsByYear W27348251512019 @default.
- W2734825151 countsByYear W27348251512020 @default.
- W2734825151 countsByYear W27348251512021 @default.
- W2734825151 countsByYear W27348251512022 @default.
- W2734825151 countsByYear W27348251512023 @default.
- W2734825151 crossrefType "journal-article" @default.
- W2734825151 hasAuthorship W2734825151A5013794662 @default.
- W2734825151 hasAuthorship W2734825151A5022629608 @default.
- W2734825151 hasAuthorship W2734825151A5025050046 @default.
- W2734825151 hasAuthorship W2734825151A5030422886 @default.
- W2734825151 hasAuthorship W2734825151A5050756282 @default.
- W2734825151 hasAuthorship W2734825151A5087980819 @default.
- W2734825151 hasBestOaLocation W27348251511 @default.
- W2734825151 hasConcept C126322002 @default.
- W2734825151 hasConcept C142724271 @default.
- W2734825151 hasConcept C153911025 @default.
- W2734825151 hasConcept C185592680 @default.
- W2734825151 hasConcept C2776151105 @default.
- W2734825151 hasConcept C2777714996 @default.
- W2734825151 hasConcept C2780114680 @default.
- W2734825151 hasConcept C48349386 @default.
- W2734825151 hasConcept C541997718 @default.
- W2734825151 hasConcept C55493867 @default.
- W2734825151 hasConcept C71924100 @default.
- W2734825151 hasConcept C86803240 @default.
- W2734825151 hasConceptScore W2734825151C126322002 @default.
- W2734825151 hasConceptScore W2734825151C142724271 @default.
- W2734825151 hasConceptScore W2734825151C153911025 @default.
- W2734825151 hasConceptScore W2734825151C185592680 @default.
- W2734825151 hasConceptScore W2734825151C2776151105 @default.
- W2734825151 hasConceptScore W2734825151C2777714996 @default.
- W2734825151 hasConceptScore W2734825151C2780114680 @default.
- W2734825151 hasConceptScore W2734825151C48349386 @default.
- W2734825151 hasConceptScore W2734825151C541997718 @default.
- W2734825151 hasConceptScore W2734825151C55493867 @default.
- W2734825151 hasConceptScore W2734825151C71924100 @default.
- W2734825151 hasConceptScore W2734825151C86803240 @default.
- W2734825151 hasFunder F4320321921 @default.
- W2734825151 hasLocation W27348251511 @default.
- W2734825151 hasLocation W27348251512 @default.
- W2734825151 hasLocation W27348251513 @default.