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• W2735097030 abstract "Abstract Reproductive isolation and speciation are driven by the convergence of environmental and genetic variation. The integration of these variation sources is thought to occur through epigenetic marks including DNA methylation. Proteins containing a methyl-CpG-binding domain (MBD) bind methylated DNA and interpret epigenetic marks, providing a dynamic yet evolutionarily adapted cellular output. Here, we report the Drosophila MBD-containing proteins, dMBD-R2 and dMBD2/3, contribute to reproductive isolation and survival behavioral strategies. Drosophila melanogaster males with a reduction in dMBD-R2 specifically in octopamine (OA) neurons exhibit courtship toward divergent interspecies D. virilis and D. yakuba females and a decrease in conspecific mating success. Conspecific male-male courtship is increased between dMBD-R2-deficient males while aggression is reduced. These changes in adaptive behavior are separable as males with a hypermethylated OA neuronal genome exhibited a decrease in aggression without altering male-male courtship. These results suggest Drosophila MBD-containing proteins are required within the OA neural circuitry to inhibit interspecies and conspecific male-male courtship and indicate that the genetically hard-wired neural mechanisms enforcing behavioral reproductive isolation include the interpretation of the epigenome." @default.
• W2735097030 created "2017-07-21" @default.
• W2735097030 creator A5005820505 @default.
• W2735097030 creator A5008486686 @default.
• W2735097030 creator A5022148929 @default.
• W2735097030 creator A5025379806 @default.
• W2735097030 creator A5065587833 @default.
• W2735097030 date "2017-07-14" @default.
• W2735097030 modified "2023-10-18" @default.
• W2735097030 title "Methyl-CpG binding domain proteins inhibit interspecies courtship and promote aggression in Drosophila" @default.
• W2735097030 cites W1481867552 @default.
• W2735097030 cites W1505720065 @default.
• W2735097030 cites W1508163514 @default.
• W2735097030 cites W1531810803 @default.
• W2735097030 cites W1578539153 @default.
• W2735097030 cites W1671585986 @default.
• W2735097030 cites W1749072204 @default.
• W2735097030 cites W176153765 @default.
• W2735097030 cites W1784857457 @default.
• W2735097030 cites W1833314573 @default.
• W2735097030 cites W1967117492 @default.
• W2735097030 cites W1971930614 @default.
• W2735097030 cites W1975497776 @default.
• W2735097030 cites W1980827571 @default.
• W2735097030 cites W1982163053 @default.
• W2735097030 cites W1987924209 @default.
• W2735097030 cites W1991667131 @default.
• W2735097030 cites W1992789817 @default.
• W2735097030 cites W1994534319 @default.
• W2735097030 cites W1994713392 @default.
• W2735097030 cites W1996361773 @default.
• W2735097030 cites W1998038483 @default.
• W2735097030 cites W2001207460 @default.
• W2735097030 cites W2003985631 @default.
• W2735097030 cites W2007635413 @default.
• W2735097030 cites W2012302008 @default.
• W2735097030 cites W2015669676 @default.
• W2735097030 cites W2016802710 @default.
• W2735097030 cites W2019197788 @default.
• W2735097030 cites W2019474060 @default.
• W2735097030 cites W2023331548 @default.
• W2735097030 cites W2024391660 @default.
• W2735097030 cites W2027108048 @default.
• W2735097030 cites W2028508619 @default.
• W2735097030 cites W2029741050 @default.
• W2735097030 cites W2032176996 @default.
• W2735097030 cites W2034946403 @default.
• W2735097030 cites W2035616108 @default.
• W2735097030 cites W2039528431 @default.
• W2735097030 cites W2039879202 @default.
• W2735097030 cites W2041174212 @default.
• W2735097030 cites W2049888367 @default.
• W2735097030 cites W2052546754 @default.
• W2735097030 cites W2053950534 @default.
• W2735097030 cites W2058815724 @default.
• W2735097030 cites W2058998028 @default.
• W2735097030 cites W2060127353 @default.
• W2735097030 cites W2060707997 @default.
• W2735097030 cites W2060863780 @default.
• W2735097030 cites W2067004457 @default.
• W2735097030 cites W2069808171 @default.
• W2735097030 cites W2071715861 @default.
• W2735097030 cites W2073892883 @default.
• W2735097030 cites W2083030627 @default.
• W2735097030 cites W2096376669 @default.
• W2735097030 cites W2103083046 @default.
• W2735097030 cites W2106863904 @default.
• W2735097030 cites W2108751101 @default.
• W2735097030 cites W2111544501 @default.
• W2735097030 cites W2117983072 @default.
• W2735097030 cites W2126371157 @default.
• W2735097030 cites W2126396675 @default.
• W2735097030 cites W2126713416 @default.
• W2735097030 cites W2127685697 @default.
• W2735097030 cites W2130272963 @default.
• W2735097030 cites W2133621994 @default.
• W2735097030 cites W2135781772 @default.
• W2735097030 cites W2136572360 @default.
• W2735097030 cites W2139976079 @default.
• W2735097030 cites W2141462505 @default.
• W2735097030 cites W2143566776 @default.
• W2735097030 cites W2145760956 @default.
• W2735097030 cites W2156627613 @default.
• W2735097030 cites W2161201097 @default.
• W2735097030 cites W2164607984 @default.
• W2735097030 cites W2172126177 @default.
• W2735097030 cites W2230177954 @default.
• W2735097030 cites W2313811921 @default.
• W2735097030 cites W2353246870 @default.
• W2735097030 cites W2397405552 @default.
• W2735097030 cites W2404531077 @default.
• W2735097030 cites W2472332159 @default.
• W2735097030 cites W2480587610 @default.
• W2735097030 cites W2508307990 @default.
• W2735097030 cites W2536660189 @default.
• W2735097030 doi "https://doi.org/10.1038/s41598-017-05844-6" @default.
• W2735097030 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5511146" @default.
• W2735097030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28710457" @default.
• W2735097030 hasPublicationYear "2017" @default.
• W2735097030 type Work @default.

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