FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2735127852> ?p ?o ?g. }

• W2735127852 endingPage "1654" @default.
• W2735127852 startingPage "1642" @default.
• W2735127852 abstract "Hepatocellular carcinoma (HCC) is one of the most refractory cancers. The mechanisms by which hypoxia further aggravates therapeutic responses of advanced HCC to anticancer drugs remain to be clarified. Here, we report that hypoxia (1% O2) caused 2.55–489.7-fold resistance to 6 anticancer drugs (sorafenib, 5-fluorouracil [5-FU], gemcitabine, cisplatin, adriamycin and 6-thioguanine) in 3 HCC cell lines (BEL-7402, HepG2 and SMMC-7721). Among the 6 drugs, sorafenib, the sole one approved for HCC therapy, inhibited proliferation with little influence from hypoxia and displayed the smallest variation among the 3 HCC cell lines tested. By contrast, the inhibition of proliferation by 5-FU, which has been extensively tested in clinical trials but has not been approved for HCC therapy, was severely affected by hypoxia and showed a large variation among these cell lines. In 5-FU-treated HCC cells, hypoxia reduced the levels of basal thymidylate synthase (TS) and functional TS, leading to decreased dTMP synthesis and DNA replication. Hypoxia also affected the accumulation of FdUTP and its misincorporation into DNA. Consequently, both single-strand breaks and double-strand breaks in DNA were reduced, although hypoxia also inhibited DNA repair. In 5-FU-treated HCC cells, hypoxia further abated S-phase arrest, alleviated the loss of mitochondrial membrane potential, diminished the activation of caspases, and finally resulted in reduced induction of apoptosis. Thus, hypoxia induces universal but differential drug resistance. The extensive impacts of hypoxia on the anticancer mechanisms of 5-FU contributes to its hypoxia-induced resistance in HCC cells. We propose that hypoxia-induced drug resistance and interference of hypoxia with anticancer mechanisms could be used as candidate biomarkers in selecting and/or developing anticancer drugs for improving HCC therapy." @default.
• W2735127852 created "2017-07-21" @default.
• W2735127852 creator A5010868615 @default.
• W2735127852 creator A5012208123 @default.
• W2735127852 creator A5013917173 @default.
• W2735127852 creator A5024446633 @default.
• W2735127852 creator A5029849389 @default.
• W2735127852 date "2017-07-10" @default.
• W2735127852 modified "2023-10-04" @default.
• W2735127852 title "Hypoxia induces universal but differential drug resistance and impairs anticancer mechanisms of 5-fluorouracil in hepatoma cells" @default.
• W2735127852 cites W1678674047 @default.
• W2735127852 cites W1834073560 @default.
• W2735127852 cites W1915538437 @default.
• W2735127852 cites W1964423256 @default.
• W2735127852 cites W1965309017 @default.
• W2735127852 cites W1965654886 @default.
• W2735127852 cites W1965929829 @default.
• W2735127852 cites W1971837077 @default.
• W2735127852 cites W1973021910 @default.
• W2735127852 cites W1980683095 @default.
• W2735127852 cites W1981370484 @default.
• W2735127852 cites W1984328540 @default.
• W2735127852 cites W1994193851 @default.
• W2735127852 cites W2017881797 @default.
• W2735127852 cites W2018026948 @default.
• W2735127852 cites W2024398897 @default.
• W2735127852 cites W2032995236 @default.
• W2735127852 cites W2035239663 @default.
• W2735127852 cites W2035747243 @default.
• W2735127852 cites W2036690665 @default.
• W2735127852 cites W2038719984 @default.
• W2735127852 cites W2044387885 @default.
• W2735127852 cites W2056379954 @default.
• W2735127852 cites W2059471266 @default.
• W2735127852 cites W2066571367 @default.
• W2735127852 cites W2074737072 @default.
• W2735127852 cites W2076432328 @default.
• W2735127852 cites W2094170505 @default.
• W2735127852 cites W2098170927 @default.
• W2735127852 cites W2101282905 @default.
• W2735127852 cites W2109359498 @default.
• W2735127852 cites W2133291210 @default.
• W2735127852 cites W2151451173 @default.
• W2735127852 cites W2153935627 @default.
• W2735127852 cites W2154604531 @default.
• W2735127852 cites W2158985124 @default.
• W2735127852 cites W2238432908 @default.
• W2735127852 cites W2259219320 @default.
• W2735127852 cites W2272984102 @default.
• W2735127852 cites W2294765885 @default.
• W2735127852 cites W2318610990 @default.
• W2735127852 cites W2323751645 @default.
• W2735127852 cites W2335992062 @default.
• W2735127852 cites W2340594125 @default.
• W2735127852 cites W2401439946 @default.
• W2735127852 cites W2409960899 @default.
• W2735127852 cites W27905407 @default.
• W2735127852 cites W290932385 @default.
• W2735127852 cites W319948961 @default.
• W2735127852 cites W89030781 @default.
• W2735127852 doi "https://doi.org/10.1038/aps.2017.79" @default.
• W2735127852 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5719160" @default.
• W2735127852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28713155" @default.
• W2735127852 hasPublicationYear "2017" @default.
• W2735127852 type Work @default.
• W2735127852 sameAs 2735127852 @default.
• W2735127852 citedByCount "35" @default.
• W2735127852 countsByYear W27351278522018 @default.
• W2735127852 countsByYear W27351278522019 @default.
• W2735127852 countsByYear W27351278522020 @default.
• W2735127852 countsByYear W27351278522021 @default.
• W2735127852 countsByYear W27351278522022 @default.
• W2735127852 countsByYear W27351278522023 @default.
• W2735127852 crossrefType "journal-article" @default.
• W2735127852 hasAuthorship W2735127852A5010868615 @default.
• W2735127852 hasAuthorship W2735127852A5012208123 @default.
• W2735127852 hasAuthorship W2735127852A5013917173 @default.
• W2735127852 hasAuthorship W2735127852A5024446633 @default.
• W2735127852 hasAuthorship W2735127852A5029849389 @default.
• W2735127852 hasBestOaLocation W27351278521 @default.
• W2735127852 hasConcept C114851261 @default.
• W2735127852 hasConcept C126322002 @default.
• W2735127852 hasConcept C178790620 @default.
• W2735127852 hasConcept C185592680 @default.
• W2735127852 hasConcept C190283241 @default.
• W2735127852 hasConcept C2776694085 @default.
• W2735127852 hasConcept C2778019345 @default.
• W2735127852 hasConcept C2778239845 @default.
• W2735127852 hasConcept C2778695046 @default.
• W2735127852 hasConcept C2779081379 @default.
• W2735127852 hasConcept C2780258809 @default.
• W2735127852 hasConcept C29537977 @default.
• W2735127852 hasConcept C502942594 @default.
• W2735127852 hasConcept C509974204 @default.
• W2735127852 hasConcept C540031477 @default.
• W2735127852 hasConcept C54355233 @default.
• W2735127852 hasConcept C55493867 @default.
• W2735127852 hasConcept C62112901 @default.

• next