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- W2735134347 endingPage "1467" @default.
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- W2735134347 abstract "Atopic dermatitis (AD), psoriasis (PS), and contact dermatitis (CD) are common skin diseases, characterized by barrier disruption and systemic inflammation, with unique epidermal signatures and common inflammatory pathways identified by transcriptomic profiling. This study profiled proteomic signatures in serum from subjects with AD, PS, and CD compared with healthy controls (HC).Identify unique proteomic signatures to distinguish between inflammatory diseases with similar epidermal disruption and overlapping epithelial inflammation.Sera from 20 subjects with moderate to severe AD, 10 subjects with CD, 12 subjects with moderate to severe PS, 10 subjects with both AD and CD, and 10 HC with no history of skin disease was analysed using high-throughput proteomic analysis that detects expression of 1129 protein targets. Protein expression was compared between disease and HC, and across diseases for statistical significance (fold change≥1.5 and false discovery rate≤0.05), to identify unique proteomic signatures for each disease.Complement C5A anaphylatoxin (C5A), lipopolysaccharide binding protein (LBP), C-reactive protein (CRP), ILT-4, C-C motif ligand 18 (PARC), and sialic acid-binding Ig-like lectin 14 (SIG14) were significantly modulated in all three diseases compared with HC. We identified unique signatures for AD (Immunoglobulin E (IgE), thymus- and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC)), CD (10 proteins), and PS (kynureninase (KYNU)). Proteomic profiling in subjects with both AD and CD identified additional dysregulated proteins compared with subjects with either condition alone, indicating an exacerbated inflammation reaction.Unique sera proteomic signatures may distinguish between inflammatory skin diseases despite similar epidermal barrier disruption and epithelial inflammation. This may provide insight into disease pathogenesis, diagnosis, and therapeutic intervention in difficult-to-treat subjects." @default.
- W2735134347 created "2017-07-21" @default.
- W2735134347 creator A5011991547 @default.
- W2735134347 creator A5019704254 @default.
- W2735134347 creator A5024365532 @default.
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- W2735134347 creator A5035849206 @default.
- W2735134347 creator A5040212408 @default.
- W2735134347 creator A5064617600 @default.
- W2735134347 creator A5074081568 @default.
- W2735134347 creator A5080337749 @default.
- W2735134347 date "2017-08-11" @default.
- W2735134347 modified "2023-10-05" @default.
- W2735134347 title "Identification of unique proteomic signatures in allergic and non-allergic skin disease" @default.
- W2735134347 cites W1507201408 @default.
- W2735134347 cites W1512518486 @default.
- W2735134347 cites W1582419036 @default.
- W2735134347 cites W1680121818 @default.
- W2735134347 cites W1828168755 @default.
- W2735134347 cites W1848229364 @default.
- W2735134347 cites W1966930760 @default.
- W2735134347 cites W1975491618 @default.
- W2735134347 cites W1985485597 @default.
- W2735134347 cites W1986991315 @default.
- W2735134347 cites W1988462599 @default.
- W2735134347 cites W1995621118 @default.
- W2735134347 cites W1996181586 @default.
- W2735134347 cites W1999678895 @default.
- W2735134347 cites W2000851235 @default.
- W2735134347 cites W2002600662 @default.
- W2735134347 cites W2003774999 @default.
- W2735134347 cites W2006226706 @default.
- W2735134347 cites W2009792318 @default.
- W2735134347 cites W2011644825 @default.
- W2735134347 cites W2020166689 @default.
- W2735134347 cites W2021018799 @default.
- W2735134347 cites W2022022565 @default.
- W2735134347 cites W2024269336 @default.
- W2735134347 cites W2034284466 @default.
- W2735134347 cites W2040342875 @default.
- W2735134347 cites W2041074604 @default.
- W2735134347 cites W2042118950 @default.
- W2735134347 cites W2044226849 @default.
- W2735134347 cites W2045189254 @default.
- W2735134347 cites W2045778704 @default.
- W2735134347 cites W2047854559 @default.
- W2735134347 cites W2053424469 @default.
- W2735134347 cites W2055018575 @default.
- W2735134347 cites W2057940993 @default.
- W2735134347 cites W2058844396 @default.
- W2735134347 cites W2059688685 @default.
- W2735134347 cites W2060857853 @default.
- W2735134347 cites W2062276423 @default.
- W2735134347 cites W2066356596 @default.
- W2735134347 cites W2067723513 @default.
- W2735134347 cites W2069364241 @default.
- W2735134347 cites W2070835847 @default.
- W2735134347 cites W2074456435 @default.
- W2735134347 cites W2082803782 @default.
- W2735134347 cites W2084373725 @default.
- W2735134347 cites W2087028556 @default.
- W2735134347 cites W2087371579 @default.
- W2735134347 cites W2088251776 @default.
- W2735134347 cites W2090457384 @default.
- W2735134347 cites W2092750645 @default.
- W2735134347 cites W2092868837 @default.
- W2735134347 cites W2094792719 @default.
- W2735134347 cites W2099468529 @default.
- W2735134347 cites W2101583070 @default.
- W2735134347 cites W2103018315 @default.
- W2735134347 cites W2103384599 @default.
- W2735134347 cites W2107390782 @default.
- W2735134347 cites W2108280125 @default.
- W2735134347 cites W2108521730 @default.
- W2735134347 cites W2109689215 @default.
- W2735134347 cites W2110872530 @default.
- W2735134347 cites W2112267975 @default.
- W2735134347 cites W2120086179 @default.
- W2735134347 cites W2120313114 @default.
- W2735134347 cites W2121580723 @default.
- W2735134347 cites W2128218039 @default.
- W2735134347 cites W2132041082 @default.
- W2735134347 cites W2144041275 @default.
- W2735134347 cites W2144444037 @default.
- W2735134347 cites W2145677448 @default.
- W2735134347 cites W2146238632 @default.
- W2735134347 cites W2146302565 @default.
- W2735134347 cites W2146512944 @default.
- W2735134347 cites W2151566115 @default.
- W2735134347 cites W2152407192 @default.
- W2735134347 cites W2153422316 @default.
- W2735134347 cites W2155779547 @default.
- W2735134347 cites W2160129587 @default.
- W2735134347 cites W2164841087 @default.
- W2735134347 cites W2170381128 @default.
- W2735134347 cites W2171578277 @default.
- W2735134347 cites W2198077619 @default.
- W2735134347 cites W2235337704 @default.