FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2735005430> ?p ?o ?g. }

• W2735005430 endingPage "1219" @default.
• W2735005430 startingPage "1211" @default.
• W2735005430 abstract "Prenatal lipopolysaccharide (LPS) exposure causes hypertension in rat offspring through an unknown mechanism. Here, we investigated the role of the intrarenal renin–angiotensin system (RAS) in hypertension induced by prenatal LPS exposure and also explored whether adipose tissue-derived mesenchymal stem cells (ADSCs) can ameliorate the effects of prenatal LPS exposure in rat offspring. Sixty-four pregnant rats were randomly divided into 4 groups (n = 16 in each), namely, a control group and an LPS group, which were intraperitoneally injected with vehicle and 0.79 mg/kg LPS, respectively, on the 8th, 10th, and 12th days of gestation; an ADSCs group, which was intravenously injected with 1.8 × 107 ADSCs on the 8th, 10th, and 12th days of gestation; and an LPS + ADSCs group, which received a combination of the treatments administered to the LPS and ADSCs groups. Prenatal LPS exposure increased blood pressure, Ang II expression, Ang II-positive, monocyte and lymphocyte, apoptotic cells in the kidney, and induced renal histological changes in offspring; however, the LPS and control groups did not differ significantly with respect to plasma renin activity levels, Ang II levels, or renal function. ADSCs treatment attenuated the blood pressure and also ameliorated the other effects of LPS-treated adult offspring. Prenatal exposure to LPS activates the intrarenal RAS but not the circulating RAS and thus induces increases in blood pressure in adult offspring; however, ADSCs treatment attenuates the blood pressure increases resulting from LPS exposure and also ameliorates the other phenotypic changes induced by LPS treatment by inhibiting intrarenal RAS activation." @default.
• W2735005430 created "2017-07-21" @default.
• W2735005430 creator A5003607123 @default.
• W2735005430 creator A5003854775 @default.
• W2735005430 creator A5003972308 @default.
• W2735005430 creator A5013953637 @default.
• W2735005430 creator A5014195696 @default.
• W2735005430 creator A5017183825 @default.
• W2735005430 creator A5030557960 @default.
• W2735005430 creator A5034765475 @default.
• W2735005430 creator A5036018905 @default.
• W2735005430 creator A5036143268 @default.
• W2735005430 creator A5063224196 @default.
• W2735005430 creator A5074922099 @default.
• W2735005430 creator A5076064713 @default.
• W2735005430 creator A5083800093 @default.
• W2735005430 date "2017-07-15" @default.
• W2735005430 modified "2023-10-18" @default.
• W2735005430 title "Prenatal Exposure to LPS Alters The Intrarenal RAS in Offspring, Which Is Ameliorated by Adipose Tissue-Derived Mesenchymal Stem Cells" @default.
• W2735005430 cites W1832138980 @default.
• W2735005430 cites W1966909084 @default.
• W2735005430 cites W1987514832 @default.
• W2735005430 cites W2003942853 @default.
• W2735005430 cites W2010955535 @default.
• W2735005430 cites W2013216543 @default.
• W2735005430 cites W2025371271 @default.
• W2735005430 cites W2030880796 @default.
• W2735005430 cites W2034536217 @default.
• W2735005430 cites W2075230812 @default.
• W2735005430 cites W2082253016 @default.
• W2735005430 cites W2087483610 @default.
• W2735005430 cites W2096221523 @default.
• W2735005430 cites W2098698668 @default.
• W2735005430 cites W2103550033 @default.
• W2735005430 cites W2106727620 @default.
• W2735005430 cites W2114074520 @default.
• W2735005430 cites W2115604864 @default.
• W2735005430 cites W2131460202 @default.
• W2735005430 cites W2140498210 @default.
• W2735005430 cites W2143036087 @default.
• W2735005430 cites W2159764327 @default.
• W2735005430 cites W2162673717 @default.
• W2735005430 cites W2566599147 @default.
• W2735005430 doi "https://doi.org/10.1093/ajh/hpx117" @default.
• W2735005430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28992100" @default.
• W2735005430 hasPublicationYear "2017" @default.
• W2735005430 type Work @default.
• W2735005430 sameAs 2735005430 @default.
• W2735005430 citedByCount "5" @default.
• W2735005430 countsByYear W27350054302019 @default.
• W2735005430 countsByYear W27350054302020 @default.
• W2735005430 crossrefType "journal-article" @default.
• W2735005430 hasAuthorship W2735005430A5003607123 @default.
• W2735005430 hasAuthorship W2735005430A5003854775 @default.
• W2735005430 hasAuthorship W2735005430A5003972308 @default.
• W2735005430 hasAuthorship W2735005430A5013953637 @default.
• W2735005430 hasAuthorship W2735005430A5014195696 @default.
• W2735005430 hasAuthorship W2735005430A5017183825 @default.
• W2735005430 hasAuthorship W2735005430A5030557960 @default.
• W2735005430 hasAuthorship W2735005430A5034765475 @default.
• W2735005430 hasAuthorship W2735005430A5036018905 @default.
• W2735005430 hasAuthorship W2735005430A5036143268 @default.
• W2735005430 hasAuthorship W2735005430A5063224196 @default.
• W2735005430 hasAuthorship W2735005430A5074922099 @default.
• W2735005430 hasAuthorship W2735005430A5076064713 @default.
• W2735005430 hasAuthorship W2735005430A5083800093 @default.
• W2735005430 hasBestOaLocation W27350054301 @default.
• W2735005430 hasConcept C112672928 @default.
• W2735005430 hasConcept C126322002 @default.
• W2735005430 hasConcept C134018914 @default.
• W2735005430 hasConcept C142724271 @default.
• W2735005430 hasConcept C171089720 @default.
• W2735005430 hasConcept C198826908 @default.
• W2735005430 hasConcept C2778754761 @default.
• W2735005430 hasConcept C2779234561 @default.
• W2735005430 hasConcept C2780091579 @default.
• W2735005430 hasConcept C46973012 @default.
• W2735005430 hasConcept C54355233 @default.
• W2735005430 hasConcept C71924100 @default.
• W2735005430 hasConcept C84393581 @default.
• W2735005430 hasConcept C86803240 @default.
• W2735005430 hasConceptScore W2735005430C112672928 @default.
• W2735005430 hasConceptScore W2735005430C126322002 @default.
• W2735005430 hasConceptScore W2735005430C134018914 @default.
• W2735005430 hasConceptScore W2735005430C142724271 @default.
• W2735005430 hasConceptScore W2735005430C171089720 @default.
• W2735005430 hasConceptScore W2735005430C198826908 @default.
• W2735005430 hasConceptScore W2735005430C2778754761 @default.
• W2735005430 hasConceptScore W2735005430C2779234561 @default.
• W2735005430 hasConceptScore W2735005430C2780091579 @default.
• W2735005430 hasConceptScore W2735005430C46973012 @default.
• W2735005430 hasConceptScore W2735005430C54355233 @default.
• W2735005430 hasConceptScore W2735005430C71924100 @default.
• W2735005430 hasConceptScore W2735005430C84393581 @default.
• W2735005430 hasConceptScore W2735005430C86803240 @default.
• W2735005430 hasFunder F4320321001 @default.
• W2735005430 hasIssue "12" @default.
• W2735005430 hasLocation W27350054301 @default.

• next