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- W2735020914 abstract "Articular cartilage is covered by a microscopic structure known as surface amorphous layer. This surface structure is often the first victim of attack during cartilage degeneration, thereby resulting in a gross impairment in cartilage function such as lubrication and load bearing. We hypothesize that incubation of degraded cartilage in solutions of different species of synthetic surface active phospholipids (saturated and unsaturated species) can remodel this lost surface structure. To test this hypothesis, the structural configuration of the surface of articular cartilage was studied and characterised with the lipid filled surface amorphous layer intact using the AFM. The results were then compared with those obtained following a systematic removal (delipidization) and replacement (relipidization) of this layer. Our results show that the unsaturated surfactant partially restored the lost surface amorphous layer while the saturated surfactant specie settled on the surface due to its poor solubility in aqueous solution." @default.
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- W2735020914 date "2011-01-01" @default.
- W2735020914 modified "2023-09-27" @default.
- W2735020914 title "Preliminary characterisation of the surface of cartilage following exposure to saturated and unsaturated synthetic lips" @default.
- W2735020914 hasPublicationYear "2011" @default.
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