Matches in SemOpenAlex for { <https://semopenalex.org/work/W2735040354> ?p ?o ?g. }
Showing items 1 to 57 of
57
with 100 items per page.
- W2735040354 endingPage "192" @default.
- W2735040354 startingPage "188" @default.
- W2735040354 abstract "Idiopathic pulmonary fibrosis (IPF) is a disease with limited therapeutic options. Corticosteroids and immunouppressive agents have been the mainstays of treatment, primarily due to their anti-inflammatory properties. However, they have demonstrated minimal efficacy and significant toxicity. Recent efforts have sought to target other aspects of the pathophysiology of this condition. Several investigators have hypothesized that imbalances of coagulation and fibrinolysis play a role in the pathophysiology of IPF. Thrombin has been identified as a possible trigger of fibroblast proliferation in IPF, suggesting a role for thrombin inhibition in modifying the course of disease. Furthermore, anticoagulation may have a role in preventing thrombotic complications in IPF patients with secondary pulmonary hypertension. This review will discuss the potential role for anticoagulation in the treatment of IPF. One randomised control trial has demonstrated a significant survival benefit associated with anticoagulation of IPF patients. We will review the evidence supporting this treatment strategy, as well as its possible mechanisms of action. Keywords: Idiopathic pulmonary fibrosis, anticoagulation, thrombin" @default.
- W2735040354 created "2017-07-21" @default.
- W2735040354 creator A5037376006 @default.
- W2735040354 creator A5039175808 @default.
- W2735040354 creator A5044172089 @default.
- W2735040354 date "2007-08-01" @default.
- W2735040354 modified "2023-09-25" @default.
- W2735040354 title "The Role of Anticoagulation in IPF" @default.
- W2735040354 doi "https://doi.org/10.2174/157339807781387526" @default.
- W2735040354 hasPublicationYear "2007" @default.
- W2735040354 type Work @default.
- W2735040354 sameAs 2735040354 @default.
- W2735040354 citedByCount "2" @default.
- W2735040354 countsByYear W27350403542017 @default.
- W2735040354 crossrefType "journal-article" @default.
- W2735040354 hasAuthorship W2735040354A5037376006 @default.
- W2735040354 hasAuthorship W2735040354A5039175808 @default.
- W2735040354 hasAuthorship W2735040354A5044172089 @default.
- W2735040354 hasConcept C10162356 @default.
- W2735040354 hasConcept C126322002 @default.
- W2735040354 hasConcept C177713679 @default.
- W2735040354 hasConcept C2776825266 @default.
- W2735040354 hasConcept C2777714996 @default.
- W2735040354 hasConcept C2778341716 @default.
- W2735040354 hasConcept C2778382381 @default.
- W2735040354 hasConcept C2779134260 @default.
- W2735040354 hasConcept C71924100 @default.
- W2735040354 hasConceptScore W2735040354C10162356 @default.
- W2735040354 hasConceptScore W2735040354C126322002 @default.
- W2735040354 hasConceptScore W2735040354C177713679 @default.
- W2735040354 hasConceptScore W2735040354C2776825266 @default.
- W2735040354 hasConceptScore W2735040354C2777714996 @default.
- W2735040354 hasConceptScore W2735040354C2778341716 @default.
- W2735040354 hasConceptScore W2735040354C2778382381 @default.
- W2735040354 hasConceptScore W2735040354C2779134260 @default.
- W2735040354 hasConceptScore W2735040354C71924100 @default.
- W2735040354 hasIssue "3" @default.
- W2735040354 hasLocation W27350403541 @default.
- W2735040354 hasOpenAccess W2735040354 @default.
- W2735040354 hasPrimaryLocation W27350403541 @default.
- W2735040354 hasRelatedWork W2004690682 @default.
- W2735040354 hasRelatedWork W2106119589 @default.
- W2735040354 hasRelatedWork W2216035847 @default.
- W2735040354 hasRelatedWork W2356925755 @default.
- W2735040354 hasRelatedWork W2402257114 @default.
- W2735040354 hasRelatedWork W2417853680 @default.
- W2735040354 hasRelatedWork W2427138872 @default.
- W2735040354 hasRelatedWork W2444289960 @default.
- W2735040354 hasRelatedWork W2794838774 @default.
- W2735040354 hasRelatedWork W3089631524 @default.
- W2735040354 hasVolume "3" @default.
- W2735040354 isParatext "false" @default.
- W2735040354 isRetracted "false" @default.
- W2735040354 magId "2735040354" @default.
- W2735040354 workType "article" @default.