FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2735002078> ?p ?o ?g. }

• W2735002078 abstract "Abstract Yeast Cdc48 is a well-conserved, essential chaperone of ATPases associated with diverse cellular activity (AAA) proteins, which recognizes substrate proteins and modulates their conformations to carry out many cellular processes. However, the fundamental mechanisms underlying the diverse pivotal roles of Cdc48 remain unknown. Almost all AAA proteins form a ring-shaped structure with a conserved aromatic amino acid residue that is essential for proper function. The threading mechanism hypothesis suggests that this residue guides the intrusion of substrate proteins into a narrow pore of the AAA ring, thereby becoming unfolded. By contrast, the aromatic residue in one of the two AAA rings of Cdc48 has been eliminated through evolution. Here, we show that artificial retrieval of this aromatic residue in Cdc48 is lethal, and essential features to support the threading mechanism are required to exhibit the lethal phenotype. In particular, genetic and biochemical analyses of the Cdc48 lethal mutant strongly suggested that when in complex with the 20S proteasome, essential proteins are abnormally forced to thread through the Cdc48 pore to become degraded, which was not detected in wild-type Cdc48. Thus, the widely applicable threading model is less effective for wild-type Cdc48; rather, Cdc48 might function predominantly through an as-yet-undetermined mechanism." @default.
• W2735002078 created "2017-07-21" @default.
• W2735002078 creator A5004748763 @default.
• W2735002078 creator A5015534186 @default.
• W2735002078 creator A5052960601 @default.
• W2735002078 creator A5072887604 @default.
• W2735002078 date "2017-07-14" @default.
• W2735002078 modified "2023-09-27" @default.
• W2735002078 title "Deviation of the typical AAA substrate-threading pore prevents fatal protein degradation in yeast Cdc48" @default.
• W2735002078 cites W1536729166 @default.
• W2735002078 cites W1968261679 @default.
• W2735002078 cites W1969750928 @default.
• W2735002078 cites W1973024953 @default.
• W2735002078 cites W1978160215 @default.
• W2735002078 cites W1983813028 @default.
• W2735002078 cites W1988725811 @default.
• W2735002078 cites W1990265320 @default.
• W2735002078 cites W1997165681 @default.
• W2735002078 cites W2010958487 @default.
• W2735002078 cites W2023791134 @default.
• W2735002078 cites W2036585962 @default.
• W2735002078 cites W2038794428 @default.
• W2735002078 cites W2044086279 @default.
• W2735002078 cites W2047455709 @default.
• W2735002078 cites W2048240388 @default.
• W2735002078 cites W2048953337 @default.
• W2735002078 cites W2050370747 @default.
• W2735002078 cites W2057283530 @default.
• W2735002078 cites W2059265460 @default.
• W2735002078 cites W2061093994 @default.
• W2735002078 cites W2061259593 @default.
• W2735002078 cites W2078813054 @default.
• W2735002078 cites W2081578559 @default.
• W2735002078 cites W2082541885 @default.
• W2735002078 cites W2083848910 @default.
• W2735002078 cites W2087221323 @default.
• W2735002078 cites W2087436338 @default.
• W2735002078 cites W2092103430 @default.
• W2735002078 cites W2093338032 @default.
• W2735002078 cites W2094519502 @default.
• W2735002078 cites W2098671490 @default.
• W2735002078 cites W2100599614 @default.
• W2735002078 cites W2103355923 @default.
• W2735002078 cites W2114705132 @default.
• W2735002078 cites W2118480670 @default.
• W2735002078 cites W2120131503 @default.
• W2735002078 cites W2122139514 @default.
• W2735002078 cites W2133406524 @default.
• W2735002078 cites W2139837621 @default.
• W2735002078 cites W2141284487 @default.
• W2735002078 cites W2160087776 @default.
• W2735002078 cites W2169333620 @default.
• W2735002078 cites W2184159865 @default.
• W2735002078 cites W2530354305 @default.
• W2735002078 cites W2610240952 @default.
• W2735002078 cites W4234287785 @default.
• W2735002078 doi "https://doi.org/10.1038/s41598-017-05806-y" @default.
• W2735002078 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5511170" @default.
• W2735002078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28710470" @default.
• W2735002078 hasPublicationYear "2017" @default.
• W2735002078 type Work @default.
• W2735002078 sameAs 2735002078 @default.
• W2735002078 citedByCount "22" @default.
• W2735002078 countsByYear W27350020782018 @default.
• W2735002078 countsByYear W27350020782019 @default.
• W2735002078 countsByYear W27350020782020 @default.
• W2735002078 countsByYear W27350020782021 @default.
• W2735002078 countsByYear W27350020782022 @default.
• W2735002078 countsByYear W27350020782023 @default.
• W2735002078 crossrefType "journal-article" @default.
• W2735002078 hasAuthorship W2735002078A5004748763 @default.
• W2735002078 hasAuthorship W2735002078A5015534186 @default.
• W2735002078 hasAuthorship W2735002078A5052960601 @default.
• W2735002078 hasAuthorship W2735002078A5072887604 @default.
• W2735002078 hasBestOaLocation W27350020781 @default.
• W2735002078 hasConcept C101635128 @default.
• W2735002078 hasConcept C104292427 @default.
• W2735002078 hasConcept C104317684 @default.
• W2735002078 hasConcept C127716648 @default.
• W2735002078 hasConcept C142724271 @default.
• W2735002078 hasConcept C143065580 @default.
• W2735002078 hasConcept C181199279 @default.
• W2735002078 hasConcept C185592680 @default.
• W2735002078 hasConcept C200307862 @default.
• W2735002078 hasConcept C204328495 @default.
• W2735002078 hasConcept C23265538 @default.
• W2735002078 hasConcept C25602115 @default.
• W2735002078 hasConcept C2775962898 @default.
• W2735002078 hasConcept C2777576037 @default.
• W2735002078 hasConcept C2779222958 @default.
• W2735002078 hasConcept C2992195973 @default.
• W2735002078 hasConcept C47701112 @default.
• W2735002078 hasConcept C55493867 @default.
• W2735002078 hasConcept C71924100 @default.
• W2735002078 hasConcept C86803240 @default.
• W2735002078 hasConcept C95444343 @default.
• W2735002078 hasConceptScore W2735002078C101635128 @default.
• W2735002078 hasConceptScore W2735002078C104292427 @default.
• W2735002078 hasConceptScore W2735002078C104317684 @default.
• W2735002078 hasConceptScore W2735002078C127716648 @default.

• next