FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2734851812> ?p ?o ?g. }

• W2734851812 endingPage "1307" @default.
• W2734851812 startingPage "1269" @default.
• W2734851812 abstract "The knifefish Apteronotus leptorhynchus exhibits indeterminate growth throughout adulthood. This phenomenon extends to the spinal cord, presumably through the continuous addition of new neurons and glial cells. However, little is known about the developmental dynamics of cells added during adult growth. The present work characterizes the structural and functional development of the adult spinal cord in this model organism through a comprehensive quantitative analysis of the spatial and temporal dynamics of new cells at various developmental stages. This analysis, based on a novel statistical mapping approach, revealed within the adult spinal cord a wide distribution of both mitotically active and quiescent Sox2-expressing stem/progenitor cells (SPCs). While such cells are particularly concentrated within the ependymal layer near the central canal, the majority of them reside in the parenchyma, resembling the distribution of SPCs observed in the mammalian spinal cord. The active SPCs in the adult knifefish spinal cord give rise to transit amplifying progenitor cells that undergo a few additional mitotic divisions before developing into Hu C/D+ neurons and S100+ glial cells. There is no evidence of long-distance migration of the newborn cells. The persistence of cell proliferation and differentiation, combined with low levels of apoptosis, leads to a continuous addition of cells to the existing tissue. Newly generated neurons have functional and behavioral relevance, as indicated by the integration of axons of new electromotor neurons into the electric organ of these weakly electric fish. This results in a gradual increase in the amplitude of the electric organ discharge during adult development. © 2017 Wiley Periodicals, Inc. Develop Neurobiol 77: 1269-1307, 2017." @default.
• W2734851812 created "2017-07-21" @default.
• W2734851812 creator A5040336561 @default.
• W2734851812 creator A5041514896 @default.
• W2734851812 creator A5063791254 @default.
• W2734851812 creator A5064974795 @default.
• W2734851812 date "2017-07-23" @default.
• W2734851812 modified "2023-10-05" @default.
• W2734851812 title "Additive neurogenesis supported by multiple stem cell populations mediates adult spinal cord development: A spatiotemporal statistical mapping analysis in a teleost model of indeterminate growth" @default.
• W2734851812 cites W146465976 @default.
• W2734851812 cites W1484682139 @default.
• W2734851812 cites W1548529611 @default.
• W2734851812 cites W1588589996 @default.
• W2734851812 cites W1605713324 @default.
• W2734851812 cites W1681854062 @default.
• W2734851812 cites W1873726593 @default.
• W2734851812 cites W1926446950 @default.
• W2734851812 cites W1964287628 @default.
• W2734851812 cites W1965676841 @default.
• W2734851812 cites W1968743318 @default.
• W2734851812 cites W1974791004 @default.
• W2734851812 cites W1977142827 @default.
• W2734851812 cites W1977243099 @default.
• W2734851812 cites W1983456059 @default.
• W2734851812 cites W1988237222 @default.
• W2734851812 cites W1988642487 @default.
• W2734851812 cites W1988672114 @default.
• W2734851812 cites W1990757785 @default.
• W2734851812 cites W1991524392 @default.
• W2734851812 cites W1992949974 @default.
• W2734851812 cites W1994246059 @default.
• W2734851812 cites W1996814444 @default.
• W2734851812 cites W1998560054 @default.
• W2734851812 cites W1999321510 @default.
• W2734851812 cites W2003342297 @default.
• W2734851812 cites W2007899536 @default.
• W2734851812 cites W2008428949 @default.
• W2734851812 cites W2008468514 @default.
• W2734851812 cites W2008542095 @default.
• W2734851812 cites W2011545180 @default.
• W2734851812 cites W2012370126 @default.
• W2734851812 cites W2013485257 @default.
• W2734851812 cites W2016500868 @default.
• W2734851812 cites W2017354392 @default.
• W2734851812 cites W2018219363 @default.
• W2734851812 cites W2019491036 @default.
• W2734851812 cites W2021389321 @default.
• W2734851812 cites W2023408311 @default.
• W2734851812 cites W2027600088 @default.
• W2734851812 cites W2031683488 @default.
• W2734851812 cites W2031885689 @default.
• W2734851812 cites W2035222904 @default.
• W2734851812 cites W2036692702 @default.
• W2734851812 cites W2039565605 @default.
• W2734851812 cites W2042154782 @default.
• W2734851812 cites W2044654272 @default.
• W2734851812 cites W2048109276 @default.
• W2734851812 cites W2050029057 @default.
• W2734851812 cites W2067443777 @default.
• W2734851812 cites W2077690723 @default.
• W2734851812 cites W2086630567 @default.
• W2734851812 cites W2088420522 @default.
• W2734851812 cites W2092411481 @default.
• W2734851812 cites W2094972585 @default.
• W2734851812 cites W2096196767 @default.
• W2734851812 cites W2097673222 @default.
• W2734851812 cites W2108204976 @default.
• W2734851812 cites W2108696510 @default.
• W2734851812 cites W2112291646 @default.
• W2734851812 cites W2115290127 @default.
• W2734851812 cites W2117506912 @default.
• W2734851812 cites W2119248217 @default.
• W2734851812 cites W2123048941 @default.
• W2734851812 cites W2127447774 @default.
• W2734851812 cites W2130283023 @default.
• W2734851812 cites W2132918091 @default.
• W2734851812 cites W2138932739 @default.
• W2734851812 cites W2139481908 @default.
• W2734851812 cites W2144109983 @default.
• W2734851812 cites W2157706971 @default.
• W2734851812 cites W2163135664 @default.
• W2734851812 cites W2165224884 @default.
• W2734851812 cites W2165654213 @default.
• W2734851812 cites W2165867905 @default.
• W2734851812 cites W2169508723 @default.
• W2734851812 cites W2172266256 @default.
• W2734851812 cites W2181294258 @default.
• W2734851812 cites W2274964616 @default.
• W2734851812 cites W2558745632 @default.
• W2734851812 cites W2598950346 @default.
• W2734851812 cites W327509237 @default.
• W2734851812 cites W4211213555 @default.
• W2734851812 doi "https://doi.org/10.1002/dneu.22511" @default.
• W2734851812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28707354" @default.
• W2734851812 hasPublicationYear "2017" @default.
• W2734851812 type Work @default.
• W2734851812 sameAs 2734851812 @default.
• W2734851812 citedByCount "20" @default.

• next